3PU3
PHF2 Jumonji domain-NOG complex
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE OGA A 1 |
| Chain | Residue |
| A | THR193 |
| A | THR246 |
| A | HIS249 |
| A | ASP251 |
| A | TYR259 |
| A | THR323 |
| A | HIS335 |
| A | HOH506 |
| site_id | AC2 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE OGA B 2 |
| Chain | Residue |
| B | THR193 |
| B | LEU238 |
| B | CYS240 |
| B | THR246 |
| B | HIS249 |
| B | ASP251 |
| B | TYR259 |
| B | LYS266 |
| B | TYR321 |
| B | THR323 |
| B | EDO49 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO B 1 |
| Chain | Residue |
| B | SER317 |
| B | SER341 |
| B | HOH505 |
| B | HOH513 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE EDO B 452 |
| Chain | Residue |
| B | EDO4 |
| B | HOH19 |
| B | SER339 |
| B | LEU340 |
| B | SER341 |
| B | VAL342 |
| B | GLU343 |
| B | HIS394 |
| B | ILE401 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE EDO B 4 |
| Chain | Residue |
| B | GLU343 |
| B | EDO452 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO A 5 |
| Chain | Residue |
| A | EDO6 |
| A | LYS214 |
| A | LEU215 |
| A | TRP217 |
| A | ASN220 |
| A | TYR221 |
| A | SER339 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO A 6 |
| Chain | Residue |
| A | EDO5 |
| A | TYR221 |
| A | SER339 |
| A | MET373 |
| A | HIS376 |
| A | LEU395 |
| A | HOH511 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO B 7 |
| Chain | Residue |
| A | ARG107 |
| A | PRO130 |
| A | HOH472 |
| B | ASP179 |
| B | TYR182 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 9 |
| Chain | Residue |
| A | LYS375 |
| A | PHE426 |
| A | LYS427 |
| A | HOH537 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 10 |
| Chain | Residue |
| A | EDO20 |
| A | TYR221 |
| A | TYR372 |
| A | GLU379 |
| site_id | BC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE EDO A 11 |
| Chain | Residue |
| A | EDO16 |
| A | PRO208 |
| A | VAL212 |
| A | THR234 |
| A | TRP258 |
| A | GLY334 |
| A | HIS335 |
| A | HOH484 |
| site_id | BC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 12 |
| Chain | Residue |
| A | SER198 |
| A | LYS230 |
| A | PRO231 |
| A | LYS232 |
| A | THR234 |
| A | HOH465 |
| A | HOH503 |
| site_id | BC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE EDO B 13 |
| Chain | Residue |
| B | TYR221 |
| B | TYR372 |
| site_id | BC5 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE EDO A 14 |
| Chain | Residue |
| A | HOH614 |
| site_id | BC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO A 16 |
| Chain | Residue |
| A | EDO11 |
| A | EDO24 |
| A | VAL212 |
| A | LYS213 |
| A | SER216 |
| A | GLU219 |
| A | HOH484 |
| site_id | BC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE EDO A 17 |
| Chain | Residue |
| A | SER408 |
| A | HIS418 |
| site_id | BC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 18 |
| Chain | Residue |
| A | ALA101 |
| A | GLU102 |
| A | VAL105 |
| A | ARG107 |
| A | HOH587 |
| site_id | BC9 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE EDO A 19 |
| Chain | Residue |
| B | ALA274 |
| B | ALA276 |
| B | ASN277 |
| B | HOH531 |
| A | GLU419 |
| A | LEU422 |
| A | PRO423 |
| A | GLU424 |
| A | HOH551 |
| A | HOH595 |
| site_id | CC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO A 20 |
| Chain | Residue |
| A | EDO10 |
| A | ASN220 |
| A | HOH604 |
| site_id | CC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO B 21 |
| Chain | Residue |
| A | GLU102 |
| B | TYR145 |
| B | VAL146 |
| B | TYR181 |
| B | TYR182 |
| B | HOH587 |
| site_id | CC3 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE EDO B 22 |
| Chain | Residue |
| B | PRO208 |
| B | VAL233 |
| B | THR234 |
| B | TRP258 |
| B | GLY334 |
| B | HIS335 |
| B | HOH461 |
| B | HOH469 |
| B | HOH618 |
| site_id | CC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 23 |
| Chain | Residue |
| A | MET293 |
| A | PHE294 |
| A | ASP297 |
| A | GLN298 |
| site_id | CC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 24 |
| Chain | Residue |
| A | EDO16 |
| A | VAL218 |
| A | GLU219 |
| A | LYS230 |
| A | THR234 |
| A | HOH484 |
| site_id | CC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 26 |
| Chain | Residue |
| A | HIS249 |
| A | ILE250 |
| A | THR361 |
| A | HOH501 |
| site_id | CC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO B 28 |
| Chain | Residue |
| B | HOH17 |
| B | ALA229 |
| B | ASN365 |
| site_id | CC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO B 29 |
| Chain | Residue |
| B | HOH17 |
| B | LYS230 |
| B | LYS232 |
| B | PRO364 |
| B | HOH493 |
| site_id | CC9 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE EDO B 30 |
| Chain | Residue |
| B | GLY404 |
| site_id | DC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO B 31 |
| Chain | Residue |
| A | HOH469 |
| A | HOH502 |
| B | GLU343 |
| B | MET344 |
| B | ARG347 |
| site_id | DC2 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE EDO A 33 |
| Chain | Residue |
| A | GLU119 |
| site_id | DC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE EDO A 34 |
| Chain | Residue |
| A | SER286 |
| A | LEU355 |
| site_id | DC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO A 35 |
| Chain | Residue |
| A | ASP300 |
| A | HOH486 |
| B | LYS427 |
| site_id | DC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE EDO A 36 |
| Chain | Residue |
| A | ARG407 |
| A | HOH573 |
| site_id | DC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO A 37 |
| Chain | Residue |
| A | ARG201 |
| A | HOH531 |
| A | HOH618 |
| site_id | DC7 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE EDO B 38 |
| Chain | Residue |
| B | LEU137 |
| site_id | DC8 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE EDO B 39 |
| Chain | Residue |
| B | ASP210 |
| site_id | DC9 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE EDO B 40 |
| Chain | Residue |
| B | HOH616 |
| site_id | EC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO B 41 |
| Chain | Residue |
| B | EDO43 |
| B | ARG283 |
| B | TRP284 |
| B | ALA287 |
| B | MET293 |
| B | GLN298 |
| B | HOH536 |
| site_id | EC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO A 42 |
| Chain | Residue |
| A | LEU93 |
| A | ARG94 |
| A | ARG96 |
| A | PHE98 |
| A | TYR269 |
| A | LYS304 |
| A | HOH558 |
| site_id | EC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO B 43 |
| Chain | Residue |
| B | EDO41 |
| B | LEU280 |
| B | ARG283 |
| B | TRP284 |
| B | GLN298 |
| site_id | EC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE EDO B 44 |
| Chain | Residue |
| B | GLU265 |
| site_id | EC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO B 45 |
| Chain | Residue |
| B | LEU115 |
| B | GLU119 |
| B | HIS394 |
| site_id | EC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 46 |
| Chain | Residue |
| A | PRO155 |
| A | GLU156 |
| A | LYS175 |
| B | LYS308 |
| site_id | EC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO B 47 |
| Chain | Residue |
| B | PRO223 |
| B | ASP225 |
| B | HOH462 |
| B | HOH535 |
| site_id | EC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO B 48 |
| Chain | Residue |
| B | ARG347 |
| B | GLU350 |
| B | ARG354 |
| site_id | EC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO B 49 |
| Chain | Residue |
| B | OGA2 |
| B | THR193 |
| B | ASN194 |
| B | TYR236 |
| B | HIS335 |
| B | THR361 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 312 |
| Details | Domain: {"description":"JmjC","evidences":[{"source":"PROSITE-ProRule","id":"PRU00538","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 10 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00538","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"21167174","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
