3QFH
2.05 Angstrom Resolution Crystal Structure of Epidermin Leader Peptide Processing Serine Protease (EpiP) from Staphylococcus aureus.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004252 | molecular_function | serine-type endopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| A | 0008233 | molecular_function | peptidase activity |
| A | 0008236 | molecular_function | serine-type peptidase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0004252 | molecular_function | serine-type endopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
| B | 0008233 | molecular_function | peptidase activity |
| B | 0008236 | molecular_function | serine-type peptidase activity |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0004252 | molecular_function | serine-type endopeptidase activity |
| C | 0006508 | biological_process | proteolysis |
| C | 0008233 | molecular_function | peptidase activity |
| C | 0008236 | molecular_function | serine-type peptidase activity |
| C | 0016787 | molecular_function | hydrolase activity |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0004252 | molecular_function | serine-type endopeptidase activity |
| D | 0006508 | biological_process | proteolysis |
| D | 0008233 | molecular_function | peptidase activity |
| D | 0008236 | molecular_function | serine-type peptidase activity |
| D | 0016787 | molecular_function | hydrolase activity |
| D | 0046872 | molecular_function | metal ion binding |
| E | 0004252 | molecular_function | serine-type endopeptidase activity |
| E | 0006508 | biological_process | proteolysis |
| E | 0008233 | molecular_function | peptidase activity |
| E | 0008236 | molecular_function | serine-type peptidase activity |
| E | 0016787 | molecular_function | hydrolase activity |
| E | 0046872 | molecular_function | metal ion binding |
| F | 0004252 | molecular_function | serine-type endopeptidase activity |
| F | 0006508 | biological_process | proteolysis |
| F | 0008233 | molecular_function | peptidase activity |
| F | 0008236 | molecular_function | serine-type peptidase activity |
| F | 0016787 | molecular_function | hydrolase activity |
| F | 0046872 | molecular_function | metal ion binding |
| G | 0004252 | molecular_function | serine-type endopeptidase activity |
| G | 0006508 | biological_process | proteolysis |
| G | 0008233 | molecular_function | peptidase activity |
| G | 0008236 | molecular_function | serine-type peptidase activity |
| G | 0016787 | molecular_function | hydrolase activity |
| G | 0046872 | molecular_function | metal ion binding |
| H | 0004252 | molecular_function | serine-type endopeptidase activity |
| H | 0006508 | biological_process | proteolysis |
| H | 0008233 | molecular_function | peptidase activity |
| H | 0008236 | molecular_function | serine-type peptidase activity |
| H | 0016787 | molecular_function | hydrolase activity |
| H | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE NA A 1 |
| Chain | Residue |
| A | LYS409 |
| A | SO4460 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 4 |
| Chain | Residue |
| A | MET343 |
| A | PRO434 |
| A | PHE435 |
| A | SER436 |
| F | ARG385 |
| F | HOH1363 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 5 |
| Chain | Residue |
| A | PRO416 |
| A | ASP417 |
| A | HOH1480 |
| D | LYS38 |
| A | HIS415 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 458 |
| Chain | Residue |
| A | ASN39 |
| A | THR40 |
| A | HIS62 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 459 |
| Chain | Residue |
| A | GLN425 |
| A | HIS440 |
| A | HOH489 |
| F | ARG385 |
| F | HOH477 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 460 |
| Chain | Residue |
| A | NA1 |
| A | LYS130 |
| A | HIS131 |
| A | HIS411 |
| A | HOH1537 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 A 461 |
| Chain | Residue |
| A | LYS219 |
| H | ASN121 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 462 |
| Chain | Residue |
| A | LYS50 |
| A | HIS72 |
| A | ALA75 |
| A | HOH1111 |
| A | HOH1163 |
| B | LYS374 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL B 6 |
| Chain | Residue |
| B | HIS415 |
| B | ASP417 |
| H | LYS38 |
| H | HOH1447 |
| site_id | BC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL B 7 |
| Chain | Residue |
| B | MET343 |
| B | PRO434 |
| B | PHE435 |
| B | SER436 |
| B | HOH1377 |
| E | ARG385 |
| E | HOH1105 |
| site_id | BC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 458 |
| Chain | Residue |
| B | ASN39 |
| B | THR40 |
| B | HIS62 |
| site_id | BC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 B 459 |
| Chain | Residue |
| B | GLN425 |
| B | LYS430 |
| B | HIS440 |
| E | ARG385 |
| E | HOH488 |
| E | HOH489 |
| site_id | BC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 460 |
| Chain | Residue |
| B | LYS130 |
| B | HIS131 |
| B | HIS411 |
| B | HOH924 |
| site_id | BC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 461 |
| Chain | Residue |
| A | LYS374 |
| B | LYS50 |
| B | HIS72 |
| B | ALA75 |
| site_id | BC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 462 |
| Chain | Residue |
| B | LEU335 |
| B | ARG437 |
| B | TYR438 |
| site_id | BC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 463 |
| Chain | Residue |
| B | ASN152 |
| C | LYS49 |
| G | LYS365 |
| site_id | BC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 C 458 |
| Chain | Residue |
| C | ASN39 |
| C | THR40 |
| C | HIS62 |
| C | HOH700 |
| site_id | BC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 C 459 |
| Chain | Residue |
| C | PRO129 |
| C | LYS130 |
| C | HIS131 |
| C | HIS411 |
| site_id | CC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 C 460 |
| Chain | Residue |
| A | LYS414 |
| C | LYS433 |
| C | PRO434 |
| C | ARG437 |
| C | TYR438 |
| site_id | CC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 C 461 |
| Chain | Residue |
| C | ARG385 |
| C | HOH495 |
| C | HOH1488 |
| F | LYS430 |
| site_id | CC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE NA D 2 |
| Chain | Residue |
| D | ASN39 |
| D | ALA41 |
| D | SO4459 |
| site_id | CC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 D 9 |
| Chain | Residue |
| B | ARG385 |
| D | GLN425 |
| D | HIS440 |
| D | HOH485 |
| D | HOH490 |
| site_id | CC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 D 10 |
| Chain | Residue |
| D | GLN331 |
| D | LYS332 |
| D | TYR357 |
| D | LYS374 |
| D | HOH516 |
| D | HOH1230 |
| site_id | CC6 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 D 458 |
| Chain | Residue |
| D | PRO129 |
| D | LYS130 |
| D | HIS131 |
| D | HIS411 |
| D | HOH1342 |
| D | HOH1343 |
| D | HOH1344 |
| G | LYS145 |
| G | ASN146 |
| site_id | CC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 D 459 |
| Chain | Residue |
| D | NA2 |
| D | ASN39 |
| D | THR40 |
| D | HIS62 |
| site_id | CC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL E 8 |
| Chain | Residue |
| B | HIS179 |
| E | PRO129 |
| E | LYS130 |
| E | HIS131 |
| site_id | CC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 E 458 |
| Chain | Residue |
| E | HIS415 |
| E | PRO416 |
| E | ASP417 |
| E | LYS418 |
| site_id | DC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 E 459 |
| Chain | Residue |
| B | LYS151 |
| E | LYS414 |
| E | HIS415 |
| site_id | DC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 E 460 |
| Chain | Residue |
| E | SER429 |
| E | LYS430 |
| E | ASN431 |
| E | LYS447 |
| G | ASN383 |
| G | ARG385 |
| site_id | DC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 E 461 |
| Chain | Residue |
| E | LYS433 |
| E | ARG437 |
| E | TYR438 |
| site_id | DC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 E 462 |
| Chain | Residue |
| E | ASN39 |
| E | THR40 |
| E | HIS62 |
| site_id | DC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 F 458 |
| Chain | Residue |
| F | HIS415 |
| F | PRO416 |
| F | ASP417 |
| F | LYS418 |
| site_id | DC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 F 459 |
| Chain | Residue |
| C | ASN383 |
| C | ARG385 |
| F | THR428 |
| F | SER429 |
| F | LYS430 |
| F | ASN431 |
| F | HOH1364 |
| site_id | DC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 F 460 |
| Chain | Residue |
| F | LYS433 |
| F | ARG437 |
| F | TYR438 |
| site_id | DC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 F 461 |
| Chain | Residue |
| F | ASN39 |
| F | THR40 |
| F | HIS62 |
| H | GLN299 |
| site_id | DC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 G 458 |
| Chain | Residue |
| B | LYS414 |
| G | LYS433 |
| G | PRO434 |
| G | ARG437 |
| G | TYR438 |
| site_id | EC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 G 459 |
| Chain | Residue |
| G | ASN39 |
| G | THR40 |
| G | HIS62 |
| site_id | EC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 G 460 |
| Chain | Residue |
| G | LYS130 |
| G | HIS131 |
| G | HIS411 |
| site_id | EC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 G 461 |
| Chain | Residue |
| G | ARG385 |
| G | HOH489 |
| G | HOH977 |
| site_id | EC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NA H 3 |
| Chain | Residue |
| H | ASN39 |
| H | THR40 |
| H | ALA41 |
| H | SO4461 |
| site_id | EC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 H 458 |
| Chain | Residue |
| A | ARG385 |
| H | GLN425 |
| H | HIS440 |
| H | HOH475 |
| H | HOH482 |
| site_id | EC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 H 459 |
| Chain | Residue |
| H | GLN331 |
| H | LYS332 |
| H | TYR357 |
| H | LYS374 |
| H | HOH467 |
| H | HOH1376 |
| site_id | EC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 H 460 |
| Chain | Residue |
| C | ASN146 |
| H | LYS130 |
| H | HIS131 |
| H | HIS411 |
| H | HOH1372 |
| H | HOH1373 |
| site_id | EC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 H 461 |
| Chain | Residue |
| H | NA3 |
| H | ASN39 |
| H | THR40 |
| H | HIS62 |
| H | HOH1419 |
| site_id | EC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 H 462 |
| Chain | Residue |
| H | LYS50 |
| H | HIS72 |
| H | ALA75 |
| H | HOH1448 |
| H | HOH1516 |
| H | HOH1557 |
| site_id | FC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 H 463 |
| Chain | Residue |
| F | THR40 |
| F | ALA41 |
| F | ASN44 |
| F | HOH1468 |
| H | GLN299 |
| H | LYS302 |
| H | TYR307 |
| H | GLN308 |
| H | GLY309 |
Functional Information from PROSITE/UniProt
| site_id | PS00136 |
| Number of Residues | 12 |
| Details | SUBTILASE_ASP Serine proteases, subtilase family, aspartic acid active site. IAIIDTGVmknH |
| Chain | Residue | Details |
| A | ILE136-HIS147 |
| site_id | PS00138 |
| Number of Residues | 11 |
| Details | SUBTILASE_SER Serine proteases, subtilase family, serine active site. GTSlAtPkVSG |
| Chain | Residue | Details |
| A | GLY391-GLY401 |
