3PD6
Crystal structure of mouse mitochondrial aspartate aminotransferase, a newly identified kynurenine aminotransferase-IV
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004069 | molecular_function | L-aspartate:2-oxoglutarate aminotransferase activity |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005743 | cellular_component | mitochondrial inner membrane |
| A | 0005759 | cellular_component | mitochondrial matrix |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006103 | biological_process | 2-oxoglutarate metabolic process |
| A | 0006107 | biological_process | oxaloacetate metabolic process |
| A | 0006520 | biological_process | amino acid metabolic process |
| A | 0006531 | biological_process | aspartate metabolic process |
| A | 0006532 | biological_process | aspartate biosynthetic process |
| A | 0006533 | biological_process | aspartate catabolic process |
| A | 0006536 | biological_process | glutamate metabolic process |
| A | 0006869 | biological_process | lipid transport |
| A | 0008483 | molecular_function | transaminase activity |
| A | 0009058 | biological_process | biosynthetic process |
| A | 0015908 | biological_process | fatty acid transport |
| A | 0016212 | molecular_function | kynurenine-oxoglutarate transaminase activity |
| A | 0019550 | biological_process | glutamate catabolic process to aspartate |
| A | 0019551 | biological_process | obsolete glutamate catabolic process to 2-oxoglutarate |
| A | 0030170 | molecular_function | pyridoxal phosphate binding |
| A | 0043209 | cellular_component | myelin sheath |
| A | 0045471 | biological_process | response to ethanol |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004069 | molecular_function | L-aspartate:2-oxoglutarate aminotransferase activity |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005743 | cellular_component | mitochondrial inner membrane |
| B | 0005759 | cellular_component | mitochondrial matrix |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006103 | biological_process | 2-oxoglutarate metabolic process |
| B | 0006107 | biological_process | oxaloacetate metabolic process |
| B | 0006520 | biological_process | amino acid metabolic process |
| B | 0006531 | biological_process | aspartate metabolic process |
| B | 0006532 | biological_process | aspartate biosynthetic process |
| B | 0006533 | biological_process | aspartate catabolic process |
| B | 0006536 | biological_process | glutamate metabolic process |
| B | 0006869 | biological_process | lipid transport |
| B | 0008483 | molecular_function | transaminase activity |
| B | 0009058 | biological_process | biosynthetic process |
| B | 0015908 | biological_process | fatty acid transport |
| B | 0016212 | molecular_function | kynurenine-oxoglutarate transaminase activity |
| B | 0019550 | biological_process | glutamate catabolic process to aspartate |
| B | 0019551 | biological_process | obsolete glutamate catabolic process to 2-oxoglutarate |
| B | 0030170 | molecular_function | pyridoxal phosphate binding |
| B | 0043209 | cellular_component | myelin sheath |
| B | 0045471 | biological_process | response to ethanol |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0004069 | molecular_function | L-aspartate:2-oxoglutarate aminotransferase activity |
| C | 0005739 | cellular_component | mitochondrion |
| C | 0005743 | cellular_component | mitochondrial inner membrane |
| C | 0005759 | cellular_component | mitochondrial matrix |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0006103 | biological_process | 2-oxoglutarate metabolic process |
| C | 0006107 | biological_process | oxaloacetate metabolic process |
| C | 0006520 | biological_process | amino acid metabolic process |
| C | 0006531 | biological_process | aspartate metabolic process |
| C | 0006532 | biological_process | aspartate biosynthetic process |
| C | 0006533 | biological_process | aspartate catabolic process |
| C | 0006536 | biological_process | glutamate metabolic process |
| C | 0006869 | biological_process | lipid transport |
| C | 0008483 | molecular_function | transaminase activity |
| C | 0009058 | biological_process | biosynthetic process |
| C | 0015908 | biological_process | fatty acid transport |
| C | 0016212 | molecular_function | kynurenine-oxoglutarate transaminase activity |
| C | 0019550 | biological_process | glutamate catabolic process to aspartate |
| C | 0019551 | biological_process | obsolete glutamate catabolic process to 2-oxoglutarate |
| C | 0030170 | molecular_function | pyridoxal phosphate binding |
| C | 0043209 | cellular_component | myelin sheath |
| C | 0045471 | biological_process | response to ethanol |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0004069 | molecular_function | L-aspartate:2-oxoglutarate aminotransferase activity |
| D | 0005739 | cellular_component | mitochondrion |
| D | 0005743 | cellular_component | mitochondrial inner membrane |
| D | 0005759 | cellular_component | mitochondrial matrix |
| D | 0005886 | cellular_component | plasma membrane |
| D | 0006103 | biological_process | 2-oxoglutarate metabolic process |
| D | 0006107 | biological_process | oxaloacetate metabolic process |
| D | 0006520 | biological_process | amino acid metabolic process |
| D | 0006531 | biological_process | aspartate metabolic process |
| D | 0006532 | biological_process | aspartate biosynthetic process |
| D | 0006533 | biological_process | aspartate catabolic process |
| D | 0006536 | biological_process | glutamate metabolic process |
| D | 0006869 | biological_process | lipid transport |
| D | 0008483 | molecular_function | transaminase activity |
| D | 0009058 | biological_process | biosynthetic process |
| D | 0015908 | biological_process | fatty acid transport |
| D | 0016212 | molecular_function | kynurenine-oxoglutarate transaminase activity |
| D | 0019550 | biological_process | glutamate catabolic process to aspartate |
| D | 0019551 | biological_process | obsolete glutamate catabolic process to 2-oxoglutarate |
| D | 0030170 | molecular_function | pyridoxal phosphate binding |
| D | 0043209 | cellular_component | myelin sheath |
| D | 0045471 | biological_process | response to ethanol |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE PMP A 1 |
| Chain | Residue |
| A | SER133 |
| A | ARG287 |
| A | HOH678 |
| A | HOH785 |
| B | KYN1 |
| B | TYR96 |
| A | GLY134 |
| A | THR135 |
| A | TRP162 |
| A | ASN215 |
| A | ASP243 |
| A | TYR246 |
| A | SER276 |
| A | LYS279 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 431 |
| Chain | Residue |
| A | TYR67 |
| A | ASP69 |
| A | TYR75 |
| A | GLU343 |
| A | GLY346 |
| A | HOH571 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 432 |
| Chain | Residue |
| A | ASN370 |
| A | TRP371 |
| A | HIS373 |
| A | THR384 |
| A | HOH563 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 433 |
| Chain | Residue |
| A | GLN204 |
| A | ASN237 |
| B | SER30 |
| B | TRP32 |
| site_id | AC5 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE KYN B 1 |
| Chain | Residue |
| A | PMP1 |
| A | ILE44 |
| A | TRP162 |
| A | PHE381 |
| A | ARG407 |
| B | TYR96 |
| B | ARG313 |
| B | SER317 |
| B | ASN318 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL B 431 |
| Chain | Residue |
| A | ARG313 |
| B | TRP162 |
| B | ASN215 |
| B | PHE381 |
| B | ARG407 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL B 432 |
| Chain | Residue |
| B | TYR67 |
| B | ASP69 |
| B | GLY346 |
| B | MET347 |
| B | HOH701 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL B 433 |
| Chain | Residue |
| A | SER30 |
| A | SER31 |
| A | TRP32 |
| B | GLN204 |
| B | ASN237 |
| site_id | AC9 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE PMP C 1 |
| Chain | Residue |
| C | SER133 |
| C | GLY134 |
| C | THR135 |
| C | TRP162 |
| C | ASN215 |
| C | ASP243 |
| C | TYR246 |
| C | SER276 |
| C | LYS279 |
| C | ARG287 |
| C | GOL433 |
| C | HOH786 |
| C | HOH787 |
| D | TYR96 |
| site_id | BC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL C 431 |
| Chain | Residue |
| C | TYR67 |
| C | ASP69 |
| C | ASP70 |
| C | GLY346 |
| C | MET347 |
| C | ARG350 |
| C | HOH566 |
| site_id | BC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL C 432 |
| Chain | Residue |
| C | LEU157 |
| C | PRO158 |
| C | PRO160 |
| C | SER161 |
| C | TRP162 |
| C | GLY163 |
| C | THR166 |
| C | HOH784 |
| site_id | BC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL C 433 |
| Chain | Residue |
| C | PMP1 |
| C | GLY65 |
| C | TRP162 |
| C | ASN215 |
| C | LYS279 |
| C | PHE381 |
| C | ARG407 |
| D | ARG313 |
| site_id | BC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL C 434 |
| Chain | Residue |
| C | ASN91 |
| D | PRO74 |
| D | VAL76 |
| D | ARG81 |
| site_id | BC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL C 435 |
| Chain | Residue |
| C | SER30 |
| C | SER31 |
| D | GLN204 |
| D | ASN237 |
| site_id | BC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL C 436 |
| Chain | Residue |
| C | HOH805 |
| D | SER31 |
| C | ASN237 |
| site_id | BC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL D 1 |
| Chain | Residue |
| D | TYR67 |
| D | ASP69 |
| D | ASP70 |
| D | TYR75 |
| D | GLY346 |
| D | ARG350 |
Functional Information from PROSITE/UniProt
| site_id | PS00105 |
| Number of Residues | 14 |
| Details | AA_TRANSFER_CLASS_1 Aminotransferases class-I pyridoxal-phosphate attachment site. SYAKnmGLyGERVG |
| Chain | Residue | Details |
| A | SER276-GLY289 | |
| B | SER276-GLY289 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| B | GLY65 | |
| B | TRP162 | |
| D | GLY65 | |
| D | TRP162 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | BINDING: |
| Chain | Residue | Details |
| B | ASN215 | |
| B | ARG407 | |
| D | ASN215 | |
| D | ARG407 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P00505 |
| Chain | Residue | Details |
| B | THR48 | |
| D | THR48 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 14 |
| Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:23576753 |
| Chain | Residue | Details |
| B | LYS59 | |
| D | LYS234 | |
| D | LYS302 | |
| D | LYS345 | |
| D | LYS364 | |
| D | LYS387 | |
| B | LYS82 | |
| B | LYS234 | |
| B | LYS302 | |
| B | LYS345 | |
| B | LYS364 | |
| B | LYS387 | |
| D | LYS59 | |
| D | LYS82 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 24 |
| Details | MOD_RES: N6-succinyllysine; alternate => ECO:0007744|PubMed:23806337 |
| Chain | Residue | Details |
| B | LYS73 | |
| B | LYS363 | |
| B | LYS396 | |
| B | LYS404 | |
| D | LYS73 | |
| D | LYS90 | |
| D | LYS107 | |
| D | LYS122 | |
| D | LYS159 | |
| D | LYS185 | |
| D | LYS296 | |
| B | LYS90 | |
| D | LYS309 | |
| D | LYS338 | |
| D | LYS363 | |
| D | LYS396 | |
| D | LYS404 | |
| B | LYS107 | |
| B | LYS122 | |
| B | LYS159 | |
| B | LYS185 | |
| B | LYS296 | |
| B | LYS309 | |
| B | LYS338 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphotyrosine; alternate => ECO:0000250|UniProtKB:P00505 |
| Chain | Residue | Details |
| B | TYR96 | |
| D | TYR96 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P00505 |
| Chain | Residue | Details |
| B | SER143 | |
| D | SER143 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-succinyllysine => ECO:0007744|PubMed:23806337 |
| Chain | Residue | Details |
| B | LYS227 | |
| D | LYS227 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine; alternate => ECO:0007744|PubMed:23576753 |
| Chain | Residue | Details |
| B | LLP279 | |
| D | LLP279 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | MOD_RES: Asymmetric dimethylarginine => ECO:0007744|PubMed:24129315 |
| Chain | Residue | Details |
| B | ARG313 | |
| D | ARG313 |
