3PGY
Serine hydroxymethyltransferase from Staphylococcus aureus, S95P mutant.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004372 | molecular_function | glycine hydroxymethyltransferase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006544 | biological_process | glycine metabolic process |
| A | 0006545 | biological_process | glycine biosynthetic process |
| A | 0006563 | biological_process | L-serine metabolic process |
| A | 0006730 | biological_process | one-carbon metabolic process |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0019264 | biological_process | glycine biosynthetic process from serine |
| A | 0030170 | molecular_function | pyridoxal phosphate binding |
| A | 0035999 | biological_process | tetrahydrofolate interconversion |
| A | 0046653 | biological_process | tetrahydrofolate metabolic process |
| B | 0004372 | molecular_function | glycine hydroxymethyltransferase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006544 | biological_process | glycine metabolic process |
| B | 0006545 | biological_process | glycine biosynthetic process |
| B | 0006563 | biological_process | L-serine metabolic process |
| B | 0006730 | biological_process | one-carbon metabolic process |
| B | 0008652 | biological_process | amino acid biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0019264 | biological_process | glycine biosynthetic process from serine |
| B | 0030170 | molecular_function | pyridoxal phosphate binding |
| B | 0035999 | biological_process | tetrahydrofolate interconversion |
| B | 0046653 | biological_process | tetrahydrofolate metabolic process |
| C | 0004372 | molecular_function | glycine hydroxymethyltransferase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006544 | biological_process | glycine metabolic process |
| C | 0006545 | biological_process | glycine biosynthetic process |
| C | 0006563 | biological_process | L-serine metabolic process |
| C | 0006730 | biological_process | one-carbon metabolic process |
| C | 0008652 | biological_process | amino acid biosynthetic process |
| C | 0016740 | molecular_function | transferase activity |
| C | 0019264 | biological_process | glycine biosynthetic process from serine |
| C | 0030170 | molecular_function | pyridoxal phosphate binding |
| C | 0035999 | biological_process | tetrahydrofolate interconversion |
| C | 0046653 | biological_process | tetrahydrofolate metabolic process |
| D | 0004372 | molecular_function | glycine hydroxymethyltransferase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0006544 | biological_process | glycine metabolic process |
| D | 0006545 | biological_process | glycine biosynthetic process |
| D | 0006563 | biological_process | L-serine metabolic process |
| D | 0006730 | biological_process | one-carbon metabolic process |
| D | 0008652 | biological_process | amino acid biosynthetic process |
| D | 0016740 | molecular_function | transferase activity |
| D | 0019264 | biological_process | glycine biosynthetic process from serine |
| D | 0030170 | molecular_function | pyridoxal phosphate binding |
| D | 0035999 | biological_process | tetrahydrofolate interconversion |
| D | 0046653 | biological_process | tetrahydrofolate metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE CIT B 501 |
| Chain | Residue |
| A | TYR51 |
| B | HOH424 |
| B | HOH791 |
| A | GLY256 |
| A | GLY257 |
| B | GLY94 |
| B | PRO95 |
| B | THR223 |
| B | HIS225 |
| B | LYS226 |
| B | ARG232 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CIT B 502 |
| Chain | Residue |
| B | ILE75 |
| B | LYS79 |
| B | GLU85 |
| B | HIS86 |
| B | VAL87 |
| B | GLU240 |
| B | LYS243 |
| site_id | AC3 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE CIT D 503 |
| Chain | Residue |
| C | GLY94 |
| C | PRO95 |
| C | THR223 |
| C | HIS225 |
| C | LYS226 |
| C | ARG232 |
| C | HOH493 |
| D | TYR51 |
| D | GLU53 |
| D | GLY256 |
| D | GLY257 |
| D | HOH447 |
| D | HOH526 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE CIT D 504 |
| Chain | Residue |
| D | ILE75 |
| D | LYS79 |
| D | GLU85 |
| D | HIS86 |
| D | VAL87 |
| D | GLU240 |
| D | LYS243 |
| D | HOH898 |
| D | HOH1055 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CIT A 505 |
| Chain | Residue |
| A | ILE75 |
| A | LYS79 |
| A | GLU85 |
| A | HIS86 |
| A | VAL87 |
| A | GLU240 |
| A | LYS243 |
| site_id | AC6 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE CIT B 506 |
| Chain | Residue |
| A | GLY94 |
| A | PRO95 |
| A | THR223 |
| A | HIS225 |
| A | LYS226 |
| A | ARG232 |
| B | TYR51 |
| B | GLU53 |
| B | GLY256 |
| B | GLY257 |
| B | HOH417 |
| B | HOH438 |
| B | HOH468 |
| B | HOH522 |
| site_id | AC7 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE CIT D 507 |
| Chain | Residue |
| C | GLU53 |
| C | GLY256 |
| C | GLY257 |
| D | GLY94 |
| D | PRO95 |
| D | THR223 |
| D | HIS225 |
| D | LYS226 |
| D | ARG232 |
| D | HOH438 |
| D | HOH643 |
| D | HOH800 |
| site_id | AC8 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE CIT C 508 |
| Chain | Residue |
| C | ILE75 |
| C | LYS79 |
| C | GLU85 |
| C | HIS86 |
| C | VAL87 |
| C | GLU240 |
| C | LYS243 |
| C | HOH801 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GLY B 509 |
| Chain | Residue |
| B | THR366 |
| B | LEU410 |
| B | TYR411 |
| B | HOH992 |
| site_id | BC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GLY A 510 |
| Chain | Residue |
| A | GLU27 |
| A | ASN33 |
| A | PHE34 |
| A | ALA363 |
| A | HOH469 |
| A | HOH804 |
| B | ASN49 |
| site_id | BC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GLY B 511 |
| Chain | Residue |
| B | SER334 |
| B | GLU391 |
| B | LEU394 |
| B | GLN395 |
| B | LYS398 |
| site_id | BC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO C 512 |
| Chain | Residue |
| C | GLU32 |
| C | HIS200 |
| C | LYS226 |
| D | TYR51 |
| C | ALA30 |
| C | SER31 |
| site_id | BC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO C 513 |
| Chain | Residue |
| A | ASP153 |
| C | GLU299 |
| C | SER382 |
| C | LEU383 |
| C | LYS386 |
| C | HOH446 |
| C | HOH492 |
Functional Information from PROSITE/UniProt
| site_id | PS00096 |
| Number of Residues | 17 |
| Details | SHMT Serine hydroxymethyltransferase pyridoxal-phosphate attachment site. DFvTTTTHKTLrGPRGG |
| Chain | Residue | Details |
| A | ASP218-GLY234 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00051","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Site: {"description":"Plays an important role in substrate specificity","evidences":[{"source":"HAMAP-Rule","id":"MF_00051","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"N6-(pyridoxal phosphate)lysine","evidences":[{"source":"HAMAP-Rule","id":"MF_00051","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
