3PHW
OTU Domain of Crimean Congo Hemorrhagic Fever Virus in complex with Ubiquitin
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NEH B 76 |
| Chain | Residue |
| A | ASP37 |
| A | GLY38 |
| A | CYS40 |
| A | TRP99 |
| A | THR150 |
| B | GLY75 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NEH D 76 |
| Chain | Residue |
| C | THR150 |
| C | HIS151 |
| D | GLY75 |
| C | ASP37 |
| C | CYS40 |
| C | TRP99 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NEH F 76 |
| Chain | Residue |
| E | ASP37 |
| E | CYS40 |
| E | TRP99 |
| E | THR150 |
| F | GLY75 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE NEH H 76 |
| Chain | Residue |
| B | ASP39 |
| G | ASP37 |
| G | GLY38 |
| G | CYS40 |
| G | TRP99 |
| G | THR150 |
| H | GLY75 |
Functional Information from PROSITE/UniProt
| site_id | PS00299 |
| Number of Residues | 26 |
| Details | UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD |
| Chain | Residue | Details |
| B | LYS27-ASP52 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | SITE: Interacts with activating enzyme |
| Chain | Residue | Details |
| B | ARG54 | |
| B | ARG72 | |
| D | ARG54 | |
| D | ARG72 | |
| F | ARG54 | |
| F | ARG72 | |
| H | ARG54 | |
| H | ARG72 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | SITE: Essential for function |
| Chain | Residue | Details |
| B | HIS68 | |
| D | HIS68 | |
| F | HIS68 | |
| H | HIS68 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine; by PINK1 => ECO:0000269|PubMed:24660806, ECO:0000269|PubMed:24751536, ECO:0000269|PubMed:24784582, ECO:0000269|PubMed:25527291 |
| Chain | Residue | Details |
| B | SER65 | |
| D | SER65 | |
| F | SER65 | |
| H | SER65 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | MOD_RES: (Microbial infection) ADP-ribosylthreonine => ECO:0000269|PubMed:32330457 |
| Chain | Residue | Details |
| B | THR66 | |
| D | THR66 | |
| F | THR66 | |
| H | THR66 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603 |
| Chain | Residue | Details |
| B | LYS6 | |
| D | LYS6 | |
| F | LYS6 | |
| H | LYS6 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 8 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:18719106 |
| Chain | Residue | Details |
| B | LYS63 | |
| D | LYS63 | |
| F | LYS63 | |
| H | LYS63 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 8 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:16543144 |
| Chain | Residue | Details |
| B | LYS11 | |
| B | LYS48 | |
| D | LYS11 | |
| D | LYS48 | |
| F | LYS11 | |
| F | LYS48 | |
| H | LYS11 | |
| H | LYS48 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 4 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:15466860 |
| Chain | Residue | Details |
| B | LYS27 | |
| D | LYS27 | |
| F | LYS27 | |
| H | LYS27 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 4 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:25752573, ECO:0000269|PubMed:25752577, ECO:0000269|PubMed:34239127 |
| Chain | Residue | Details |
| B | LYS29 | |
| D | LYS29 | |
| F | LYS29 | |
| H | LYS29 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 4 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:25752577 |
| Chain | Residue | Details |
| B | LYS33 | |
| D | LYS33 | |
| F | LYS33 | |
| H | LYS33 |
