3QCV

Crystal structure of the LT3015 antibody Fab fragment in complex with lysophosphatidic acid (18:2)

Functional Information from GO Data

Chain	GOid	namespace	contents
L	0002250	biological_process	adaptive immune response
L	0003823	molecular_function	antigen binding
L	0005576	cellular_component	extracellular region
L	0005615	cellular_component	extracellular space
L	0005886	cellular_component	plasma membrane
L	0006955	biological_process	immune response
L	0016064	biological_process	immunoglobulin mediated immune response
L	0019814	cellular_component	immunoglobulin complex
L	0050853	biological_process	B cell receptor signaling pathway
L	0070062	cellular_component	extracellular exosome
L	0071735	cellular_component	IgG immunoglobulin complex
L	0071738	cellular_component	IgD immunoglobulin complex
L	0071742	cellular_component	IgE immunoglobulin complex
L	0071745	cellular_component	IgA immunoglobulin complex
L	0071753	cellular_component	IgM immunoglobulin complex
L	0072562	cellular_component	blood microparticle
M	0002250	biological_process	adaptive immune response
M	0003823	molecular_function	antigen binding
M	0005576	cellular_component	extracellular region
M	0005615	cellular_component	extracellular space
M	0005886	cellular_component	plasma membrane
M	0006955	biological_process	immune response
M	0016064	biological_process	immunoglobulin mediated immune response
M	0019814	cellular_component	immunoglobulin complex
M	0050853	biological_process	B cell receptor signaling pathway
M	0070062	cellular_component	extracellular exosome
M	0071735	cellular_component	IgG immunoglobulin complex
M	0071738	cellular_component	IgD immunoglobulin complex
M	0071742	cellular_component	IgE immunoglobulin complex
M	0071745	cellular_component	IgA immunoglobulin complex
M	0071753	cellular_component	IgM immunoglobulin complex
M	0072562	cellular_component	blood microparticle

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	BINDING SITE FOR RESIDUE 18L H 215

Chain	Residue
H	LEU33
H	ASN100
H	TYR100
H	HOH221
I	18L215
L	ASN30
L	TYR32
L	LYS50
L	SER91
H	TYR56
H	PHE96
H	GLY97
H	TYR98
H	TYR99
H	GLY100
H	SER100
H	GLY100

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site_id	AC2
Number of Residues	20
Details	BINDING SITE FOR RESIDUE 18L I 215

Chain	Residue
H	18L215
I	LEU33
I	SER54
I	TYR56
I	PHE96
I	GLY97
I	TYR98
I	TYR99
I	GLY100
I	SER100
I	GLY100
I	ASN100
I	TYR100
I	HOH225
I	HOH240
M	ASN30
M	TYR32
M	LYS50
M	SER91
M	PHE94

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Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH

Chain	Residue	Details
H	TYR194-HIS200
L	TYR192-HIS198

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