Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0004675 | molecular_function | transmembrane receptor protein serine/threonine kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006468 | biological_process | protein phosphorylation |
| A | 0007178 | biological_process | cell surface receptor protein serine/threonine kinase signaling pathway |
| A | 0016020 | cellular_component | membrane |
| B | 0004672 | molecular_function | protein kinase activity |
| B | 0004675 | molecular_function | transmembrane receptor protein serine/threonine kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006468 | biological_process | protein phosphorylation |
| B | 0007178 | biological_process | cell surface receptor protein serine/threonine kinase signaling pathway |
| B | 0016020 | cellular_component | membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE TAK B 1 |
| Chain | Residue |
| A | HOH660 |
| B | GLY273 |
| B | ASP277 |
| B | LEU329 |
| B | LYS198 |
| B | ALA217 |
| B | LYS219 |
| B | LEU247 |
| B | THR267 |
| B | ALA268 |
| B | PHE269 |
| B | HIS270 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE TAK A 2 |
| Chain | Residue |
| A | ALA217 |
| A | LYS219 |
| A | LEU247 |
| A | THR267 |
| A | ALA268 |
| A | PHE269 |
| A | HIS270 |
| A | GLU271 |
| A | GLY273 |
| A | LEU329 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 B 489 |
| Chain | Residue |
| B | HOH59 |
| B | HOH159 |
| B | HIS270 |
| B | LYS331 |
| B | ASN332 |
| B | HOH515 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 3 |
| Chain | Residue |
| A | HOH109 |
| A | HOH131 |
| A | HOH147 |
| A | HIS270 |
| A | LYS331 |
| A | ASN332 |
| A | HOH499 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 4 |
| Chain | Residue |
| A | HOH132 |
| A | HOH144 |
| A | ARG202 |
| A | THR362 |
| A | ARG363 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 5 |
| Chain | Residue |
| B | ARG442 |
| B | ASP443 |
| B | TYR444 |
| site_id | AC7 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE EDO B 490 |
| Chain | Residue |
| B | ASN231 |
| B | GLU234 |
| B | VAL235 |
| B | ALA344 |
| B | LEU345 |
| B | LYS346 |
| B | HOH618 |
| B | HOH619 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO B 2 |
| Chain | Residue |
| B | HOH112 |
| B | ARG438 |
| B | ASP463 |
| B | HIS464 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO A 489 |
| Chain | Residue |
| A | ASN231 |
| A | GLU234 |
| A | ALA344 |
| A | LEU345 |
| A | LYS346 |
| A | HOH530 |
| A | HOH558 |
| site_id | BC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE EDO A 490 |
| Chain | Residue |
| A | EDO19 |
| A | HOH155 |
| A | GLU244 |
| A | ARG298 |
| A | HOH622 |
| B | LYS198 |
| B | ALA199 |
| B | ARG200 |
| B | HOH635 |
| site_id | BC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 5 |
| Chain | Residue |
| A | PHE-3 |
| A | GLN-2 |
| A | SER-1 |
| A | TYR-4 |
| A | GLU253 |
| B | HOH160 |
| site_id | BC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO B 6 |
| Chain | Residue |
| A | ASN332 |
| B | TYR411 |
| B | GLU416 |
| B | HOH611 |
| site_id | BC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 7 |
| Chain | Residue |
| A | LYS436 |
| A | ASP463 |
| A | HIS464 |
| A | HOH577 |
| site_id | BC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 8 |
| Chain | Residue |
| A | ASN-6 |
| A | PRO191 |
| A | GLN193 |
| A | GLN210 |
| A | LEU212 |
| site_id | BC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO B 9 |
| Chain | Residue |
| B | GLN-2 |
| B | GLN-2 |
| B | HOH89 |
| B | HOH613 |
| B | HOH637 |
| site_id | BC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO B 11 |
| Chain | Residue |
| B | LYS326 |
| B | HOH517 |
| B | ARG200 |
| B | GLY201 |
| B | ARG202 |
| B | LYS324 |
| site_id | BC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 12 |
| Chain | Residue |
| A | ASP306 |
| A | HIS314 |
| A | GLU348 |
| A | ALA349 |
| site_id | BC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO B 13 |
| Chain | Residue |
| B | ASN-6 |
| B | TYR-4 |
| B | LYS226 |
| B | LYS254 |
| site_id | CC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO A 14 |
| Chain | Residue |
| A | GLU430 |
| A | HIS434 |
| A | HOH630 |
| site_id | CC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO B 15 |
| Chain | Residue |
| B | EDO20 |
| B | THR362 |
| B | ARG364 |
| B | GLN421 |
| B | HOH547 |
| site_id | CC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO A 17 |
| Chain | Residue |
| A | GLN210 |
| A | ASN213 |
| A | TYR215 |
| site_id | CC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 18 |
| Chain | Residue |
| A | LYS324 |
| A | LYS326 |
| A | THR362 |
| A | ARG364 |
| A | HOH517 |
| site_id | CC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE EDO A 19 |
| Chain | Residue |
| A | HOH155 |
| A | HIS291 |
| A | ASN333 |
| A | THR335 |
| A | EDO490 |
| A | HOH587 |
| B | ARG200 |
| B | LYS326 |
| site_id | CC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO B 20 |
| Chain | Residue |
| B | EDO15 |
| B | LYS324 |
| B | LYS326 |
| B | HOH547 |
| site_id | CC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO B 21 |
| Chain | Residue |
| A | ASN287 |
| B | ARG363 |
| B | LEU425 |
| B | HOH536 |
| site_id | CC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO B 22 |
| Chain | Residue |
| B | ARG255 |
| B | GLY256 |
| B | HOH528 |
| B | HOH528 |
| B | HOH600 |
| site_id | CC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO B 23 |
| Chain | Residue |
| A | SER424 |
| B | HOH181 |
| B | TRP286 |
| B | HIS448 |
| B | HOH563 |
| site_id | DC1 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE PG4 A 16 |
| Chain | Residue |
| A | THR-8 |
| A | SER-1 |
| A | ASN-6 |
| A | TYR-4 |
| A | HOH142 |
| A | HOH568 |
| B | HOH45 |
| B | ALA281 |
| B | ASN282 |
| B | VAL283 |
| B | ARG400 |
| B | GLU410 |
Functional Information from PROSITE/UniProt
| site_id | PS00108 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IsHrDIKskNVLL |
| Chain | Residue | Details |
| A | ILE318-LEU330 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 18 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]} |
