3PZR
Crystals structure of aspartate beta-Semialdehyde dehydrogenase from Vibrio Cholerae with NADP and product of S-carbamoyl-L-cysteine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004073 | molecular_function | aspartate-semialdehyde dehydrogenase activity |
| A | 0006520 | biological_process | amino acid metabolic process |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0009067 | biological_process | aspartate family amino acid biosynthetic process |
| A | 0009085 | biological_process | lysine biosynthetic process |
| A | 0009086 | biological_process | methionine biosynthetic process |
| A | 0009088 | biological_process | threonine biosynthetic process |
| A | 0009089 | biological_process | lysine biosynthetic process via diaminopimelate |
| A | 0009097 | biological_process | isoleucine biosynthetic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| A | 0019877 | biological_process | diaminopimelate biosynthetic process |
| A | 0046983 | molecular_function | protein dimerization activity |
| A | 0050661 | molecular_function | NADP binding |
| A | 0051287 | molecular_function | NAD binding |
| A | 0071266 | biological_process | 'de novo' L-methionine biosynthetic process |
| B | 0004073 | molecular_function | aspartate-semialdehyde dehydrogenase activity |
| B | 0006520 | biological_process | amino acid metabolic process |
| B | 0008652 | biological_process | amino acid biosynthetic process |
| B | 0009067 | biological_process | aspartate family amino acid biosynthetic process |
| B | 0009085 | biological_process | lysine biosynthetic process |
| B | 0009086 | biological_process | methionine biosynthetic process |
| B | 0009088 | biological_process | threonine biosynthetic process |
| B | 0009089 | biological_process | lysine biosynthetic process via diaminopimelate |
| B | 0009097 | biological_process | isoleucine biosynthetic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| B | 0019877 | biological_process | diaminopimelate biosynthetic process |
| B | 0046983 | molecular_function | protein dimerization activity |
| B | 0050661 | molecular_function | NADP binding |
| B | 0051287 | molecular_function | NAD binding |
| B | 0071266 | biological_process | 'de novo' L-methionine biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE CYS A 371 |
| Chain | Residue |
| A | ASN133 |
| A | HOH623 |
| A | CYS134 |
| A | GLN161 |
| A | GLY165 |
| A | ILE229 |
| A | GLU240 |
| A | ARG267 |
| A | HIS274 |
| A | GLN350 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE CYS B 371 |
| Chain | Residue |
| B | CYS134 |
| B | GLN161 |
| B | GLY165 |
| B | GLU240 |
| B | ARG267 |
| B | HIS274 |
| B | GLN350 |
| B | NAP372 |
| B | HOH639 |
| site_id | AC3 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE NAP A 372 |
| Chain | Residue |
| A | GLY7 |
| A | ARG9 |
| A | GLY10 |
| A | MET11 |
| A | VAL12 |
| A | SER35 |
| A | THR36 |
| A | SER37 |
| A | CYS71 |
| A | GLN72 |
| A | HOH387 |
| A | HOH394 |
| A | HOH410 |
| A | HOH423 |
| A | HOH446 |
| A | HOH500 |
| A | HOH551 |
| A | HOH610 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA A 373 |
| Chain | Residue |
| A | GLY210 |
| A | PHE212 |
| A | THR214 |
| A | HOH437 |
| A | HOH441 |
| B | HOH375 |
| site_id | AC5 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE NAP B 372 |
| Chain | Residue |
| B | GLY7 |
| B | ARG9 |
| B | GLY10 |
| B | MET11 |
| B | VAL12 |
| B | THR36 |
| B | SER37 |
| B | CYS71 |
| B | GLN72 |
| B | GLY73 |
| B | ALA97 |
| B | GLY165 |
| B | GLN350 |
| B | CYS371 |
| B | HOH378 |
| B | HOH381 |
| B | HOH539 |
| B | HOH550 |
| B | HOH552 |
| B | HOH603 |
| B | HOH639 |
| B | HOH646 |
| B | HOH654 |
| B | HOH713 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA B 373 |
| Chain | Residue |
| B | GLY210 |
| B | PHE212 |
| B | HOH438 |
| B | HOH445 |
| B | HOH454 |
| B | HOH458 |
Functional Information from PROSITE/UniProt
| site_id | PS01103 |
| Number of Residues | 15 |
| Details | ASD Aspartate-semialdehyde dehydrogenase signature. IDgtCvRIgamrCHS |
| Chain | Residue | Details |
| A | ILE261-SER275 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Acyl-thioester intermediate","evidences":[{"source":"PubMed","id":"12493825","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"12493825","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"12493825","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_02121","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"12493825","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"S-cysteinyl cysteine; in inhibited form"} |
| Chain | Residue | Details |
