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Discovery of Novel Cyanamide-Based Inhibitors of Cathepsin C
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001913 | biological_process | T cell mediated cytotoxicity |
| A | 0004197 | molecular_function | cysteine-type endopeptidase activity |
| A | 0004252 | molecular_function | serine-type endopeptidase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005764 | cellular_component | lysosome |
| A | 0005788 | cellular_component | endoplasmic reticulum lumen |
| A | 0005813 | cellular_component | centrosome |
| A | 0006508 | biological_process | proteolysis |
| A | 0006915 | biological_process | apoptotic process |
| A | 0006955 | biological_process | immune response |
| A | 0008234 | molecular_function | cysteine-type peptidase activity |
| A | 0008239 | molecular_function | dipeptidyl-peptidase activity |
| A | 0010033 | biological_process | obsolete response to organic substance |
| A | 0016020 | cellular_component | membrane |
| A | 0016505 | molecular_function | peptidase activator activity involved in apoptotic process |
| A | 0019902 | molecular_function | phosphatase binding |
| A | 0030134 | cellular_component | COPII-coated ER to Golgi transport vesicle |
| A | 0031404 | molecular_function | chloride ion binding |
| A | 0031642 | biological_process | negative regulation of myelination |
| A | 0033116 | cellular_component | endoplasmic reticulum-Golgi intermediate compartment membrane |
| A | 0035578 | cellular_component | azurophil granule lumen |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0043231 | cellular_component | intracellular membrane-bounded organelle |
| A | 0043621 | molecular_function | obsolete protein self-association |
| A | 0051087 | molecular_function | protein-folding chaperone binding |
| A | 0051603 | biological_process | proteolysis involved in protein catabolic process |
| A | 0062023 | cellular_component | collagen-containing extracellular matrix |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 1903052 | biological_process | positive regulation of proteolysis involved in protein catabolic process |
| A | 1903980 | biological_process | positive regulation of microglial cell activation |
| A | 2001235 | biological_process | positive regulation of apoptotic signaling pathway |
Functional Information from PROSITE/UniProt
| site_id | PS00139 |
| Number of Residues | 12 |
| Details | THIOL_PROTEASE_CYS Eukaryotic thiol (cysteine) proteases cysteine active site. QAsCGSCYSfAS |
| Chain | Residue | Details |
| A | GLN228-SER239 |
| site_id | PS00639 |
| Number of Residues | 11 |
| Details | THIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. TNHAVLLVGYG |
| Chain | Residue | Details |
| A | THR379-GLY389 |
| site_id | PS00640 |
| Number of Residues | 20 |
| Details | THIOL_PROTEASE_ASN Eukaryotic thiol (cysteine) proteases asparagine active site. YWIvKNSWgtgWGenGYFrI |
| Chain | Residue | Details |
| A | TYR398-ILE417 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10088 |
| Chain | Residue | Details |
| A | CYS234 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | ACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10089 |
| Chain | Residue | Details |
| A | HIS381 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | ACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10090 |
| Chain | Residue | Details |
| A | ASN403 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:11726493, ECO:0007744|PDB:1K3B |
| Chain | Residue | Details |
| A | PHE278 | |
| A | TYR280 | |
| A | TYR323 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:11726493, ECO:0000269|PubMed:19167329 |
| Chain | Residue | Details |
| A | ASN5 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19167329 |
| Chain | Residue | Details |
| A | ASN29 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19167329 |
| Chain | Residue | Details |
| A | ASN95 | |
| A | ASN252 |
