Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3PKZ

Structural basis for catalytic activation of a serine recombinase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000150	molecular_function	DNA strand exchange activity
A	0003677	molecular_function	DNA binding
A	0006310	biological_process	DNA recombination
B	0000150	molecular_function	DNA strand exchange activity
B	0003677	molecular_function	DNA binding
B	0006310	biological_process	DNA recombination
C	0000150	molecular_function	DNA strand exchange activity
C	0003677	molecular_function	DNA binding
C	0006310	biological_process	DNA recombination
D	0000150	molecular_function	DNA strand exchange activity
D	0003677	molecular_function	DNA binding
D	0006310	biological_process	DNA recombination
E	0000150	molecular_function	DNA strand exchange activity
E	0003677	molecular_function	DNA binding
E	0006310	biological_process	DNA recombination
F	0000150	molecular_function	DNA strand exchange activity
F	0003677	molecular_function	DNA binding
F	0006310	biological_process	DNA recombination
G	0000150	molecular_function	DNA strand exchange activity
G	0003677	molecular_function	DNA binding
G	0006310	biological_process	DNA recombination
H	0000150	molecular_function	DNA strand exchange activity
H	0003677	molecular_function	DNA binding
H	0006310	biological_process	DNA recombination
I	0000150	molecular_function	DNA strand exchange activity
I	0003677	molecular_function	DNA binding
I	0006310	biological_process	DNA recombination
J	0000150	molecular_function	DNA strand exchange activity
J	0003677	molecular_function	DNA binding
J	0006310	biological_process	DNA recombination
K	0000150	molecular_function	DNA strand exchange activity
K	0003677	molecular_function	DNA binding
K	0006310	biological_process	DNA recombination
L	0000150	molecular_function	DNA strand exchange activity
L	0003677	molecular_function	DNA binding
L	0006310	biological_process	DNA recombination

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 125

Chain	Residue
A	ARG7
A	SER9
A	ARG66
A	ARG69
A	HOH428

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 126

Chain	Residue
A	ASN51
A	TYR80
A	LYS84
F	LYS48

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 B 125

Chain	Residue
B	ARG7
B	SER9
B	GLN13
B	ARG66
B	ARG69
B	HOH228

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 C 125

Chain	Residue
A	ILE75
A	ASN79
A	ARG115
C	ILE75
C	ASN79
C	ARG115
C	HOH613

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 C 126

Chain	Residue
C	ARG7
C	SER9
C	GLN13
C	ARG66
C	ARG69
C	HOH808

site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 D 125

Chain	Residue
B	ASN79
B	ARG115
D	ASN79
D	LYS82
D	ASP111
D	ARG115
D	HOH629

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 D 126

Chain	Residue
D	ARG7
D	SER9
D	GLN13
D	ARG66
D	ARG69
D	HOH297

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 E 125

Chain	Residue
E	ARG7
E	SER9
E	GLN13
E	ARG66
E	ARG69

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 E 126

Chain	Residue
E	ILE75
E	ASN79
E	ARG115
G	ILE75
G	ASN79
G	ARG115

site_id	BC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 F 125

Chain	Residue
F	ARG7
F	SER9
F	GLN13
F	ARG66
F	ARG69
F	HOH339

site_id	BC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 G 125

Chain	Residue
G	ARG7
G	SER9
G	GLN13
G	ARG66
G	ARG69
G	HOH275

site_id	BC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 H 125

Chain	Residue
H	ARG7
H	SER9
H	GLN13
H	ARG66
H	ARG69
H	HOH345

site_id	BC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 H 126

Chain	Residue
F	ASN79
F	ARG115
H	ILE75
H	ASN79
H	ARG115
H	HOH496

site_id	BC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO H 127

Chain	Residue
H	ASN14
H	ARG17
H	HOH149
H	HOH900

site_id	BC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 I 125

Chain	Residue
I	ARG7
I	SER9
I	GLN13
I	ARG66
I	ARG69
I	HOH735

site_id	BC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 I 126

Chain	Residue
I	ILE75
I	ASN79
I	ARG115
K	ILE75
K	ASN79
K	ARG115

site_id	BC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 I 127

Chain	Residue
I	ASN51
I	TYR80
I	LYS84
I	HOH702
J	LYS48

site_id	BC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL I 128

Chain	Residue
I	MET95
I	LYS110
I	ILE114
I	EDO129
I	HOH335
I	GLN87
I	LEU88

site_id	CC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO I 129

Chain	Residue
I	GLN87
I	MET95
I	LYS110
I	GOL128
I	HOH723

site_id	CC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 J 125

Chain	Residue
J	ARG7
J	SER9
J	GLN13
J	ARG66
J	ARG69

site_id	CC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 K 125

Chain	Residue
K	ARG7
K	SER9
K	ARG66
K	ARG69

site_id	CC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL K 126

Chain	Residue
K	LEU11
K	GLN13
K	LEU15
K	HOH259
K	HOH340
K	HOH425

site_id	CC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 L 125

Chain	Residue
L	ARG7
L	SER9
L	GLN13
L	ARG66
L	ARG69
L	HOH285

site_id	CC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 L 126

Chain	Residue
J	ASN79
J	ASP111
J	HOH728
L	ASN79
L	ARG115

Functional Information from PROSITE/UniProt

site_id	PS00397
Number of Residues	9
Details	RECOMBINASES_1 Site-specific recombinases active site. YARVSSldQ

Chain	Residue	Details
A	TYR5-GLN13

site_id	PS00398
Number of Residues	13
Details	RECOMBINASES_2 Site-specific recombinases signature 2. GDrfIVeSIDRLG

Chain	Residue	Details
A	GLY56-GLY68

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	ACT_SITE: O-(5'-phospho-DNA)-serine intermediate => ECO:0000255\|PROSITE-ProRule:PRU01072

Chain	Residue	Details
A	SER9
J	SER9
K	SER9
L	SER9
B	SER9
C	SER9
D	SER9
E	SER9
F	SER9
G	SER9
H	SER9
I	SER9

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)