3Q7H
Structure of the ClpP subunit of the ATP-dependent Clp Protease from Coxiella burnetii
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004176 | molecular_function | ATP-dependent peptidase activity |
| A | 0004252 | molecular_function | serine-type endopeptidase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006508 | biological_process | proteolysis |
| A | 0006515 | biological_process | protein quality control for misfolded or incompletely synthesized proteins |
| A | 0008236 | molecular_function | serine-type peptidase activity |
| A | 0009368 | cellular_component | endopeptidase Clp complex |
| A | 0051117 | molecular_function | ATPase binding |
| B | 0004176 | molecular_function | ATP-dependent peptidase activity |
| B | 0004252 | molecular_function | serine-type endopeptidase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006508 | biological_process | proteolysis |
| B | 0006515 | biological_process | protein quality control for misfolded or incompletely synthesized proteins |
| B | 0008236 | molecular_function | serine-type peptidase activity |
| B | 0009368 | cellular_component | endopeptidase Clp complex |
| B | 0051117 | molecular_function | ATPase binding |
| C | 0004176 | molecular_function | ATP-dependent peptidase activity |
| C | 0004252 | molecular_function | serine-type endopeptidase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006508 | biological_process | proteolysis |
| C | 0006515 | biological_process | protein quality control for misfolded or incompletely synthesized proteins |
| C | 0008236 | molecular_function | serine-type peptidase activity |
| C | 0009368 | cellular_component | endopeptidase Clp complex |
| C | 0051117 | molecular_function | ATPase binding |
| D | 0004176 | molecular_function | ATP-dependent peptidase activity |
| D | 0004252 | molecular_function | serine-type endopeptidase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0006508 | biological_process | proteolysis |
| D | 0006515 | biological_process | protein quality control for misfolded or incompletely synthesized proteins |
| D | 0008236 | molecular_function | serine-type peptidase activity |
| D | 0009368 | cellular_component | endopeptidase Clp complex |
| D | 0051117 | molecular_function | ATPase binding |
| E | 0004176 | molecular_function | ATP-dependent peptidase activity |
| E | 0004252 | molecular_function | serine-type endopeptidase activity |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0006508 | biological_process | proteolysis |
| E | 0006515 | biological_process | protein quality control for misfolded or incompletely synthesized proteins |
| E | 0008236 | molecular_function | serine-type peptidase activity |
| E | 0009368 | cellular_component | endopeptidase Clp complex |
| E | 0051117 | molecular_function | ATPase binding |
| F | 0004176 | molecular_function | ATP-dependent peptidase activity |
| F | 0004252 | molecular_function | serine-type endopeptidase activity |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0006508 | biological_process | proteolysis |
| F | 0006515 | biological_process | protein quality control for misfolded or incompletely synthesized proteins |
| F | 0008236 | molecular_function | serine-type peptidase activity |
| F | 0009368 | cellular_component | endopeptidase Clp complex |
| F | 0051117 | molecular_function | ATPase binding |
| G | 0004176 | molecular_function | ATP-dependent peptidase activity |
| G | 0004252 | molecular_function | serine-type endopeptidase activity |
| G | 0005737 | cellular_component | cytoplasm |
| G | 0006508 | biological_process | proteolysis |
| G | 0006515 | biological_process | protein quality control for misfolded or incompletely synthesized proteins |
| G | 0008236 | molecular_function | serine-type peptidase activity |
| G | 0009368 | cellular_component | endopeptidase Clp complex |
| G | 0051117 | molecular_function | ATPase binding |
| H | 0004176 | molecular_function | ATP-dependent peptidase activity |
| H | 0004252 | molecular_function | serine-type endopeptidase activity |
| H | 0005737 | cellular_component | cytoplasm |
| H | 0006508 | biological_process | proteolysis |
| H | 0006515 | biological_process | protein quality control for misfolded or incompletely synthesized proteins |
| H | 0008236 | molecular_function | serine-type peptidase activity |
| H | 0009368 | cellular_component | endopeptidase Clp complex |
| H | 0051117 | molecular_function | ATPase binding |
| I | 0004176 | molecular_function | ATP-dependent peptidase activity |
| I | 0004252 | molecular_function | serine-type endopeptidase activity |
| I | 0005737 | cellular_component | cytoplasm |
| I | 0006508 | biological_process | proteolysis |
| I | 0006515 | biological_process | protein quality control for misfolded or incompletely synthesized proteins |
| I | 0008236 | molecular_function | serine-type peptidase activity |
| I | 0009368 | cellular_component | endopeptidase Clp complex |
| I | 0051117 | molecular_function | ATPase binding |
| J | 0004176 | molecular_function | ATP-dependent peptidase activity |
| J | 0004252 | molecular_function | serine-type endopeptidase activity |
| J | 0005737 | cellular_component | cytoplasm |
| J | 0006508 | biological_process | proteolysis |
| J | 0006515 | biological_process | protein quality control for misfolded or incompletely synthesized proteins |
| J | 0008236 | molecular_function | serine-type peptidase activity |
| J | 0009368 | cellular_component | endopeptidase Clp complex |
| J | 0051117 | molecular_function | ATPase binding |
| K | 0004176 | molecular_function | ATP-dependent peptidase activity |
| K | 0004252 | molecular_function | serine-type endopeptidase activity |
| K | 0005737 | cellular_component | cytoplasm |
| K | 0006508 | biological_process | proteolysis |
| K | 0006515 | biological_process | protein quality control for misfolded or incompletely synthesized proteins |
| K | 0008236 | molecular_function | serine-type peptidase activity |
| K | 0009368 | cellular_component | endopeptidase Clp complex |
| K | 0051117 | molecular_function | ATPase binding |
| L | 0004176 | molecular_function | ATP-dependent peptidase activity |
| L | 0004252 | molecular_function | serine-type endopeptidase activity |
| L | 0005737 | cellular_component | cytoplasm |
| L | 0006508 | biological_process | proteolysis |
| L | 0006515 | biological_process | protein quality control for misfolded or incompletely synthesized proteins |
| L | 0008236 | molecular_function | serine-type peptidase activity |
| L | 0009368 | cellular_component | endopeptidase Clp complex |
| L | 0051117 | molecular_function | ATPase binding |
| M | 0004176 | molecular_function | ATP-dependent peptidase activity |
| M | 0004252 | molecular_function | serine-type endopeptidase activity |
| M | 0005737 | cellular_component | cytoplasm |
| M | 0006508 | biological_process | proteolysis |
| M | 0006515 | biological_process | protein quality control for misfolded or incompletely synthesized proteins |
| M | 0008236 | molecular_function | serine-type peptidase activity |
| M | 0009368 | cellular_component | endopeptidase Clp complex |
| M | 0051117 | molecular_function | ATPase binding |
| N | 0004176 | molecular_function | ATP-dependent peptidase activity |
| N | 0004252 | molecular_function | serine-type endopeptidase activity |
| N | 0005737 | cellular_component | cytoplasm |
| N | 0006508 | biological_process | proteolysis |
| N | 0006515 | biological_process | protein quality control for misfolded or incompletely synthesized proteins |
| N | 0008236 | molecular_function | serine-type peptidase activity |
| N | 0009368 | cellular_component | endopeptidase Clp complex |
| N | 0051117 | molecular_function | ATPase binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PEG A 196 |
| Chain | Residue |
| A | HIS158 |
| A | THR159 |
| A | PEG198 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE PEG A 197 |
| Chain | Residue |
| B | TYR130 |
| B | ILE137 |
| B | HIS140 |
| B | ALA141 |
| A | TYR130 |
| A | ILE137 |
| A | HIS140 |
| A | ALA141 |
| A | THR144 |
| A | HOH206 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PEG A 198 |
| Chain | Residue |
| A | THR159 |
| A | LYS161 |
| A | VAL182 |
| A | GLU183 |
| A | TYR184 |
| A | PEG196 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA A 199 |
| Chain | Residue |
| A | MSE82 |
| A | VAL85 |
| A | PRO87 |
| A | HOH409 |
| A | HOH664 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PEG B 196 |
| Chain | Residue |
| B | TYR64 |
| B | ARG90 |
| B | PHE191 |
| B | ARG194 |
| B | HOH878 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PEG B 197 |
| Chain | Residue |
| B | HIS158 |
| B | THR159 |
| B | GLY160 |
| B | PEG198 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PEG B 198 |
| Chain | Residue |
| B | THR159 |
| B | LYS161 |
| B | GLU183 |
| B | GLY185 |
| B | PEG197 |
| B | HOH1061 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA B 199 |
| Chain | Residue |
| B | MSE82 |
| B | VAL85 |
| B | PRO87 |
| B | HOH1142 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CA B 200 |
| Chain | Residue |
| B | VAL72 |
| B | LEU127 |
| site_id | BC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE PEG C 196 |
| Chain | Residue |
| C | HIS158 |
| C | THR159 |
| site_id | BC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PEG C 197 |
| Chain | Residue |
| A | PRO117 |
| A | LYS192 |
| C | TYR79 |
| C | ASP80 |
| C | GLN83 |
| C | PHE84 |
| C | HOH895 |
| site_id | BC3 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE PEG C 198 |
| Chain | Residue |
| C | PRO68 |
| C | GLY69 |
| C | GLY70 |
| C | ALA98 |
| C | SER99 |
| C | ALA100 |
| C | MSE122 |
| C | HIS124 |
| C | HOH212 |
| C | HOH924 |
| C | HOH1090 |
| site_id | BC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA C 199 |
| Chain | Residue |
| C | MSE82 |
| C | VAL85 |
| C | PRO87 |
| C | HOH585 |
| C | HOH1350 |
| site_id | BC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CA C 200 |
| Chain | Residue |
| C | VAL72 |
| C | LEU127 |
| site_id | BC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE PEG D 196 |
| Chain | Residue |
| D | ASN62 |
| D | ARG90 |
| site_id | BC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA D 197 |
| Chain | Residue |
| D | MSE82 |
| D | VAL85 |
| D | PRO87 |
| D | HOH486 |
| D | HOH560 |
| site_id | BC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CA D 198 |
| Chain | Residue |
| D | VAL72 |
| D | LEU127 |
| site_id | BC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PEG E 196 |
| Chain | Residue |
| E | TYR130 |
| E | GLN131 |
| F | TYR130 |
| F | GLN131 |
| site_id | CC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA E 197 |
| Chain | Residue |
| E | MSE82 |
| E | VAL85 |
| E | PRO87 |
| E | HOH200 |
| E | HOH597 |
| site_id | CC2 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CA E 198 |
| Chain | Residue |
| E | GLU183 |
| site_id | CC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CA E 199 |
| Chain | Residue |
| E | VAL72 |
| E | LEU127 |
| site_id | CC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE PEG F 196 |
| Chain | Residue |
| F | HIS158 |
| F | THR159 |
| site_id | CC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CA F 197 |
| Chain | Residue |
| F | MSE82 |
| F | VAL85 |
| F | PRO87 |
| site_id | CC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CA F 198 |
| Chain | Residue |
| F | LEU127 |
| F | VAL72 |
| site_id | CC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PEG G 196 |
| Chain | Residue |
| G | LYS192 |
| G | GLU193 |
| G | ARG194 |
| G | HOH1217 |
| I | GLN83 |
| site_id | CC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PEG G 197 |
| Chain | Residue |
| G | GLN36 |
| G | VAL37 |
| G | GLU38 |
| G | GLY70 |
| G | ALA71 |
| G | HOH745 |
| site_id | CC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA G 198 |
| Chain | Residue |
| G | MSE82 |
| G | VAL85 |
| G | PRO87 |
| G | HOH205 |
| site_id | DC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CA G 199 |
| Chain | Residue |
| G | VAL72 |
| G | LEU127 |
| site_id | DC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PEG H 196 |
| Chain | Residue |
| H | ASN62 |
| H | TYR64 |
| H | PHE191 |
| H | ARG194 |
| H | HOH758 |
| H | HOH1119 |
| site_id | DC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE PEG H 197 |
| Chain | Residue |
| H | HIS158 |
| H | THR159 |
| site_id | DC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PEG H 198 |
| Chain | Residue |
| H | ILE139 |
| H | LYS142 |
| H | GLN143 |
| H | HOH241 |
| J | PHE175 |
| J | HOH736 |
| site_id | DC5 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE PEG H 199 |
| Chain | Residue |
| G | TYR130 |
| G | ILE137 |
| G | ALA141 |
| H | TYR130 |
| H | ILE137 |
| H | HIS140 |
| H | ALA141 |
| H | THR144 |
| H | HOH552 |
| site_id | DC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA H 200 |
| Chain | Residue |
| H | MSE82 |
| H | VAL85 |
| H | PRO87 |
| H | HOH667 |
| site_id | DC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CA H 201 |
| Chain | Residue |
| H | VAL72 |
| H | LEU127 |
| site_id | DC8 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE PEG I 196 |
| Chain | Residue |
| G | HIS118 |
| G | SER119 |
| G | SER120 |
| G | LEU176 |
| G | THR177 |
| I | GLN143 |
| I | ARG146 |
| I | GLN150 |
| I | HOH473 |
| site_id | DC9 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE PEG I 197 |
| Chain | Residue |
| I | TYR130 |
| I | ILE137 |
| I | HIS140 |
| I | ALA141 |
| I | THR144 |
| J | TYR130 |
| J | ILE137 |
| J | HIS140 |
| J | ALA141 |
| J | HOH438 |
| site_id | EC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PEG I 198 |
| Chain | Residue |
| I | LYS161 |
| I | GLU180 |
| I | GLU183 |
| I | TYR184 |
| site_id | EC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PEG I 199 |
| Chain | Residue |
| I | THR159 |
| I | LYS161 |
| I | GLU183 |
| I | TYR184 |
| site_id | EC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA I 200 |
| Chain | Residue |
| I | MSE82 |
| I | VAL85 |
| I | PRO87 |
| I | HOH210 |
| site_id | EC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CA I 201 |
| Chain | Residue |
| I | VAL72 |
| I | LEU127 |
| site_id | EC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PEG J 196 |
| Chain | Residue |
| I | GLN138 |
| J | GLN138 |
| J | ALA141 |
| J | LYS142 |
| J | GLN145 |
| site_id | EC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE PEG J 197 |
| Chain | Residue |
| J | LYS157 |
| J | HIS158 |
| site_id | EC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PEG J 198 |
| Chain | Residue |
| I | TYR130 |
| I | GLN131 |
| I | HOH966 |
| J | TYR130 |
| J | GLN131 |
| site_id | EC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA J 199 |
| Chain | Residue |
| J | MSE82 |
| J | VAL85 |
| J | PRO87 |
| J | HOH660 |
| J | HOH951 |
| site_id | EC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CA J 200 |
| Chain | Residue |
| J | VAL72 |
| J | LEU127 |
| site_id | FC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PEG K 196 |
| Chain | Residue |
| K | TYR130 |
| K | GLN131 |
| L | TYR130 |
| L | GLN131 |
| site_id | FC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PEG K 197 |
| Chain | Residue |
| K | HIS158 |
| K | THR159 |
| K | GLY160 |
| site_id | FC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA K 198 |
| Chain | Residue |
| K | MSE82 |
| K | VAL85 |
| K | PRO87 |
| K | HOH206 |
| site_id | FC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CA K 199 |
| Chain | Residue |
| K | VAL72 |
| K | LEU127 |
| site_id | FC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE PEG L 196 |
| Chain | Residue |
| L | LYS59 |
| L | HOH267 |
| site_id | FC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PEG L 197 |
| Chain | Residue |
| L | HIS158 |
| L | THR159 |
| L | HOH1108 |
| site_id | FC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA L 198 |
| Chain | Residue |
| L | MSE82 |
| L | VAL85 |
| L | PRO87 |
| L | HOH525 |
| L | HOH605 |
| site_id | FC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CA L 199 |
| Chain | Residue |
| L | VAL72 |
| L | LEU127 |
| site_id | FC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PEG M 196 |
| Chain | Residue |
| M | LYS157 |
| M | THR159 |
| M | HOH314 |
| site_id | GC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE PEG M 197 |
| Chain | Residue |
| M | ASN58 |
| M | HOH1009 |
| site_id | GC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA M 198 |
| Chain | Residue |
| M | MSE82 |
| M | VAL85 |
| M | PRO87 |
| M | HOH588 |
| M | HOH689 |
| M | HOH769 |
| site_id | GC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CA M 199 |
| Chain | Residue |
| M | VAL72 |
| M | VAL126 |
| M | LEU127 |
| site_id | GC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PEG N 196 |
| Chain | Residue |
| N | HIS158 |
| N | THR159 |
| N | GLY160 |
| site_id | GC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PEG N 197 |
| Chain | Residue |
| B | TYR22 |
| B | VAL34 |
| B | GLY35 |
| N | ASP39 |
| N | HIS40 |
| N | ASN43 |
| N | LEU44 |
| N | HOH724 |
| site_id | GC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CA N 198 |
| Chain | Residue |
| N | MSE82 |
| N | VAL85 |
| N | PRO87 |
| site_id | GC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CA N 199 |
| Chain | Residue |
| N | VAL72 |
| N | LEU127 |
Functional Information from PROSITE/UniProt
| site_id | PS00381 |
| Number of Residues | 12 |
| Details | CLP_PROTEASE_SER Endopeptidase Clp serine active site. TlcIGqAASAGA |
| Chain | Residue | Details |
| A | THR91-ALA102 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 14 |
| Details | ACT_SITE: Nucleophile => ECO:0000255|HAMAP-Rule:MF_00444 |
| Chain | Residue | Details |
| A | SER99 | |
| J | SER99 | |
| K | SER99 | |
| L | SER99 | |
| M | SER99 | |
| N | SER99 | |
| B | SER99 | |
| C | SER99 | |
| D | SER99 | |
| E | SER99 | |
| F | SER99 | |
| G | SER99 | |
| H | SER99 | |
| I | SER99 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 14 |
| Details | ACT_SITE: ACT_SITE => ECO:0000255|HAMAP-Rule:MF_00444 |
| Chain | Residue | Details |
| A | HIS124 | |
| J | HIS124 | |
| K | HIS124 | |
| L | HIS124 | |
| M | HIS124 | |
| N | HIS124 | |
| B | HIS124 | |
| C | HIS124 | |
| D | HIS124 | |
| E | HIS124 | |
| F | HIS124 | |
| G | HIS124 | |
| H | HIS124 | |
| I | HIS124 |
