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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

3PGJ

2.49 Angstrom resolution crystal structure of shikimate 5-dehydrogenase (aroE) from Vibrio cholerae O1 biovar eltor str. N16961 in complex with shikimate

Functional Information from GO Data
ChainGOidnamespacecontents
A0004764molecular_functionshikimate 3-dehydrogenase (NADP+) activity
A0005829cellular_componentcytosol
A0008652biological_processamino acid biosynthetic process
A0009073biological_processaromatic amino acid family biosynthetic process
A0009423biological_processchorismate biosynthetic process
A0016491molecular_functionoxidoreductase activity
A0019632biological_processshikimate metabolic process
A0050661molecular_functionNADP binding
B0004764molecular_functionshikimate 3-dehydrogenase (NADP+) activity
B0005829cellular_componentcytosol
B0008652biological_processamino acid biosynthetic process
B0009073biological_processaromatic amino acid family biosynthetic process
B0009423biological_processchorismate biosynthetic process
B0016491molecular_functionoxidoreductase activity
B0019632biological_processshikimate metabolic process
B0050661molecular_functionNADP binding
C0004764molecular_functionshikimate 3-dehydrogenase (NADP+) activity
C0005829cellular_componentcytosol
C0008652biological_processamino acid biosynthetic process
C0009073biological_processaromatic amino acid family biosynthetic process
C0009423biological_processchorismate biosynthetic process
C0016491molecular_functionoxidoreductase activity
C0019632biological_processshikimate metabolic process
C0050661molecular_functionNADP binding
D0004764molecular_functionshikimate 3-dehydrogenase (NADP+) activity
D0005829cellular_componentcytosol
D0008652biological_processamino acid biosynthetic process
D0009073biological_processaromatic amino acid family biosynthetic process
D0009423biological_processchorismate biosynthetic process
D0016491molecular_functionoxidoreductase activity
D0019632biological_processshikimate metabolic process
D0050661molecular_functionNADP binding
Functional Information from PDB Data
site_idAC1
Number of Residues9
DetailsBINDING SITE FOR RESIDUE SKM A 279
ChainResidue
ASER18
ASER20
AASN63
ATHR65
ALYS69
AASN90
AASP106
AGLN248
AHOH287
site_idAC2
Number of Residues10
DetailsBINDING SITE FOR RESIDUE SKM B 279
ChainResidue
BVAL10
BSER18
BSER20
BASN63
BTHR65
BLYS69
BASN90
BASP106
BGLN248
BHOH297
site_idAC3
Number of Residues9
DetailsBINDING SITE FOR RESIDUE SKM C 279
ChainResidue
CVAL10
CSER18
CSER20
CASN63
CTHR65
CLYS69
CASN90
CASP106
CGLN248
site_idAC4
Number of Residues8
DetailsBINDING SITE FOR RESIDUE SKM D 279
ChainResidue
DVAL10
DSER18
DSER20
DTHR65
DLYS69
DASN90
DASP106
DGLN248
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsActive site: {"description":"Proton acceptor","evidences":[{"source":"HAMAP-Rule","id":"MF_00222","evidenceCode":"ECO:0000255"},{"source":"Reference","evidenceCode":"ECO:0000305","citation":{"citationType":"submission","publicationDate":"NOV-2010","submissionDatabase":"PDB data bank","title":"2.49 Angstrom resolution crystal structure of shikimate 5-dehydrogenase (aroE) from Vibrio cholerae O1 biovar eltor str. N16961 in complex with shikimate.","authors":["Halavaty A.S.","Light S.H.","Shuvalova L.","Papazisi L.","Anderson W.F."]}},{"source":"Reference","evidenceCode":"ECO:0000305","citation":{"citationType":"submission","publicationDate":"JUN-2011","submissionDatabase":"PDB data bank","title":"2.4 Angstrom resolution crystal structure of shikimate 5-dehydrogenase (aroE) from Vibrio cholerae O1 biovar eltor str. N16961 in complex with shikimate and NADPH.","authors":["Halavaty A.S.","Light S.H.","Minasov G.","Shuvalova L.","Papazisi L.","Anderson W.F."]}}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues12
DetailsBinding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00222","evidenceCode":"ECO:0000255"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"NOV-2010","submissionDatabase":"PDB data bank","title":"2.49 Angstrom resolution crystal structure of shikimate 5-dehydrogenase (aroE) from Vibrio cholerae O1 biovar eltor str. N16961 in complex with shikimate.","authors":["Halavaty A.S.","Light S.H.","Shuvalova L.","Papazisi L.","Anderson W.F."]}},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUN-2011","submissionDatabase":"PDB data bank","title":"2.4 Angstrom resolution crystal structure of shikimate 5-dehydrogenase (aroE) from Vibrio cholerae O1 biovar eltor str. N16961 in complex with shikimate and NADPH.","authors":["Halavaty A.S.","Light S.H.","Minasov G.","Shuvalova L.","Papazisi L.","Anderson W.F."]}}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues32
DetailsBinding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00222","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues8
DetailsBinding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00222","evidenceCode":"ECO:0000255"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"NOV-2010","submissionDatabase":"PDB data bank","title":"2.49 Angstrom resolution crystal structure of shikimate 5-dehydrogenase (aroE) from Vibrio cholerae O1 biovar eltor str. N16961 in complex with shikimate.","authors":["Halavaty A.S.","Light S.H.","Shuvalova L.","Papazisi L.","Anderson W.F."]}}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues20
DetailsBinding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00222","evidenceCode":"ECO:0000255"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUN-2011","submissionDatabase":"PDB data bank","title":"2.4 Angstrom resolution crystal structure of shikimate 5-dehydrogenase (aroE) from Vibrio cholerae O1 biovar eltor str. N16961 in complex with shikimate and NADPH.","authors":["Halavaty A.S.","Light S.H.","Minasov G.","Shuvalova L.","Papazisi L.","Anderson W.F."]}}]}
ChainResidueDetails

244349

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