3PVK

Secreted aspartic protease 2 in complex with benzamidine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004190	molecular_function	aspartic-type endopeptidase activity
A	0005576	cellular_component	extracellular region
A	0006508	biological_process	proteolysis
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1001

Chain	Residue
A	ASP57
A	GLU324
A	IMD4002
A	IMD4003

---

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE BEN A 2001

Chain	Residue
A	BEN3001
A	MPD4001
A	TYR84
A	ASP86
A	GLY220
A	THR221
A	ILE305

---

site_id	AC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE BEN A 3001

Chain	Residue
A	ASP32
A	GLY34
A	SER35
A	TYR84
A	LEU216
A	ASP218
A	HOH375
A	BEN2001

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MPD A 4001

Chain	Residue
A	ILE30
A	ASP32
A	SER88
A	GLY220
A	BEN2001

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE IMD A 4002

Chain	Residue
A	ASP57
A	ASP322
A	GLU324
A	ZN1001
A	IMD4003

---

site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE IMD A 4003

Chain	Residue
A	THR55
A	ASP57
A	GLN61
A	GLU324
A	HOH606
A	ZN1001
A	IMD4002

---

Functional Information from PROSITE/UniProt

site_id	PS00141
Number of Residues	12
Details	ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. VIVDTGSSDLWV

Chain	Residue	Details
A	VAL29-VAL40
A	VAL215-LEU226

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10094

Chain	Residue	Details
A	ASP32
A	ASP218

---

site_id	SWS_FT_FI2
Number of Residues	5
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P0CY29

Chain	Residue	Details
A	ASP32
A	GLY85
A	ASP191
A	ASP214
A	ASP218

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN257
A	ASN265

---