3P9U

Crystal structure of TetX2 from Bacteroides thetaiotaomicron with substrate analogue

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004497	molecular_function	monooxygenase activity
A	0005737	cellular_component	cytoplasm
A	0046677	biological_process	response to antibiotic
A	0071949	molecular_function	FAD binding
B	0000166	molecular_function	nucleotide binding
B	0004497	molecular_function	monooxygenase activity
B	0005737	cellular_component	cytoplasm
B	0046677	biological_process	response to antibiotic
B	0071949	molecular_function	FAD binding
C	0000166	molecular_function	nucleotide binding
C	0004497	molecular_function	monooxygenase activity
C	0005737	cellular_component	cytoplasm
C	0046677	biological_process	response to antibiotic
C	0071949	molecular_function	FAD binding
D	0000166	molecular_function	nucleotide binding
D	0004497	molecular_function	monooxygenase activity
D	0005737	cellular_component	cytoplasm
D	0046677	biological_process	response to antibiotic
D	0071949	molecular_function	FAD binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	25
Details	BINDING SITE FOR RESIDUE FAD A 401

Chain	Residue
A	GLY23
A	ARG121
A	ARG137
A	LYS138
A	LEU139
A	ALA167
A	ASN168
A	GLY169
A	GLN192
A	GLY310
A	ASP311
A	GLY25
A	PRO318
A	GLN322
A	GLY323
A	VAL324
A	HOH403
A	HOH405
A	PRO26
A	VAL27
A	TYR45
A	GLU46
A	ARG47
A	LEU60
A	ARG117

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 1

Chain	Residue
A	HOH8
A	GLY58
A	THR59
A	ARG213
A	ASN226

---

site_id	AC3
Number of Residues	23
Details	BINDING SITE FOR RESIDUE FAD B 401

Chain	Residue
B	SO41
B	ILE22
B	GLY23
B	GLY25
B	PRO26
B	VAL27
B	TYR45
B	GLU46
B	ARG47
B	LEU60
B	ARG117
B	ARG121
B	ARG137
B	LYS138
B	LEU139
B	ASN168
B	GLY169
B	GLN192
B	GLY310
B	ASP311
B	PRO318
B	GLY323
B	VAL324

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 B 1

Chain	Residue
B	GLY58
B	THR59
B	ARG213
B	ASN226
B	HIS234
B	FAD401

---

site_id	AC5
Number of Residues	22
Details	BINDING SITE FOR RESIDUE FAD C 401

Chain	Residue
C	HOH5
C	GLY23
C	GLY25
C	PRO26
C	VAL27
C	TYR45
C	GLU46
C	ARG47
C	LEU60
C	ARG117
C	ARG137
C	LYS138
C	LEU139
C	ALA167
C	ASN168
C	GLY169
C	GLN192
C	GLY310
C	ASP311
C	PRO318
C	GLY323
C	VAL324

---

site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 C 1

Chain	Residue
C	HOH5
C	GLY58
C	THR59
C	ARG213
C	PHE224
C	ASN226
C	HIS234

---

site_id	AC7
Number of Residues	21
Details	BINDING SITE FOR RESIDUE FAD D 401

Chain	Residue
D	ALA167
D	ASN168
D	GLY169
D	GLN192
D	GLY310
D	ASP311
D	PRO318
D	GLN322
D	GLY323
D	VAL324
D	GLY23
D	GLY25
D	PRO26
D	VAL27
D	TYR45
D	GLU46
D	ARG47
D	LEU60
D	ARG117
D	ARG137
D	LEU139

---

site_id	AC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 D 1

Chain	Residue
D	HOH7
D	GLY58
D	THR59
D	ARG213
D	ALA225
D	ASN226
D	HIS234

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	BINDING: BINDING => ECO:0000269|PubMed:21402075, ECO:0000269|PubMed:21590745, ECO:0007744|PDB:2XDO, ECO:0007744|PDB:2XYO, ECO:0007744|PDB:2Y6Q, ECO:0007744|PDB:2Y6R, ECO:0007744|PDB:3P9U, ECO:0007744|PDB:3V3N, ECO:0007744|PDB:3V3O, ECO:0007744|PDB:4A6N, ECO:0007744|PDB:4A99, ECO:0007744|PDB:4GUV

Chain	Residue	Details
A	PRO26
C	TYR45
C	LEU139
C	GLY321
D	PRO26
D	TYR45
D	LEU139
D	GLY321
A	TYR45
A	LEU139
A	GLY321
B	PRO26
B	TYR45
B	LEU139
B	GLY321
C	PRO26

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00845, ECO:0000305|PubMed:21402075

Chain	Residue	Details
A	ARG54
B	ARG54
C	ARG54
D	ARG54

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00845, ECO:0007744|PDB:3V3O

Chain	Residue	Details
A	ASP61
B	ASP61
C	ASP61
D	ASP61

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00845, ECO:0000269|PubMed:21402075, ECO:0000269|PubMed:21590745, ECO:0007744|PDB:2XDO, ECO:0007744|PDB:2XYO, ECO:0007744|PDB:2Y6Q, ECO:0007744|PDB:2Y6R, ECO:0007744|PDB:3P9U, ECO:0007744|PDB:3V3N, ECO:0007744|PDB:3V3O, ECO:0007744|PDB:4A6N, ECO:0007744|PDB:4A99, ECO:0007744|PDB:4GUV

Chain	Residue	Details
A	ARG117
A	ASP311
B	ARG117
B	ASP311
C	ARG117
C	ASP311
D	ARG117
D	ASP311

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:21402075, ECO:0000269|PubMed:23999299, ECO:0007744|PDB:2Y6Q, ECO:0007744|PDB:2Y6R, ECO:0007744|PDB:3V3N, ECO:0007744|PDB:4A99

Chain	Residue	Details
A	GLN192
B	GLN192
C	GLN192
D	GLN192

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:21402075, ECO:0000269|PubMed:23999299, ECO:0007744|PDB:2Y6Q, ECO:0007744|PDB:2Y6R, ECO:0007744|PDB:3V3O, ECO:0007744|PDB:4A6N, ECO:0007744|PDB:4A99

Chain	Residue	Details
A	ARG213
B	ARG213
C	ARG213
D	ARG213

---