3PKB
M. tuberculosis MetAP with bengamide analog Y16, in Mn form
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004177 | molecular_function | aminopeptidase activity |
| A | 0004239 | molecular_function | initiator methionyl aminopeptidase activity |
| A | 0005506 | molecular_function | iron ion binding |
| A | 0005829 | cellular_component | cytosol |
| A | 0006508 | biological_process | proteolysis |
| A | 0008233 | molecular_function | peptidase activity |
| A | 0016485 | biological_process | protein processing |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0050897 | molecular_function | cobalt ion binding |
| A | 0070006 | molecular_function | metalloaminopeptidase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE Y16 A 286 |
| Chain | Residue |
| A | TYR97 |
| A | HIS212 |
| A | GLU238 |
| A | GLU269 |
| A | MN287 |
| A | MN288 |
| A | HOH312 |
| A | HOH417 |
| A | CYS105 |
| A | HIS114 |
| A | ASP131 |
| A | ASP142 |
| A | PHE202 |
| A | THR203 |
| A | HIS205 |
| A | PHE211 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN A 287 |
| Chain | Residue |
| A | ASP142 |
| A | HIS205 |
| A | GLU238 |
| A | GLU269 |
| A | Y16286 |
| A | MN288 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN A 288 |
| Chain | Residue |
| A | ASP131 |
| A | ASP142 |
| A | GLU269 |
| A | Y16286 |
| A | MN287 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 289 |
| Chain | Residue |
| A | ASN20 |
| A | ARG200 |
| A | HOH354 |
| A | HOH405 |
| A | HOH452 |
| A | HOH466 |
Functional Information from PROSITE/UniProt
| site_id | PS00680 |
| Number of Residues | 19 |
| Details | MAP_1 Methionine aminopeptidase subfamily 1 signature. FtGHGIGttfHnglvVl.HY |
| Chain | Residue | Details |
| A | PHE202-TYR220 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 7 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01974","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"15882055","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20038112","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21465667","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
