3Q3G

Crystal Structure of A-domain in complex with antibody

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CA G 500

Chain	Residue
D	ASP107
G	SER142
G	SER144
G	THR209
G	ASP242
G	HOH1008
G	HOH1009

---

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CA E 500

Chain	Residue
E	SER142
E	SER144
E	THR209
E	ASP242
E	HOH1009
A	HOH1008
B	ASP107

---

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CA I 500

Chain	Residue
F	HOH1008
H	ASP107
I	SER142
I	SER144
I	THR209
I	ASP242
I	HOH1009

---

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CA L 500

Chain	Residue
J	HOH1008
K	ASP107
L	SER142
L	SER144
L	THR209
L	ASP242
L	HOH1009

---

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO G 620

Chain	Residue
C	SER33
G	ASP242
G	HOH1008

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL G 703

Chain	Residue
D	LYS59
G	PHE180
G	ILE182
G	LYS217
G	GLU221

---

site_id	AC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL G 907

Chain	Residue
G	ASP260
G	VAL264

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO E 600

Chain	Residue
A	TYR100
B	LYS61
E	HIS210
E	GLY247

---

site_id	AC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO E 627

Chain	Residue
D	TYR104
E	ARG152

---

site_id	BC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL E 902

Chain	Residue
E	ASP260
E	VAL264
E	SER289

---

site_id	BC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL E 906

Chain	Residue
E	PHE180
E	GLU221

---

site_id	BC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO F 621

Chain	Residue
F	HOH1008
I	ASP242

---

site_id	BC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO L 610

Chain	Residue
A	ARG194
J	SER32
L	ASP273
L	ALA274
L	PHE275
L	ARG276
L	SER277

---

site_id	BC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO L 615

Chain	Residue
L	VAL219
L	ARG220
L	PHE223
L	ASN224
L	LYS235
L	GLU262
L	HOH1098

---

site_id	BC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO C 609

Chain	Residue
C	PHE104
C	HOH1242
D	LEU47

---

site_id	BC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO C 628

Chain	Residue
C	ASN144
C	ASP173
D	GLY173
D	VAL174
D	HIS175

---

site_id	BC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL C 710

Chain	Residue
C	GLU61
D	TYR104
D	TYR109
D	ASP112
E	GLU155

---

site_id	BC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 618

Chain	Residue
A	GLN44
A	LYS45
A	GLY47
A	GLN48

---

site_id	CC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 625

Chain	Residue
A	LYS36
A	ASN37
A	TRP56
A	SER58
A	HOH1236

---

site_id	CC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL A 700

Chain	Residue
A	ASP1
A	GLU3
J	SER14

---

site_id	CC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO D 604

Chain	Residue
D	THR60
D	LYS61
D	TYR62

---

site_id	CC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO D 605

Chain	Residue
D	SER189
C	SER168
C	SER182
C	THR184
D	PRO178
D	THR187
D	LEU188

---

site_id	CC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO D 613

Chain	Residue
D	SER23
D	THR25

---

site_id	CC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO D 614

Chain	Residue
D	ASP75
D	THR76
D	SER77
D	GOL702
H	ASN166
H	SER169
H	THR203

---

site_id	CC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO D 619

Chain	Residue
B	PRO129
C	GLU129
D	VAL132
D	LYS219
D	GOL708

---

site_id	CC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL D 702

Chain	Residue
D	ASP58
D	ALA74
D	ASP75
D	EDO614
D	HOH1232
H	GLU202

---

site_id	CC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL D 705

Chain	Residue
D	LYS40
D	GLU48
D	GLU91
D	ASP92

---

site_id	DC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL D 708

Chain	Residue
B	PRO130
B	VAL132
B	LYS219
D	PRO130
D	THR215
D	EDO619

---

site_id	DC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE NA D 800

Chain	Residue
D	THR119

---

site_id	DC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE NA H 801

Chain	Residue
H	VAL132

---

site_id	DC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE NA H 802

Chain	Residue
H	LYS40

---

site_id	DC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PEG H 1000

Chain	Residue
H	PHE29
H	ILE34
H	SER100
H	GLY102
H	TYR104
H	ASP112
H	TYR113

---

site_id	DC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO J 603

Chain	Residue
H	ALA212
H	SER213
J	SER128
J	GLU129

---

site_id	DC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO J 622

Chain	Residue
J	ASP1
J	GLN27
J	SER99

---

site_id	DC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL J 709

Chain	Residue
J	SER9
J	VAL91
J	TYR93
J	ALA106
J	GLY107
J	LYS109
K	GLN45

---

site_id	DC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL J 903

Chain	Residue
J	SER182
J	THR184
K	SER189

---

site_id	EC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO B 606

Chain	Residue
B	GLN116
B	GLY117
B	THR119

---

site_id	EC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO B 607

Chain	Residue
A	LEU102
A	THR103
A	PHE104
B	TRP49
B	ASP63

---

site_id	EC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO B 616

Chain	Residue
B	ASP58
B	ALA74
B	THR76

---

site_id	EC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO B 624

Chain	Residue
B	ASN57
B	ASP58

---

site_id	EC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL B 701

Chain	Residue
B	GLY10
B	ALA11
B	GLU12

---

site_id	EC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL B 704

Chain	Residue
B	ALA209
B	HIS210
B	SER214
B	THR215
B	LYS216

---

site_id	EC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO K 601

Chain	Residue
H	PRO129
K	VAL132
K	LYS219

---

site_id	EC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO K 608

Chain	Residue
K	ALA11
K	GLU12

---

site_id	EC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO K 611

Chain	Residue
J	SER122
K	MET146
K	VAL147
K	THR148

---

site_id	FC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO K 612

Chain	Residue
K	GLN67
K	GLY68
K	ALA70
K	THR71

---

site_id	FC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL K 706

Chain	Residue
C	THR20
C	MET21
K	GLN67
K	GLY68

---

site_id	FC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL K 707

Chain	Residue
K	GLN7
K	GLN8
K	SER9
K	SER23
K	THR25

---

site_id	FC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL K 904

Chain	Residue
K	GLN116

---

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH

Chain	Residue	Details
C	TYR198-HIS204

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	712
Details	Domain: {"description":"VWFA","evidences":[{"source":"PROSITE-ProRule","id":"PRU00219","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---