3PFF
Truncated human atp-citrate lyase with ADP and tartrate bound
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG A 830 |
| Chain | Residue |
| A | ASP257 |
| A | SER260 |
| A | ALA262 |
| A | HOH1104 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 831 |
| Chain | Residue |
| A | ASN203 |
| A | ASP216 |
| A | ADP833 |
| A | HOH1144 |
| A | HOH1168 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE TLA A 832 |
| Chain | Residue |
| A | GLY309 |
| A | ALA310 |
| A | ALA345 |
| A | ASN346 |
| A | PHE347 |
| A | THR348 |
| A | ARG379 |
| A | GLY665 |
| A | HOH998 |
| site_id | AC4 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE ADP A 833 |
| Chain | Residue |
| A | VAL56 |
| A | LYS58 |
| A | ARG65 |
| A | ARG66 |
| A | GLY67 |
| A | PRO109 |
| A | PHE110 |
| A | VAL111 |
| A | HIS113 |
| A | GLU118 |
| A | VAL140 |
| A | ASN203 |
| A | PRO204 |
| A | LEU215 |
| A | ASP216 |
| A | MG831 |
| A | HOH899 |
| A | HOH1139 |
| A | HOH1140 |
| A | HOH1144 |
| A | HOH1155 |
| A | HOH1156 |
| A | HOH1168 |
| A | HOH1189 |
Functional Information from PROSITE/UniProt
| site_id | PS00399 |
| Number of Residues | 17 |
| Details | SUCCINYL_COA_LIG_2 ATP-citrate lyase / succinyl-CoA ligases family active site. GtcAtmfssevQFGHAG |
| Chain | Residue | Details |
| A | GLY746-GLY762 |
| site_id | PS01216 |
| Number of Residues | 30 |
| Details | SUCCINYL_COA_LIG_1 ATP-citrate lyase / succinyl-CoA ligases family signature 1. SRSGGMSnElnniisrttdGvyegVAIGGD |
| Chain | Residue | Details |
| A | SER661-ASP690 |
| site_id | PS01217 |
| Number of Residues | 25 |
| Details | SUCCINYL_COA_LIG_3 ATP-citrate lyase / succinyl-CoA ligases family signature 3. GrIwtMvAGGGASvvysDtIcdl.GG |
| Chain | Residue | Details |
| A | GLY273-GLY297 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Tele-phosphohistidine intermediate => ECO:0000305|PubMed:1371749 |
| Chain | Residue | Details |
| A | HIS760 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 7 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:22102020 |
| Chain | Residue | Details |
| A | LYS58 | |
| A | ARG66 | |
| A | GLY67 | |
| A | PRO109 | |
| A | VAL111 | |
| A | GLU118 | |
| A | ASP216 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:20558738, ECO:0000269|PubMed:22102020 |
| Chain | Residue | Details |
| A | ASP257 | |
| A | SER260 | |
| A | ALA262 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 5 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:20558738 |
| Chain | Residue | Details |
| A | GLY309 | |
| A | ASN346 | |
| A | THR348 | |
| A | TYR364 | |
| A | ARG379 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000255 |
| Chain | Residue | Details |
| A | LEU779 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:15592455 |
| Chain | Residue | Details |
| A | TYR131 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q91V92 |
| Chain | Residue | Details |
| A | SER263 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P16638 |
| Chain | Residue | Details |
| A | THR447 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P16638 |
| Chain | Residue | Details |
| A | SER451 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by PKA and PKB/AKT1 or PKB/AKT2 or BCKDK => ECO:0000269|PubMed:29779826, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | SER455 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER459 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:17924679, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | SER481 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-acetyllysine; alternate => ECO:0000269|PubMed:23932781 |
| Chain | Residue | Details |
| A | LYS540 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine; alternate => ECO:0000269|PubMed:23932781, ECO:0007744|PubMed:19608861 |
| Chain | Residue | Details |
| A | LYS546 | |
| A | LYS554 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:19369195 |
| Chain | Residue | Details |
| A | THR639 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:19369195 |
| Chain | Residue | Details |
| A | SER663 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:15592455, ECO:0007744|PubMed:19369195 |
| Chain | Residue | Details |
| A | TYR682 |
| site_id | SWS_FT_FI18 |
| Number of Residues | 4 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000269|PubMed:27664236, ECO:0000305|PubMed:23932781 |
| Chain | Residue | Details |
| A | LYS540 | |
| A | LYS546 | |
| A | LYS554 |
