3PL1
Determination of the crystal structure of the pyrazinamidase from M.tuberculosis : a structure-function analysis for prediction resistance to pyrazinamide.
Replaces: 3GBCFunctional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006769 | biological_process | nicotinamide metabolic process |
| A | 0006805 | biological_process | xenobiotic metabolic process |
| A | 0008198 | molecular_function | ferrous iron binding |
| A | 0008936 | molecular_function | nicotinamidase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0019363 | biological_process | pyridine nucleotide biosynthetic process |
| A | 0030145 | molecular_function | manganese ion binding |
| A | 0046677 | biological_process | response to antibiotic |
| A | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE FE2 A 188 |
| Chain | Residue |
| A | ASP49 |
| A | HIS51 |
| A | HIS57 |
| A | HIS71 |
| A | HOH220 |
| A | HOH221 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton acceptor => ECO:0000305|PubMed:21283666 |
| Chain | Residue | Details |
| A | ASP8 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | ACT_SITE: ACT_SITE => ECO:0000305|PubMed:21283666 |
| Chain | Residue | Details |
| A | LYS96 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | ACT_SITE: Nucleophile => ECO:0000305|PubMed:21283666 |
| Chain | Residue | Details |
| A | CYS138 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:21283666, ECO:0007744|PDB:3PL1 |
| Chain | Residue | Details |
| A | ASP49 | |
| A | HIS51 | |
| A | HIS57 | |
| A | HIS71 |
