3Q0E
Crystals Structure of Aspartate beta-Semialdehyde Dehydrogenase from Vibrio Cholerae with product of S-allyl-L-cysteine sulfoxide
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004073 | molecular_function | aspartate-semialdehyde dehydrogenase activity |
| A | 0006520 | biological_process | amino acid metabolic process |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0009085 | biological_process | lysine biosynthetic process |
| A | 0009086 | biological_process | methionine biosynthetic process |
| A | 0009088 | biological_process | threonine biosynthetic process |
| A | 0009089 | biological_process | lysine biosynthetic process via diaminopimelate |
| A | 0009097 | biological_process | isoleucine biosynthetic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| A | 0019877 | biological_process | diaminopimelate biosynthetic process |
| A | 0046983 | molecular_function | protein dimerization activity |
| A | 0050661 | molecular_function | NADP binding |
| A | 0051287 | molecular_function | NAD binding |
| A | 0071266 | biological_process | 'de novo' L-methionine biosynthetic process |
| B | 0004073 | molecular_function | aspartate-semialdehyde dehydrogenase activity |
| B | 0006520 | biological_process | amino acid metabolic process |
| B | 0008652 | biological_process | amino acid biosynthetic process |
| B | 0009085 | biological_process | lysine biosynthetic process |
| B | 0009086 | biological_process | methionine biosynthetic process |
| B | 0009088 | biological_process | threonine biosynthetic process |
| B | 0009089 | biological_process | lysine biosynthetic process via diaminopimelate |
| B | 0009097 | biological_process | isoleucine biosynthetic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| B | 0019877 | biological_process | diaminopimelate biosynthetic process |
| B | 0046983 | molecular_function | protein dimerization activity |
| B | 0050661 | molecular_function | NADP binding |
| B | 0051287 | molecular_function | NAD binding |
| B | 0071266 | biological_process | 'de novo' L-methionine biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CYS A 401 |
| Chain | Residue |
| A | ARG101 |
| A | ASN133 |
| A | CYS134 |
| A | GLU240 |
| A | LYS243 |
| A | GLN350 |
| A | HOH809 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 402 |
| Chain | Residue |
| A | THR36 |
| A | SER37 |
| A | HOH531 |
| A | HOH546 |
| A | ARG9 |
| A | SER35 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACT A 403 |
| Chain | Residue |
| A | ARG309 |
| A | HOH504 |
| A | HOH735 |
| B | LYS232 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 B 401 |
| Chain | Residue |
| B | ARG9 |
| B | SER35 |
| B | THR36 |
| B | SER37 |
| B | HOH548 |
| B | HOH787 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CYS B 402 |
| Chain | Residue |
| B | ARG101 |
| B | ASN133 |
| B | CYS134 |
| B | GLU240 |
| B | GLN350 |
| B | HOH632 |
| B | HOH706 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO B 403 |
| Chain | Residue |
| B | ARG19 |
| B | GLU22 |
| B | GLY323 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO B 404 |
| Chain | Residue |
| B | GLY10 |
| B | MET11 |
| B | GLY167 |
| B | ALA168 |
| B | HOH749 |
| B | HOH781 |
Functional Information from PROSITE/UniProt
| site_id | PS01103 |
| Number of Residues | 15 |
| Details | ASD Aspartate-semialdehyde dehydrogenase signature. IDgtCvRIgamrCHS |
| Chain | Residue | Details |
| A | ILE261-SER275 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Acyl-thioester intermediate => ECO:0000269|PubMed:12493825 |
| Chain | Residue | Details |
| A | CYS134 | |
| B | CYS134 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton acceptor => ECO:0000305|PubMed:12493825 |
| Chain | Residue | Details |
| A | HIS274 | |
| B | HIS274 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:12493825 |
| Chain | Residue | Details |
| A | ARG9 | |
| B | SER164 | |
| B | PRO192 | |
| B | GLN350 | |
| A | THR36 | |
| A | GLN72 | |
| A | SER164 | |
| A | PRO192 | |
| A | GLN350 | |
| B | ARG9 | |
| B | THR36 | |
| B | GLN72 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_02121 |
| Chain | Residue | Details |
| A | ARG101 | |
| A | LYS243 | |
| B | ARG101 | |
| B | LYS243 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:12493825 |
| Chain | Residue | Details |
| A | GLN161 | |
| A | GLU240 | |
| A | ARG267 | |
| B | GLN161 | |
| B | GLU240 | |
| B | ARG267 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: S-cysteinyl cysteine; in inhibited form |
| Chain | Residue | Details |
| A | CYS134 | |
| B | CYS134 |
