3QA2
X-ray Structure of ketohexokinase in complex with a pyrimidopyrimidine analog 2
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004454 | molecular_function | ketohexokinase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006000 | biological_process | fructose metabolic process |
| A | 0016301 | molecular_function | kinase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0032868 | biological_process | response to insulin |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0046835 | biological_process | carbohydrate phosphorylation |
| A | 0070061 | molecular_function | fructose binding |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0070873 | biological_process | regulation of glycogen metabolic process |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004454 | molecular_function | ketohexokinase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006000 | biological_process | fructose metabolic process |
| B | 0016301 | molecular_function | kinase activity |
| B | 0016740 | molecular_function | transferase activity |
| B | 0032868 | biological_process | response to insulin |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0042803 | molecular_function | protein homodimerization activity |
| B | 0046835 | biological_process | carbohydrate phosphorylation |
| B | 0070061 | molecular_function | fructose binding |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0070873 | biological_process | regulation of glycogen metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 301 |
| Chain | Residue |
| A | ARG108 |
| A | THR253 |
| A | GLY255 |
| A | ALA256 |
| A | GLY257 |
| A | ASP258 |
| A | HOH402 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE XNA A 302 |
| Chain | Residue |
| A | PRO246 |
| A | VAL250 |
| A | GLY257 |
| A | PHE260 |
| B | ASP27 |
| A | ALA224 |
| A | ALA226 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 301 |
| Chain | Residue |
| B | ARG78 |
| B | ARG79 |
| B | GLY293 |
| B | PHE294 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 302 |
| Chain | Residue |
| A | ARG31 |
| B | HIS113 |
| B | ARG141 |
| B | LYS174 |
| site_id | AC5 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE XNA B 303 |
| Chain | Residue |
| B | ARG159 |
| B | ALA224 |
| B | ALA226 |
| B | GLU227 |
| B | PHE245 |
| B | PRO246 |
| B | PRO247 |
| B | VAL250 |
| B | ALA256 |
| B | GLY257 |
| B | PHE260 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"19237742","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2HW1","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PDB","id":"2HW1","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"19237742","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2HW1","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
