3PNB

Phosphopantetheine Adenylyltransferase from Mycobacterium tuberculosis in complex with coenzyme A

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003824	molecular_function	catalytic activity
A	0004595	molecular_function	pantetheine-phosphate adenylyltransferase activity
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0009058	biological_process	biosynthetic process
A	0015937	biological_process	coenzyme A biosynthetic process
A	0016740	molecular_function	transferase activity
A	0016779	molecular_function	nucleotidyltransferase activity
A	0034214	biological_process	protein hexamerization
B	0000166	molecular_function	nucleotide binding
B	0003824	molecular_function	catalytic activity
B	0004595	molecular_function	pantetheine-phosphate adenylyltransferase activity
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0009058	biological_process	biosynthetic process
B	0015937	biological_process	coenzyme A biosynthetic process
B	0016740	molecular_function	transferase activity
B	0016779	molecular_function	nucleotidyltransferase activity
B	0034214	biological_process	protein hexamerization
C	0000166	molecular_function	nucleotide binding
C	0003824	molecular_function	catalytic activity
C	0004595	molecular_function	pantetheine-phosphate adenylyltransferase activity
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0009058	biological_process	biosynthetic process
C	0015937	biological_process	coenzyme A biosynthetic process
C	0016740	molecular_function	transferase activity
C	0016779	molecular_function	nucleotidyltransferase activity
C	0034214	biological_process	protein hexamerization
D	0000166	molecular_function	nucleotide binding
D	0003824	molecular_function	catalytic activity
D	0004595	molecular_function	pantetheine-phosphate adenylyltransferase activity
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0009058	biological_process	biosynthetic process
D	0015937	biological_process	coenzyme A biosynthetic process
D	0016740	molecular_function	transferase activity
D	0016779	molecular_function	nucleotidyltransferase activity
D	0034214	biological_process	protein hexamerization

Functional Information from PDB Data

site_id	AC1
Number of Residues	18
Details	BINDING SITE FOR RESIDUE COA A 162

Chain	Residue
A	GLY8
A	SER128
A	GLU132
A	HOH158
A	HOH160
A	HOH167
A	HOH186
A	HOH203
A	HOH212
A	HOH272
A	SER9
A	GLY71
A	LEU72
A	VAL73
A	LYS87
A	ASP94
A	TYR97
A	ASN105

---

site_id	AC2
Number of Residues	17
Details	BINDING SITE FOR RESIDUE COA B 162

Chain	Residue
B	GLY8
B	SER9
B	GLY71
B	LEU72
B	VAL73
B	LYS87
B	ASP94
B	TYR97
B	ASN105
B	SER128
B	GLU132
B	HOH167
B	HOH172
B	HOH190
B	HOH198
B	HOH264
B	HOH301

---

site_id	AC3
Number of Residues	19
Details	BINDING SITE FOR RESIDUE COA C 162

Chain	Residue
C	GLY8
C	SER9
C	LEU36
C	GLY71
C	LEU72
C	VAL73
C	ASP94
C	TYR97
C	ASN105
C	SER128
C	GLU132
C	HOH166
C	HOH173
C	HOH181
C	HOH182
C	HOH189
C	HOH233
C	HOH265
C	HOH281

---

site_id	AC4
Number of Residues	19
Details	BINDING SITE FOR RESIDUE COA D 162

Chain	Residue
D	GLY8
D	SER9
D	GLY71
D	LEU72
D	VAL73
D	LYS87
D	ASP94
D	TYR97
D	ASN105
D	SER128
D	GLU132
D	HOH169
D	HOH170
D	HOH178
D	HOH186
D	HOH230
D	HOH295
D	HOH555
D	HOH565

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	40
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00151","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"23151631","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20851704","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"3NBA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3UC5","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00151","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"20851704","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3NBK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00151","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00151","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"23151631","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3UC5","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20851704","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3NBK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23151631","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20851704","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"3NBA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3UC5","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	Site: {"description":"Transition state stabilizer","evidences":[{"source":"HAMAP-Rule","id":"MF_00151","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	Modified residue: {"description":"N-acetylthreonine","evidences":[{"source":"PubMed","id":"21969609","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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