3PZK

Crystal Structure of the Mycobacterium tuberculosis crotonase in apo form

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004300	molecular_function	enoyl-CoA hydratase activity
A	0005886	cellular_component	plasma membrane
A	0006629	biological_process	lipid metabolic process
A	0006631	biological_process	fatty acid metabolic process
A	0006635	biological_process	fatty acid beta-oxidation
A	0009274	cellular_component	peptidoglycan-based cell wall
A	0016829	molecular_function	lyase activity
A	0016836	molecular_function	hydro-lyase activity
A	0018812	molecular_function	3-hydroxyacyl-CoA dehydratase activity
B	0003824	molecular_function	catalytic activity
B	0004300	molecular_function	enoyl-CoA hydratase activity
B	0005886	cellular_component	plasma membrane
B	0006629	biological_process	lipid metabolic process
B	0006631	biological_process	fatty acid metabolic process
B	0006635	biological_process	fatty acid beta-oxidation
B	0009274	cellular_component	peptidoglycan-based cell wall
B	0016829	molecular_function	lyase activity
B	0016836	molecular_function	hydro-lyase activity
B	0018812	molecular_function	3-hydroxyacyl-CoA dehydratase activity
C	0003824	molecular_function	catalytic activity
C	0004300	molecular_function	enoyl-CoA hydratase activity
C	0005886	cellular_component	plasma membrane
C	0006629	biological_process	lipid metabolic process
C	0006631	biological_process	fatty acid metabolic process
C	0006635	biological_process	fatty acid beta-oxidation
C	0009274	cellular_component	peptidoglycan-based cell wall
C	0016829	molecular_function	lyase activity
C	0016836	molecular_function	hydro-lyase activity
C	0018812	molecular_function	3-hydroxyacyl-CoA dehydratase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE SO4 A 258

Chain	Residue
A	ALA65
A	HOH271
B	PHE230
A	PHE84
A	GLY108
A	GLU111
A	GLU131
A	LEU137
A	PRO138
A	GLY139
A	MET140

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site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 B 258

Chain	Residue
A	ALA149
B	ARG148
B	ALA149
B	HOH419
C	ALA149

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Functional Information from PROSITE/UniProt

site_id	PS00166
Number of Residues	21
Details	ENOYL_COA_HYDRATASE Enoyl-CoA hydratase/isomerase signature. IAaVAGyalGGGcelaMmCDV

Chain	Residue	Details
A	ILE98-VAL118

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