3PGY
Serine hydroxymethyltransferase from Staphylococcus aureus, S95P mutant.
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003824 | molecular_function | catalytic activity |
A | 0004372 | molecular_function | glycine hydroxymethyltransferase activity |
A | 0005737 | cellular_component | cytoplasm |
A | 0006545 | biological_process | glycine biosynthetic process |
A | 0006730 | biological_process | one-carbon metabolic process |
A | 0008652 | biological_process | amino acid biosynthetic process |
A | 0016740 | molecular_function | transferase activity |
A | 0019264 | biological_process | glycine biosynthetic process from serine |
A | 0030170 | molecular_function | pyridoxal phosphate binding |
A | 0035999 | biological_process | tetrahydrofolate interconversion |
B | 0003824 | molecular_function | catalytic activity |
B | 0004372 | molecular_function | glycine hydroxymethyltransferase activity |
B | 0005737 | cellular_component | cytoplasm |
B | 0006545 | biological_process | glycine biosynthetic process |
B | 0006730 | biological_process | one-carbon metabolic process |
B | 0008652 | biological_process | amino acid biosynthetic process |
B | 0016740 | molecular_function | transferase activity |
B | 0019264 | biological_process | glycine biosynthetic process from serine |
B | 0030170 | molecular_function | pyridoxal phosphate binding |
B | 0035999 | biological_process | tetrahydrofolate interconversion |
C | 0003824 | molecular_function | catalytic activity |
C | 0004372 | molecular_function | glycine hydroxymethyltransferase activity |
C | 0005737 | cellular_component | cytoplasm |
C | 0006545 | biological_process | glycine biosynthetic process |
C | 0006730 | biological_process | one-carbon metabolic process |
C | 0008652 | biological_process | amino acid biosynthetic process |
C | 0016740 | molecular_function | transferase activity |
C | 0019264 | biological_process | glycine biosynthetic process from serine |
C | 0030170 | molecular_function | pyridoxal phosphate binding |
C | 0035999 | biological_process | tetrahydrofolate interconversion |
D | 0003824 | molecular_function | catalytic activity |
D | 0004372 | molecular_function | glycine hydroxymethyltransferase activity |
D | 0005737 | cellular_component | cytoplasm |
D | 0006545 | biological_process | glycine biosynthetic process |
D | 0006730 | biological_process | one-carbon metabolic process |
D | 0008652 | biological_process | amino acid biosynthetic process |
D | 0016740 | molecular_function | transferase activity |
D | 0019264 | biological_process | glycine biosynthetic process from serine |
D | 0030170 | molecular_function | pyridoxal phosphate binding |
D | 0035999 | biological_process | tetrahydrofolate interconversion |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE CIT B 501 |
Chain | Residue |
A | TYR51 |
B | HOH424 |
B | HOH791 |
A | GLY256 |
A | GLY257 |
B | GLY94 |
B | PRO95 |
B | THR223 |
B | HIS225 |
B | LYS226 |
B | ARG232 |
site_id | AC2 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE CIT B 502 |
Chain | Residue |
B | ILE75 |
B | LYS79 |
B | GLU85 |
B | HIS86 |
B | VAL87 |
B | GLU240 |
B | LYS243 |
site_id | AC3 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE CIT D 503 |
Chain | Residue |
C | GLY94 |
C | PRO95 |
C | THR223 |
C | HIS225 |
C | LYS226 |
C | ARG232 |
C | HOH493 |
D | TYR51 |
D | GLU53 |
D | GLY256 |
D | GLY257 |
D | HOH447 |
D | HOH526 |
site_id | AC4 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE CIT D 504 |
Chain | Residue |
D | ILE75 |
D | LYS79 |
D | GLU85 |
D | HIS86 |
D | VAL87 |
D | GLU240 |
D | LYS243 |
D | HOH898 |
D | HOH1055 |
site_id | AC5 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE CIT A 505 |
Chain | Residue |
A | ILE75 |
A | LYS79 |
A | GLU85 |
A | HIS86 |
A | VAL87 |
A | GLU240 |
A | LYS243 |
site_id | AC6 |
Number of Residues | 14 |
Details | BINDING SITE FOR RESIDUE CIT B 506 |
Chain | Residue |
A | GLY94 |
A | PRO95 |
A | THR223 |
A | HIS225 |
A | LYS226 |
A | ARG232 |
B | TYR51 |
B | GLU53 |
B | GLY256 |
B | GLY257 |
B | HOH417 |
B | HOH438 |
B | HOH468 |
B | HOH522 |
site_id | AC7 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE CIT D 507 |
Chain | Residue |
C | GLU53 |
C | GLY256 |
C | GLY257 |
D | GLY94 |
D | PRO95 |
D | THR223 |
D | HIS225 |
D | LYS226 |
D | ARG232 |
D | HOH438 |
D | HOH643 |
D | HOH800 |
site_id | AC8 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE CIT C 508 |
Chain | Residue |
C | ILE75 |
C | LYS79 |
C | GLU85 |
C | HIS86 |
C | VAL87 |
C | GLU240 |
C | LYS243 |
C | HOH801 |
site_id | AC9 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE GLY B 509 |
Chain | Residue |
B | THR366 |
B | LEU410 |
B | TYR411 |
B | HOH992 |
site_id | BC1 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE GLY A 510 |
Chain | Residue |
A | GLU27 |
A | ASN33 |
A | PHE34 |
A | ALA363 |
A | HOH469 |
A | HOH804 |
B | ASN49 |
site_id | BC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE GLY B 511 |
Chain | Residue |
B | SER334 |
B | GLU391 |
B | LEU394 |
B | GLN395 |
B | LYS398 |
site_id | BC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE EDO C 512 |
Chain | Residue |
C | GLU32 |
C | HIS200 |
C | LYS226 |
D | TYR51 |
C | ALA30 |
C | SER31 |
site_id | BC4 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE EDO C 513 |
Chain | Residue |
A | ASP153 |
C | GLU299 |
C | SER382 |
C | LEU383 |
C | LYS386 |
C | HOH446 |
C | HOH492 |
Functional Information from PROSITE/UniProt
site_id | PS00096 |
Number of Residues | 17 |
Details | SHMT Serine hydroxymethyltransferase pyridoxal-phosphate attachment site. DFvTTTTHKTLrGPRGG |
Chain | Residue | Details |
A | ASP218-GLY234 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 8 |
Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00051 |
Chain | Residue | Details |
A | LEU117 | |
A | GLY121 | |
B | LEU117 | |
B | GLY121 | |
C | LEU117 | |
C | GLY121 | |
D | LEU117 | |
D | GLY121 |
site_id | SWS_FT_FI2 |
Number of Residues | 4 |
Details | SITE: Plays an important role in substrate specificity => ECO:0000255|HAMAP-Rule:MF_00051 |
Chain | Residue | Details |
A | HIS225 | |
B | HIS225 | |
C | HIS225 | |
D | HIS225 |
site_id | SWS_FT_FI3 |
Number of Residues | 4 |
Details | MOD_RES: N6-(pyridoxal phosphate)lysine => ECO:0000255|HAMAP-Rule:MF_00051 |
Chain | Residue | Details |
A | LYS226 | |
B | LYS226 | |
C | LYS226 | |
D | LYS226 |