3QAU

3-Hydroxy-3-MethylGlutaryl-Coenzyme A Reductase from Streptococcus pneumoniae

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004420	molecular_function	hydroxymethylglutaryl-CoA reductase (NADPH) activity
A	0015936	biological_process	coenzyme A metabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
A	0140643	molecular_function	hydroxymethylglutaryl-CoA reductase (NADH) activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 499

Chain	Residue
A	ARG150
A	GLN178
A	GLU179
A	LYS325
A	HOH744
A	HOH772

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 500

Chain	Residue
A	NA527
A	HOH780
A	ASN212
A	LYS263
A	ASP279

---

site_id	AC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 A 501

Chain	Residue
A	ALA180
A	MET181
A	GLY182
A	ALA183
A	ASN184
A	HOH622
A	HOH623
A	HOH666

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA A 502

Chain	Residue
A	ALA247
A	ALA251
A	ARG257
A	HIS261
A	LEU366

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NA A 503

Chain	Residue
A	ASN69
A	GLY70
A	GLY99
A	PHE101

---

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA A 504

Chain	Residue
A	GLN107
A	THR215
A	ASP216
A	SER217
A	LEU218
A	HOH648

---

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA A 505

Chain	Residue
A	GLN109
A	ILE111
A	ALA214
A	ASP216
A	NA516

---

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA A 506

Chain	Residue
A	SER49
A	GLU50
A	GLU81
A	SER83
A	VAL84
A	VAL85

---

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA A 507

Chain	Residue
A	GLU38
A	GLN39
A	THR55
A	ARG334
A	NA511

---

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA A 508

Chain	Residue
A	ILE283
A	GLY286
A	ALA287
A	PRO319
A	NA529

---

site_id	BC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NA A 509

Chain	Residue
A	GLU80
A	ASN278
A	NA514

---

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NA A 510

Chain	Residue
A	ARG108
A	THR177
A	GLN178
A	HOH633

---

site_id	BC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA A 511

Chain	Residue
A	GLN39
A	MET40
A	SER57
A	ASN332
A	NA507

---

site_id	BC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NA A 512

Chain	Residue
A	LEU58
A	SER328
A	ASN332
A	NA514

---

site_id	BC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA A 513

Chain	Residue
A	HIS261
A	GLY264
A	ASN362
A	ALA365
A	HOH771

---

site_id	BC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA A 514

Chain	Residue
A	PHE56
A	ILE274
A	GLY277
A	NA509
A	NA512

---

site_id	BC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NA A 515

Chain	Residue
A	GLN361
A	ALA365
A	HOH617
A	HOH695

---

site_id	BC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA A 516

Chain	Residue
A	ILE111
A	SER211
A	ALA214
A	NA505
A	HOH621

---

site_id	CC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA A 517

Chain	Residue
A	THR324
A	HIS339
A	ASN344
A	PRO345
A	HOH611

---

site_id	CC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NA A 518

Chain	Residue
A	GLN107
A	SER217
A	VAL219
A	NA530

---

site_id	CC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NA A 519

Chain	Residue
A	PHE266
A	ARG281
A	GLU284
A	HIS288

---

site_id	CC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NA A 520

Chain	Residue
A	SER33
A	GLU38
A	ARG334
A	NA526

---

site_id	CC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA A 521

Chain	Residue
A	GLU29
A	THR102
A	SER222
A	CYS223
A	HOH615

---

site_id	CC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NA A 522

Chain	Residue
A	SER248
A	GLN252
A	SER301

---

site_id	CC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA A 523

Chain	Residue
A	SER49
A	PRO59
A	SER61
A	TYR77
A	THR79

---

site_id	CC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA A 524

Chain	Residue
A	GLU65
A	VAL66
A	LEU67
A	SER92
A	LYS96

---

site_id	CC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE NA A 525

Chain	Residue
A	ARG16
A	ASP46
A	SER49
A	GLU50
A	ASN51
A	VAL52
A	HOH603

---

site_id	DC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NA A 526

Chain	Residue
A	ARG30
A	SER33
A	PRO333
A	NA520

---

site_id	DC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA A 527

Chain	Residue
A	GLU81
A	LYS263
A	ASN267
A	GOL500
A	HOH675

---

site_id	DC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NA A 528

Chain	Residue
A	TYR73
A	THR74
A	LEU341
A	HOH762

---

site_id	DC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA A 529

Chain	Residue
A	ASN212
A	ALA214
A	ALA282
A	PRO321
A	NA508
A	HOH715

---

site_id	DC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NA A 530

Chain	Residue
A	ARG108
A	MET320
A	ALA351
A	NA518

---

site_id	DC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE NA A 531

Chain	Residue
A	THR215
A	ASP216

---

Functional Information from PROSITE/UniProt

site_id	PS01192
Number of Residues	14
Details	HMG_COA_REDUCTASE_3 Hydroxymethylglutaryl-coenzyme A reductases signature 3. ALvStgIqQGHMkL

Chain	Residue	Details
A	ALA368-LEU381

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