3Q0G

Crystal Structure of the Mycobacterium tuberculosis Crotonase Bound to a Reaction Intermediate Derived from Crotonyl CoA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004300	molecular_function	enoyl-CoA hydratase activity
A	0005886	cellular_component	plasma membrane
A	0006635	biological_process	fatty acid beta-oxidation
A	0016836	molecular_function	hydro-lyase activity
A	0018812	molecular_function	3-hydroxyacyl-CoA dehydratase activity
B	0003824	molecular_function	catalytic activity
B	0004300	molecular_function	enoyl-CoA hydratase activity
B	0005886	cellular_component	plasma membrane
B	0006635	biological_process	fatty acid beta-oxidation
B	0016836	molecular_function	hydro-lyase activity
B	0018812	molecular_function	3-hydroxyacyl-CoA dehydratase activity
C	0003824	molecular_function	catalytic activity
C	0004300	molecular_function	enoyl-CoA hydratase activity
C	0005886	cellular_component	plasma membrane
C	0006635	biological_process	fatty acid beta-oxidation
C	0016836	molecular_function	hydro-lyase activity
C	0018812	molecular_function	3-hydroxyacyl-CoA dehydratase activity
D	0003824	molecular_function	catalytic activity
D	0004300	molecular_function	enoyl-CoA hydratase activity
D	0005886	cellular_component	plasma membrane
D	0006635	biological_process	fatty acid beta-oxidation
D	0016836	molecular_function	hydro-lyase activity
D	0018812	molecular_function	3-hydroxyacyl-CoA dehydratase activity
E	0003824	molecular_function	catalytic activity
E	0004300	molecular_function	enoyl-CoA hydratase activity
E	0005886	cellular_component	plasma membrane
E	0006635	biological_process	fatty acid beta-oxidation
E	0016836	molecular_function	hydro-lyase activity
E	0018812	molecular_function	3-hydroxyacyl-CoA dehydratase activity
F	0003824	molecular_function	catalytic activity
F	0004300	molecular_function	enoyl-CoA hydratase activity
F	0005886	cellular_component	plasma membrane
F	0006635	biological_process	fatty acid beta-oxidation
F	0016836	molecular_function	hydro-lyase activity
F	0018812	molecular_function	3-hydroxyacyl-CoA dehydratase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG A 258

Chain	Residue
C	COA258

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site_id	AC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL A 401

Chain	Residue
B	PHE230
A	ALA65
A	PHE84
A	GLU111
A	LEU137
A	PRO138
A	GLY139
A	HOH612
A	HOH613

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site_id	AC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL B 402

Chain	Residue
B	PHE84
B	GLU111
B	GLU131
B	VAL136
B	LEU137
B	PRO138
B	GLY139
B	HOH623
C	PHE230

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site_id	AC4
Number of Residues	18
Details	BINDING SITE FOR RESIDUE COA C 258

Chain	Residue
A	PHE246
A	LYS249
A	MG258
C	GLN23
C	LEU25
C	ALA27
C	ALA63
C	ALA65
C	ASP66
C	ILE67
C	LYS68
C	LEU106
C	PRO130
C	GLU131
C	LEU134
C	HOH553
C	HOH635
C	HOH639

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site_id	AC5
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL D 403

Chain	Residue
D	ALA65
D	GLU111
D	GLU131
D	VAL136
D	LEU137
D	GLY139
D	MET140
D	HOH502
E	PHE230

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site_id	AC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG F 258

Chain	Residue
F	BCO259

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site_id	AC7
Number of Residues	15
Details	BINDING SITE FOR RESIDUE BCO F 259

Chain	Residue
D	PHE230
D	PHE246
D	HOH619
F	LEU25
F	ALA63
F	GLY64
F	ALA65
F	ASP66
F	ILE67
F	GLY108
F	PRO130
F	GLU131
F	LEU134
F	MG258
F	HOH1000

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Functional Information from PROSITE/UniProt

site_id	PS00166
Number of Residues	21
Details	ENOYL_COA_HYDRATASE Enoyl-CoA hydratase/isomerase signature. IAaVAGyalGGGcelaMmCDV

Chain	Residue	Details
A	ILE98-VAL118

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