Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3PGM

THE STRUCTURE OF YEAST PHOSPHOGLYCERATE MUTASE AT 0.28 NM RESOLUTION

Replaces: 1PGM

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004619	molecular_function	phosphoglycerate mutase activity
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005741	cellular_component	mitochondrial outer membrane
A	0005758	cellular_component	mitochondrial intermembrane space
A	0005829	cellular_component	cytosol
A	0006094	biological_process	gluconeogenesis
A	0006096	biological_process	glycolytic process
A	0016853	molecular_function	isomerase activity
A	0016868	molecular_function	intramolecular phosphotransferase activity
A	0061621	biological_process	canonical glycolysis
B	0003824	molecular_function	catalytic activity
B	0004619	molecular_function	phosphoglycerate mutase activity
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005741	cellular_component	mitochondrial outer membrane
B	0005758	cellular_component	mitochondrial intermembrane space
B	0005829	cellular_component	cytosol
B	0006094	biological_process	gluconeogenesis
B	0006096	biological_process	glycolytic process
B	0016853	molecular_function	isomerase activity
B	0016868	molecular_function	intramolecular phosphotransferase activity
B	0061621	biological_process	canonical glycolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 245

Chain	Residue
A	HIS8
A	GLU86
A	HIS179
A	3PG247

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B 245

Chain	Residue
B	HIS8
B	GLU86
B	HIS179
B	3PG247

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 246

Chain	Residue
A	GLN10
A	SER11
A	ASN14
A	GLU15
A	THR20
A	3PG247
A	HIS8

site_id	AC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE 3PG A 247

Chain	Residue
A	HIS8
A	SER11
A	GLU15
A	THR20
A	GLU86
A	HIS179
A	SO4245
A	SO4246

site_id	AC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 B 246

Chain	Residue
B	HIS8
B	GLN10
B	SER11
B	ASN14
B	GLU15
B	THR20
B	3PG247

site_id	AC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE 3PG B 247

Chain	Residue
B	HIS8
B	SER11
B	GLU15
B	THR20
B	GLU86
B	HIS179
B	SO4245
B	SO4246

Functional Information from PROSITE/UniProt

site_id	PS00175
Number of Residues	10
Details	PG_MUTASE Phosphoglycerate mutase family phosphohistidine signature. LvRHGQsEwN

Chain	Residue	Details
A	LEU5-ASN14

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Tele-phosphohistidine intermediate","evidences":[{"source":"PubMed","id":"10064712","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10531478","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"6115412","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9512715","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	2
Details	Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"PubMed","id":"10064712","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10369755","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10531478","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"6115412","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10369755","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10531478","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10531478","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10369755","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"6115412","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10369755","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	2
Details	Site: {"description":"Transition state stabilizer","evidences":[{"source":"PubMed","id":"10064712","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17287358","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17287358","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"17330950","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	14
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"22106047","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	4
Details	Annotated By Reference To The Literature 1qhf

Chain	Residue	Details
A	HIS179
A	HIS8
A	GLU86
A	ARG59

site_id	CSA2
Number of Residues	4
Details	Annotated By Reference To The Literature 1qhf

Chain	Residue	Details
B	HIS179
B	HIS8
B	GLU86
B	ARG59

site_id	MCSA1
Number of Residues	4
Details	M-CSA 504

Chain	Residue	Details
A	HIS8	covalent catalysis
A	ARG59	electrostatic stabiliser
A	GLU86	proton donor, proton shuttle (general acid/base)
A	HIS179	electrostatic stabiliser

site_id	MCSA2
Number of Residues	4
Details	M-CSA 504

Chain	Residue	Details
B	HIS8	covalent catalysis
B	ARG59	electrostatic stabiliser
B	GLU86	proton donor, proton shuttle (general acid/base)
B	HIS179	electrostatic stabiliser

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)