3PL1

Determination of the crystal structure of the pyrazinamidase from M.tuberculosis : a structure-function analysis for prediction resistance to pyrazinamide.

Replaces:  3GBC

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006769	biological_process	nicotinamide metabolic process
A	0006805	biological_process	xenobiotic metabolic process
A	0008198	molecular_function	ferrous iron binding
A	0008936	molecular_function	nicotinamidase activity
A	0016787	molecular_function	hydrolase activity
A	0019363	biological_process	pyridine nucleotide biosynthetic process
A	0030145	molecular_function	manganese ion binding
A	0046677	biological_process	response to antibiotic
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE FE2 A 188

Chain	Residue
A	ASP49
A	HIS51
A	HIS57
A	HIS71
A	HOH220
A	HOH221

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"21283666","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"evidences":[{"source":"PubMed","id":"21283666","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	1
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"21283666","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21283666","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3PL1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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