Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004252 | molecular_function | serine-type endopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| B | 0004252 | molecular_function | serine-type endopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
| C | 0005576 | cellular_component | extracellular region |
| C | 0006508 | biological_process | proteolysis |
| C | 0008236 | molecular_function | serine-type peptidase activity |
| D | 0005576 | cellular_component | extracellular region |
| D | 0006508 | biological_process | proteolysis |
| D | 0008236 | molecular_function | serine-type peptidase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE AES A 199 |
| Chain | Residue |
| A | HIS36 |
| A | GLY161 |
| A | VAL163 |
| C | LYS162 |
| C | LEU163 |
| A | MET138 |
| A | GLY139 |
| A | ARG140 |
| A | ASP142 |
| A | SER143 |
| A | ALA158 |
| A | SER159 |
| A | GLY160 |
| site_id | AC2 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE AES B 199 |
| Chain | Residue |
| B | HIS36 |
| B | MET138 |
| B | GLY139 |
| B | ARG140 |
| B | ASP142 |
| B | SER143 |
| B | SER159 |
| B | GLY160 |
| B | GLY161 |
| B | VAL163 |
| B | HOH223 |
| D | LYS162 |
| D | LEU163 |
Functional Information from PROSITE/UniProt
| site_id | PS00134 |
| Number of Residues | 6 |
| Details | TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VTAGHC |
| Chain | Residue | Details |
| A | VAL32-CYS37 | |
| site_id | PS00135 |
| Number of Residues | 12 |
| Details | TRYPSIN_SER Serine proteases, trypsin family, serine active site. CMgrGDSGGSWI |
| Chain | Residue | Details |
| A | CYS137-ILE148 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | ACT_SITE: Charge relay system => ECO:0000250 |
| Chain | Residue | Details |
| A | HIS36 | |
| A | ASP63 | |
| A | SER143 | |
| B | HIS36 | |
| B | ASP63 | |
| B | SER143 | |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1ssx |
| Chain | Residue | Details |
| A | SER143 | |
| A | GLY141 | |
| A | ASP63 | |
| A | HIS36 | |
| A | SER159 | |
| site_id | CSA2 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1ssx |
| Chain | Residue | Details |
| B | SER143 | |
| B | GLY141 | |
| B | ASP63 | |
| B | HIS36 | |
| B | SER159 | |
| site_id | CSA3 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1ssx |
| Chain | Residue | Details |
| A | SER143 | |
| A | GLY141 | |
| A | ASP63 | |
| A | HIS36 | |
| site_id | CSA4 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1ssx |
| Chain | Residue | Details |
| B | SER143 | |
| B | GLY141 | |
| B | ASP63 | |
| B | HIS36 | |
| site_id | MCSA1 |
| Number of Residues | |
| Details | M-CSA 609 |
| Chain | Residue | Details |
| A | HIS36 | proton acceptor, proton donor |
| A | ASP63 | electrostatic stabiliser |
| A | GLY141 | electrostatic stabiliser |
| A | SER143 | electrostatic stabiliser |
| A | SER159 | electrostatic stabiliser |
| site_id | MCSA2 |
| Number of Residues | |
| Details | M-CSA 609 |
| Chain | Residue | Details |
| B | HIS36 | proton acceptor, proton donor |
| B | ASP63 | electrostatic stabiliser |
| B | GLY141 | electrostatic stabiliser |
| B | SER143 | electrostatic stabiliser |
| B | SER159 | electrostatic stabiliser |
