3QBE
Crystal structure of the 3-Dehydroquinate Synthase (aroB) from Mycobacterium tuberculosis
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003856 | molecular_function | 3-dehydroquinate synthase activity |
| A | 0005507 | molecular_function | copper ion binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| A | 0009274 | cellular_component | peptidoglycan-based cell wall |
| A | 0009423 | biological_process | chorismate biosynthetic process |
| A | 0016829 | molecular_function | lyase activity |
| A | 0016838 | molecular_function | carbon-oxygen lyase activity, acting on phosphates |
| A | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 400 |
| Chain | Residue |
| A | ASP138 |
| A | GLU186 |
| A | HIS249 |
| A | HIS265 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 401 |
| Chain | Residue |
| A | GLY107 |
| A | THR132 |
| A | LEU134 |
| A | CL500 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL A 500 |
| Chain | Residue |
| A | ZN401 |
| A | GLN45 |
Functional Information from PROSITE/UniProt
| site_id | PS00092 |
| Number of Residues | 7 |
| Details | N6_MTASE N-6 Adenine-specific DNA methylases signature. VAVDPPY |
| Chain | Residue | Details |
| A | VAL12-TYR18 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI2 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00110","evidenceCode":"ECO:0000255"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JAN-2011","submissionDatabase":"PDB data bank","title":"3-dehydroquinate synthase (aroB) from Mycobacterium tuberculosis in complex with NAD.","authors":["Cheng W.C.","Chen T.J.","Wang W.C."]}},{"source":"PDB","id":"3QBD","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"Q6GGU4","evidenceCode":"ECO:0000250"},{"source":"HAMAP-Rule","id":"MF_00110","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00110","evidenceCode":"ECO:0000255"},{"source":"PDB","id":"3QBE","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JAN-2011","submissionDatabase":"PDB data bank","title":"3-dehydroquinate synthase (aroB) from Mycobacterium tuberculosis in complex with NAD.","authors":["Cheng W.C.","Chen T.J.","Wang W.C."]}},{"source":"PDB","id":"3QBD","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
