3QBE

Crystal structure of the 3-Dehydroquinate Synthase (aroB) from Mycobacterium tuberculosis

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003856	molecular_function	3-dehydroquinate synthase activity
A	0005507	molecular_function	copper ion binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0008270	molecular_function	zinc ion binding
A	0008652	biological_process	amino acid biosynthetic process
A	0009073	biological_process	aromatic amino acid family biosynthetic process
A	0009274	cellular_component	peptidoglycan-based cell wall
A	0009423	biological_process	chorismate biosynthetic process
A	0016829	molecular_function	lyase activity
A	0016838	molecular_function	carbon-oxygen lyase activity, acting on phosphates
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 400

Chain	Residue
A	ASP138
A	GLU186
A	HIS249
A	HIS265

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site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 401

Chain	Residue
A	GLY107
A	THR132
A	LEU134
A	CL500

---

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL A 500

Chain	Residue
A	ZN401
A	GLN45

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Functional Information from PROSITE/UniProt

site_id	PS00092
Number of Residues	7
Details	N6_MTASE N-6 Adenine-specific DNA methylases signature. VAVDPPY

Chain	Residue	Details
A	VAL12-TYR18

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|Ref.5, ECO:0007744|PDB:3QBD

Chain	Residue	Details
A	GLN45

---

site_id	SWS_FT_FI2
Number of Residues	5
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00110, ECO:0000269|Ref.5, ECO:0007744|PDB:3QBD

Chain	Residue	Details
A	ASP73
A	GLY107
A	THR131
A	LYS144
A	THR171

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	BINDING: BINDING => ECO:0000250|UniProtKB:Q6GGU4, ECO:0000255|HAMAP-Rule:MF_00110

Chain	Residue	Details
A	LYS153

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site_id	SWS_FT_FI4
Number of Residues	3
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00110, ECO:0007744|PDB:3QBE

Chain	Residue	Details
A	GLU186
A	HIS249
A	HIS265

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