3P8N
Crystal structure of HCV NS3/NS4A protease complexed with BI 201335
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006508 | biological_process | proteolysis |
| A | 0008236 | molecular_function | serine-type peptidase activity |
| A | 0019087 | biological_process | transformation of host cell by virus |
| B | 0006508 | biological_process | proteolysis |
| B | 0008236 | molecular_function | serine-type peptidase activity |
| B | 0019087 | biological_process | transformation of host cell by virus |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA A 187 |
| Chain | Residue |
| A | ALA5 |
| A | ALA111 |
| A | HOH189 |
| A | HOH202 |
| A | HOH220 |
| A | HOH236 |
| site_id | AC2 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE L4T A 188 |
| Chain | Residue |
| A | ASP79 |
| A | ASP81 |
| A | ARG123 |
| A | LEU135 |
| A | LYS136 |
| A | GLY137 |
| A | SER139 |
| A | PHE154 |
| A | ARG155 |
| A | ALA156 |
| A | ALA157 |
| A | VAL158 |
| A | CYS159 |
| A | ASP168 |
| A | HOH207 |
| A | HOH211 |
| A | HOH218 |
| A | HOH223 |
| A | HOH230 |
| A | HOH242 |
| A | HOH263 |
| A | TYR56 |
| A | HIS57 |
| A | VAL78 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA B 187 |
| Chain | Residue |
| B | ALA5 |
| B | ALA111 |
| B | HOH190 |
| B | HOH216 |
| B | HOH221 |
| B | HOH223 |
| site_id | AC4 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE L4T B 188 |
| Chain | Residue |
| B | TYR56 |
| B | HIS57 |
| B | VAL78 |
| B | ASP79 |
| B | ASP81 |
| B | ARG123 |
| B | VAL132 |
| B | LEU135 |
| B | LYS136 |
| B | GLY137 |
| B | SER138 |
| B | SER139 |
| B | PHE154 |
| B | ARG155 |
| B | ALA156 |
| B | ALA157 |
| B | VAL158 |
| B | CYS159 |
| B | ASP168 |
| B | HOH203 |
| B | HOH214 |
| B | HOH220 |
| B | HOH241 |
| B | HOH244 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Charge relay system; for serine protease NS3 activity => ECO:0000255|PROSITE-ProRule:PRU01166, ECO:0000305|PubMed:8389908, ECO:0000305|PubMed:8392606, ECO:0000305|PubMed:9060645 |
| Chain | Residue | Details |
| A | HIS57 | |
| B | HIS57 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | ACT_SITE: Charge relay system; for serine protease NS3 activity => ECO:0000255|PROSITE-ProRule:PRU01166, ECO:0000305|PubMed:8389908, ECO:0000305|PubMed:8392606 |
| Chain | Residue | Details |
| A | ASP81 | |
| B | ASP81 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | ACT_SITE: Charge relay system; for serine protease NS3 activity => ECO:0000255|PROSITE-ProRule:PRU01166 |
| Chain | Residue | Details |
| A | SER139 | |
| B | SER139 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01166, ECO:0000269|PubMed:9060645 |
| Chain | Residue | Details |
| A | CYS97 | |
| A | CYS99 | |
| A | CYS145 | |
| A | HIS149 | |
| B | CYS97 | |
| B | CYS99 | |
| B | CYS145 | |
| B | HIS149 |
