3PFD
Crystal structure of an Acyl-CoA dehydrogenase from Mycobacterium thermoresistibile bound to reduced flavin adenine dinucleotide solved by combined iodide ion SAD MR
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003995 | molecular_function | acyl-CoA dehydrogenase activity |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016627 | molecular_function | oxidoreductase activity, acting on the CH-CH group of donors |
| A | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| B | 0003995 | molecular_function | acyl-CoA dehydrogenase activity |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016627 | molecular_function | oxidoreductase activity, acting on the CH-CH group of donors |
| B | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| C | 0003995 | molecular_function | acyl-CoA dehydrogenase activity |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0016627 | molecular_function | oxidoreductase activity, acting on the CH-CH group of donors |
| C | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| D | 0003995 | molecular_function | acyl-CoA dehydrogenase activity |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0016627 | molecular_function | oxidoreductase activity, acting on the CH-CH group of donors |
| D | 0050660 | molecular_function | flavin adenine dinucleotide binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 29 |
| Details | BINDING SITE FOR RESIDUE FDA A 390 |
| Chain | Residue |
| A | TYR132 |
| A | ILE368 |
| A | TYR372 |
| A | THR375 |
| A | GLN377 |
| A | IOD421 |
| A | HOH437 |
| A | HOH451 |
| A | HOH469 |
| B | ARG277 |
| B | GLN279 |
| A | LEU134 |
| B | PHE280 |
| B | VAL284 |
| B | ASN287 |
| B | VAL290 |
| B | GLN346 |
| B | LEU347 |
| B | GLY349 |
| B | GLY350 |
| B | HOH468 |
| D | GLN288 |
| A | SER135 |
| A | GLY140 |
| A | SER141 |
| A | TRP165 |
| A | ILE166 |
| A | THR167 |
| A | LYS210 |
| site_id | AC2 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD A 391 |
| Chain | Residue |
| A | IOD392 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD A 392 |
| Chain | Residue |
| A | ASP75 |
| A | IOD391 |
| site_id | AC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD A 394 |
| Chain | Residue |
| A | ARG23 |
| site_id | AC5 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD A 396 |
| Chain | Residue |
| A | HOH439 |
| site_id | AC6 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD A 398 |
| Chain | Residue |
| A | PHE47 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD A 399 |
| Chain | Residue |
| A | LYS101 |
| A | IOD400 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE IOD A 400 |
| Chain | Residue |
| A | LYS101 |
| A | HIS250 |
| A | IOD399 |
| site_id | AC9 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD A 401 |
| Chain | Residue |
| A | HIS250 |
| site_id | BC1 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD A 405 |
| Chain | Residue |
| A | SER125 |
| site_id | BC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE IOD A 406 |
| Chain | Residue |
| A | ARG137 |
| A | SER162 |
| A | HOH527 |
| site_id | BC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD A 408 |
| Chain | Residue |
| A | ASP156 |
| site_id | BC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD A 409 |
| Chain | Residue |
| A | ARG227 |
| site_id | BC5 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD A 410 |
| Chain | Residue |
| A | THR181 |
| site_id | BC6 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD A 412 |
| Chain | Residue |
| A | GLU236 |
| site_id | BC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE IOD A 413 |
| Chain | Residue |
| A | ASP286 |
| A | GLN291 |
| A | IOD414 |
| site_id | BC8 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD A 414 |
| Chain | Residue |
| A | IOD413 |
| site_id | BC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE IOD A 416 |
| Chain | Residue |
| A | ASP296 |
| D | ARG380 |
| D | HOH431 |
| site_id | CC1 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD A 418 |
| Chain | Residue |
| A | ARG314 |
| site_id | CC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD A 419 |
| Chain | Residue |
| A | GLN377 |
| A | HOH461 |
| site_id | CC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD A 420 |
| Chain | Residue |
| A | GLN377 |
| A | ARG380 |
| site_id | CC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE IOD A 421 |
| Chain | Residue |
| A | GLU373 |
| A | FDA390 |
| A | HOH484 |
| site_id | CC5 |
| Number of Residues | 29 |
| Details | BINDING SITE FOR RESIDUE FDA B 390 |
| Chain | Residue |
| A | ARG277 |
| A | GLN279 |
| A | PHE280 |
| A | VAL284 |
| A | ASN287 |
| A | VAL290 |
| A | GLN346 |
| A | LEU347 |
| A | GLY349 |
| A | GLY350 |
| A | HOH497 |
| B | TYR132 |
| B | LEU134 |
| B | SER135 |
| B | GLY140 |
| B | SER141 |
| B | TRP165 |
| B | THR167 |
| B | LYS210 |
| B | ILE368 |
| B | TYR372 |
| B | THR375 |
| B | GLN377 |
| B | IOD398 |
| B | HOH431 |
| B | HOH456 |
| B | HOH467 |
| B | HOH475 |
| C | GLN288 |
| site_id | CC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD B 392 |
| Chain | Residue |
| B | GLN377 |
| B | ARG380 |
| site_id | CC7 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD B 393 |
| Chain | Residue |
| B | GLN377 |
| site_id | CC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD B 395 |
| Chain | Residue |
| B | ASP296 |
| C | ARG380 |
| site_id | CC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD B 396 |
| Chain | Residue |
| C | HOH491 |
| B | IOD397 |
| site_id | DC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE IOD B 397 |
| Chain | Residue |
| B | SER285 |
| B | ASP286 |
| B | IOD396 |
| site_id | DC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD B 398 |
| Chain | Residue |
| B | GLU373 |
| B | FDA390 |
| site_id | DC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD B 400 |
| Chain | Residue |
| B | ILE20 |
| B | ARG23 |
| site_id | DC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD B 401 |
| Chain | Residue |
| B | HOH527 |
| site_id | DC5 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD B 402 |
| Chain | Residue |
| B | IOD403 |
| site_id | DC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD B 403 |
| Chain | Residue |
| B | ASP75 |
| B | IOD402 |
| site_id | DC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD B 407 |
| Chain | Residue |
| B | GLU40 |
| C | PHE47 |
| site_id | DC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD B 410 |
| Chain | Residue |
| B | LYS101 |
| B | HIS250 |
| site_id | DC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE IOD B 411 |
| Chain | Residue |
| B | LYS101 |
| B | HIS250 |
| B | IOD412 |
| site_id | EC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD B 412 |
| Chain | Residue |
| B | LYS101 |
| B | IOD411 |
| site_id | EC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD B 413 |
| Chain | Residue |
| B | ARG137 |
| B | SER162 |
| site_id | EC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD B 414 |
| Chain | Residue |
| B | THR181 |
| site_id | EC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD B 415 |
| Chain | Residue |
| B | ASP156 |
| site_id | EC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD B 417 |
| Chain | Residue |
| B | ARG314 |
| C | GLU302 |
| site_id | EC6 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD B 418 |
| Chain | Residue |
| B | ARG314 |
| site_id | EC7 |
| Number of Residues | 29 |
| Details | BINDING SITE FOR RESIDUE FDA C 390 |
| Chain | Residue |
| B | GLN288 |
| C | TYR132 |
| C | LEU134 |
| C | SER135 |
| C | GLY140 |
| C | SER141 |
| C | TRP165 |
| C | ILE166 |
| C | THR167 |
| C | LYS210 |
| C | ILE368 |
| C | TYR372 |
| C | THR375 |
| C | GLN377 |
| C | IOD396 |
| C | HOH417 |
| C | HOH428 |
| C | HOH431 |
| D | ARG277 |
| D | GLN279 |
| D | PHE280 |
| D | ARG282 |
| D | VAL284 |
| D | ASN287 |
| D | VAL290 |
| D | GLN346 |
| D | LEU347 |
| D | GLY350 |
| D | HOH430 |
| site_id | EC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD C 391 |
| Chain | Residue |
| B | ARG380 |
| C | ASP296 |
| site_id | EC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD C 392 |
| Chain | Residue |
| C | GLN377 |
| C | ARG380 |
| site_id | FC1 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD C 393 |
| Chain | Residue |
| C | GLN377 |
| site_id | FC2 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD C 395 |
| Chain | Residue |
| C | GLU138 |
| site_id | FC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD C 396 |
| Chain | Residue |
| C | GLU373 |
| C | FDA390 |
| site_id | FC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD C 397 |
| Chain | Residue |
| C | ARG314 |
| C | HOH532 |
| site_id | FC5 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD C 398 |
| Chain | Residue |
| C | ARG23 |
| site_id | FC6 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD C 400 |
| Chain | Residue |
| C | HOH415 |
| site_id | FC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD C 403 |
| Chain | Residue |
| C | GLY281 |
| C | HOH619 |
| site_id | FC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD C 405 |
| Chain | Residue |
| C | LYS101 |
| C | IOD406 |
| site_id | FC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE IOD C 406 |
| Chain | Residue |
| C | LYS101 |
| C | HIS250 |
| C | IOD405 |
| site_id | GC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD C 407 |
| Chain | Residue |
| C | LYS101 |
| C | HIS250 |
| site_id | GC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD C 409 |
| Chain | Residue |
| C | ARG137 |
| C | SER162 |
| site_id | GC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD C 410 |
| Chain | Residue |
| C | THR181 |
| site_id | GC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD C 411 |
| Chain | Residue |
| C | SER285 |
| C | ASP286 |
| site_id | GC5 |
| Number of Residues | 29 |
| Details | BINDING SITE FOR RESIDUE FDA D 390 |
| Chain | Residue |
| A | GLN288 |
| C | ARG277 |
| C | GLN279 |
| C | PHE280 |
| C | ARG282 |
| C | VAL284 |
| C | ASN287 |
| C | VAL290 |
| C | GLN346 |
| C | LEU347 |
| C | GLY350 |
| D | TYR132 |
| D | LEU134 |
| D | SER135 |
| D | GLY140 |
| D | SER141 |
| D | TRP165 |
| D | ILE166 |
| D | THR167 |
| D | LYS210 |
| D | ILE368 |
| D | TYR372 |
| D | THR375 |
| D | GLN377 |
| D | IOD410 |
| D | HOH424 |
| D | HOH438 |
| D | HOH464 |
| D | HOH492 |
| site_id | GC6 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD D 391 |
| Chain | Residue |
| D | ARG385 |
| site_id | GC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD D 393 |
| Chain | Residue |
| D | SER285 |
| D | ASP286 |
| site_id | GC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE IOD D 395 |
| Chain | Residue |
| D | PRO358 |
| D | HOH421 |
| D | HOH602 |
| site_id | GC9 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD D 396 |
| Chain | Residue |
| D | GLN377 |
| site_id | HC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD D 397 |
| Chain | Residue |
| D | GLN377 |
| D | HOH459 |
| site_id | HC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD D 398 |
| Chain | Residue |
| D | ARG314 |
| D | HOH449 |
| site_id | HC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD D 399 |
| Chain | Residue |
| D | ARG23 |
| site_id | HC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD D 401 |
| Chain | Residue |
| A | ARG380 |
| D | ASP296 |
| site_id | HC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE IOD D 402 |
| Chain | Residue |
| C | ARG277 |
| C | LYS278 |
| D | GLU138 |
| site_id | HC6 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD D 403 |
| Chain | Residue |
| D | IOD404 |
| site_id | HC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD D 404 |
| Chain | Residue |
| D | ASP75 |
| D | IOD403 |
| site_id | HC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD D 407 |
| Chain | Residue |
| D | LYS101 |
| D | IOD408 |
| site_id | HC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE IOD D 408 |
| Chain | Residue |
| D | LYS101 |
| D | HIS250 |
| D | IOD407 |
| site_id | IC1 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD D 409 |
| Chain | Residue |
| D | HIS250 |
| site_id | IC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD D 410 |
| Chain | Residue |
| D | GLU373 |
| D | FDA390 |
| site_id | IC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD D 411 |
| Chain | Residue |
| D | TRP174 |
| D | HOH535 |
| site_id | IC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD D 412 |
| Chain | Residue |
| D | ARG137 |
| D | SER162 |
| site_id | IC5 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD D 413 |
| Chain | Residue |
| D | ASP231 |
| site_id | IC6 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD D 414 |
| Chain | Residue |
| D | ASP156 |
| site_id | IC7 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD D 416 |
| Chain | Residue |
| D | THR181 |
| site_id | IC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD D 417 |
| Chain | Residue |
| D | GLY281 |
| D | HOH555 |
Functional Information from PROSITE/UniProt
