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3QBC

Structure and design of a new pterin site inhibitor of S. aureus HPPK

Functional Information from GO Data
ChainGOidnamespacecontents
A0003848molecular_function2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity
A0009396biological_processfolic acid-containing compound biosynthetic process
A0046654biological_processtetrahydrofolate biosynthetic process
B0003848molecular_function2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity
B0009396biological_processfolic acid-containing compound biosynthetic process
B0046654biological_processtetrahydrofolate biosynthetic process
Functional Information from PDB Data
site_idAC1
Number of Residues9
DetailsBINDING SITE FOR RESIDUE B55 A 159
ChainResidue
ATHR43
AALA44
AVAL46
APHE54
AASN56
APHE123
AHOH268
BPRO109
BLYS110

site_idAC2
Number of Residues10
DetailsBINDING SITE FOR RESIDUE B55 B 163
ChainResidue
APRO109
ALYS110
BTHR43
BALA44
BVAL46
BPHE54
BASN56
BPHE123
BHOH211
BHOH249

Functional Information from PROSITE/UniProt
site_idPS00794
Number of Residues12
DetailsHPPK 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase signature. RwGPRtlDVDIL
ChainResidueDetails
AARG88-LEU99

253389

PDB entries from 2026-05-13

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