3Q8V

Crystal structure of Staphylococcus aureus nucleoside diphosphate kinase complexed with UDP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004550	molecular_function	nucleoside diphosphate kinase activity
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0006183	biological_process	GTP biosynthetic process
A	0006228	biological_process	UTP biosynthetic process
A	0006241	biological_process	CTP biosynthetic process
B	0004550	molecular_function	nucleoside diphosphate kinase activity
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0006183	biological_process	GTP biosynthetic process
B	0006228	biological_process	UTP biosynthetic process
B	0006241	biological_process	CTP biosynthetic process
C	0004550	molecular_function	nucleoside diphosphate kinase activity
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0006183	biological_process	GTP biosynthetic process
C	0006228	biological_process	UTP biosynthetic process
C	0006241	biological_process	CTP biosynthetic process
D	0004550	molecular_function	nucleoside diphosphate kinase activity
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0006183	biological_process	GTP biosynthetic process
D	0006228	biological_process	UTP biosynthetic process
D	0006241	biological_process	CTP biosynthetic process
E	0004550	molecular_function	nucleoside diphosphate kinase activity
E	0005524	molecular_function	ATP binding
E	0005737	cellular_component	cytoplasm
E	0006183	biological_process	GTP biosynthetic process
E	0006228	biological_process	UTP biosynthetic process
E	0006241	biological_process	CTP biosynthetic process
F	0004550	molecular_function	nucleoside diphosphate kinase activity
F	0005524	molecular_function	ATP binding
F	0005737	cellular_component	cytoplasm
F	0006183	biological_process	GTP biosynthetic process
F	0006228	biological_process	UTP biosynthetic process
F	0006241	biological_process	CTP biosynthetic process
G	0004550	molecular_function	nucleoside diphosphate kinase activity
G	0005524	molecular_function	ATP binding
G	0005737	cellular_component	cytoplasm
G	0006183	biological_process	GTP biosynthetic process
G	0006228	biological_process	UTP biosynthetic process
G	0006241	biological_process	CTP biosynthetic process
H	0004550	molecular_function	nucleoside diphosphate kinase activity
H	0005524	molecular_function	ATP binding
H	0005737	cellular_component	cytoplasm
H	0006183	biological_process	GTP biosynthetic process
H	0006228	biological_process	UTP biosynthetic process
H	0006241	biological_process	CTP biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE UDP A 158

Chain	Residue
A	LYS9
A	MG159
A	HOH182
A	HOH206
A	HIS52
A	PHE57
A	LEU61
A	THR91
A	ARG102
A	VAL109
A	GLY110
A	ASN112

---

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG A 159

Chain	Residue
A	THR91
A	ARG102
A	UDP158

---

site_id	AC3
Number of Residues	12
Details	BINDING SITE FOR RESIDUE UDP B 158

Chain	Residue
B	LYS9
B	HIS52
B	PHE57
B	THR91
B	ARG102
B	VAL109
B	GLY110
B	ASN112
B	MG159
B	HOH178
B	HOH179
B	HOH200

---

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG B 159

Chain	Residue
B	UDP158
B	HOH179
B	HOH198

---

site_id	AC5
Number of Residues	13
Details	BINDING SITE FOR RESIDUE UDP D 158

Chain	Residue
D	LYS9
D	HIS52
D	PHE57
D	THR91
D	ARG102
D	VAL109
D	GLY110
D	ASN112
D	MG159
D	HOH183
D	HOH207
D	HOH208
D	HOH209

---

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG D 159

Chain	Residue
D	UDP158
D	HOH208
D	HOH209

---

Functional Information from PROSITE/UniProt

site_id	PS00469
Number of Residues	9
Details	NDPK Nucleoside diphosphate kinase (NDPK) active site signature. NiiHGSDSL

Chain	Residue	Details
A	ASN112-LEU120

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Active site: {"description":"Pros-phosphohistidine intermediate","evidences":[{"source":"HAMAP-Rule","id":"MF_00451","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	48
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00451","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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