3PT9

Crystal structure of mouse DNMT1(731-1602) in the free state

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003682	molecular_function	chromatin binding
A	0008168	molecular_function	methyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	23
Details	BINDING SITE FOR RESIDUE SAH A 1603

Chain	Residue
A	HOH3
A	GLY1153
A	LEU1154
A	GLU1171
A	MET1172
A	TRP1173
A	GLU1192
A	ASP1193
A	CYS1194
A	GLY1226
A	PRO1228
A	HOH7
A	LEU1250
A	PRO1489
A	ALA1581
A	VAL1582
A	HOH39
A	HOH193
A	HOH315
A	PHE1148
A	SER1149
A	GLY1150
A	GLY1152

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1

Chain	Residue
A	CYS1479
A	CYS1481
A	CYS1487
A	HIS1504

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 2

Chain	Residue
A	HIS796
A	CYS823
A	CYS897
A	CYS900

---

Functional Information from PROSITE/UniProt

site_id	PS00094
Number of Residues	13
Details	C5_MTASE_1 C-5 cytosine-specific DNA methylases active site. EmLcgGpPCqGFS

Chain	Residue	Details
A	GLU1221-SER1233

---

site_id	PS00095
Number of Residues	19
Details	C5_MTASE_2 C-5 cytosine-specific DNA methylases C-terminal signature. RqvGNAVpPpLakaIgleI

Chain	Residue	Details
A	ARG1576-ILE1594

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: ACT_SITE => ECO:0000269|PubMed:17576694

Chain	Residue	Details
A	CYS1229

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:21163962, ECO:0007744|PDB:3PT6, ECO:0007744|PDB:4DA4

Chain	Residue	Details
A	SER1149

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:21163962, ECO:0007744|PDB:3PT6, ECO:0007744|PDB:3PT9, ECO:0007744|PDB:4DA4

Chain	Residue	Details
A	GLY1153
A	GLU1171
A	VAL1582

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:21163962, ECO:0007744|PDB:3PT6, ECO:0007744|PDB:3PT9

Chain	Residue	Details
A	ASP1193

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P26358

Chain	Residue	Details
A	SER735
A	SER882

---

site_id	SWS_FT_FI6
Number of Residues	11
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P26358

Chain	Residue	Details
A	LYS752
A	LYS1352
A	LYS1418
A	LYS895
A	LYS961
A	LYS965
A	LYS979
A	LYS1114
A	LYS1116
A	LYS1118
A	LYS1120

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:23806337

Chain	Residue	Details
A	LYS1122
A	LYS1124

---