3P7X
Crystal structure of an atypical two-cysteine peroxiredoxin (SAOUHSC_01822) from Staphylococcus aureus NCTC8325
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004601 | molecular_function | peroxidase activity |
| A | 0008379 | molecular_function | thioredoxin peroxidase activity |
| A | 0016209 | molecular_function | antioxidant activity |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016684 | molecular_function | oxidoreductase activity, acting on peroxide as acceptor |
| A | 0034599 | biological_process | cellular response to oxidative stress |
| A | 0098869 | biological_process | cellular oxidant detoxification |
| A | 0140824 | molecular_function | thioredoxin-dependent peroxiredoxin activity |
| B | 0004601 | molecular_function | peroxidase activity |
| B | 0008379 | molecular_function | thioredoxin peroxidase activity |
| B | 0016209 | molecular_function | antioxidant activity |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016684 | molecular_function | oxidoreductase activity, acting on peroxide as acceptor |
| B | 0034599 | biological_process | cellular response to oxidative stress |
| B | 0098869 | biological_process | cellular oxidant detoxification |
| B | 0140824 | molecular_function | thioredoxin-dependent peroxiredoxin activity |
| C | 0004601 | molecular_function | peroxidase activity |
| C | 0008379 | molecular_function | thioredoxin peroxidase activity |
| C | 0016209 | molecular_function | antioxidant activity |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0016684 | molecular_function | oxidoreductase activity, acting on peroxide as acceptor |
| C | 0034599 | biological_process | cellular response to oxidative stress |
| C | 0098869 | biological_process | cellular oxidant detoxification |
| C | 0140824 | molecular_function | thioredoxin-dependent peroxiredoxin activity |
| D | 0004601 | molecular_function | peroxidase activity |
| D | 0008379 | molecular_function | thioredoxin peroxidase activity |
| D | 0016209 | molecular_function | antioxidant activity |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0016684 | molecular_function | oxidoreductase activity, acting on peroxide as acceptor |
| D | 0034599 | biological_process | cellular response to oxidative stress |
| D | 0098869 | biological_process | cellular oxidant detoxification |
| D | 0140824 | molecular_function | thioredoxin-dependent peroxiredoxin activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 165 |
| Chain | Residue |
| A | THR2 |
| A | GLU3 |
| A | HIS12 |
| A | LEU13 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PG4 A 166 |
| Chain | Residue |
| A | ILE18 |
| A | PHE23 |
| B | ASP61 |
| B | ARG65 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PG4 A 167 |
| Chain | Residue |
| C | ASP61 |
| C | ARG65 |
| D | ILE18 |
| D | ASP22 |
| D | PHE23 |
| A | GLY8 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PG4 A 168 |
| Chain | Residue |
| A | LYS45 |
| A | LYS73 |
| A | GLU74 |
| A | GLU75 |
| A | ILE77 |
| B | ASP99 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PG4 A 169 |
| Chain | Residue |
| A | ASN35 |
| A | ASP41 |
| A | TYR42 |
| A | HOH210 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE DTV A 170 |
| Chain | Residue |
| A | ARG124 |
| A | HOH287 |
| A | HOH344 |
| C | ARG124 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PG4 B 165 |
| Chain | Residue |
| B | PHE6 |
| B | LYS7 |
| B | PG4167 |
| D | PHE87 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PG4 B 166 |
| Chain | Residue |
| B | LYS7 |
| B | GLY8 |
| D | PHE6 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PG4 B 167 |
| Chain | Residue |
| B | THR57 |
| B | GLY58 |
| B | VAL59 |
| B | CYS60 |
| B | ARG128 |
| B | PG4165 |
| D | ARG91 |
| site_id | BC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 C 165 |
| Chain | Residue |
| C | ALA71 |
| C | SER72 |
| C | LYS73 |
| C | GLU74 |
| C | PG4169 |
| C | HOH190 |
| site_id | BC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PG4 C 166 |
| Chain | Residue |
| C | ALA43 |
| C | GLY44 |
| C | LYS45 |
| C | LYS73 |
| C | GLU74 |
| C | GLU75 |
| C | GLY76 |
| site_id | BC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PG4 C 167 |
| Chain | Residue |
| C | ASN35 |
| C | VAL37 |
| C | ASP41 |
| site_id | BC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PG4 C 168 |
| Chain | Residue |
| C | ASP31 |
| C | ASP33 |
| C | ASP99 |
| C | HOH243 |
| site_id | BC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PG4 C 169 |
| Chain | Residue |
| C | SER69 |
| C | ASP70 |
| C | LYS162 |
| C | SO4165 |
| C | HOH184 |
| D | ASP136 |
| site_id | BC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PG4 C 170 |
| Chain | Residue |
| A | GLY9 |
| C | GLN62 |
| C | LYS66 |
| D | ASP22 |
| site_id | BC7 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PG4 C 171 |
| Chain | Residue |
| A | GLY-1 |
| A | SER0 |
| A | MET1 |
| A | GLY8 |
| C | THR57 |
| C | GLY58 |
| C | VAL59 |
| C | HOH418 |
| site_id | BC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PG4 C 172 |
| Chain | Residue |
| C | GLU20 |
| C | TYR141 |
| C | LYS142 |
| C | ILE144 |
| site_id | BC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PG4 D 165 |
| Chain | Residue |
| B | LYS90 |
| D | ASP56 |
| D | GLY58 |
| D | GLN62 |
| site_id | CC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE DTU D 166 |
| Chain | Residue |
| B | ARG124 |
| D | ARG124 |
Functional Information from PROSITE/UniProt
| site_id | PS01265 |
| Number of Residues | 12 |
| Details | TPX Tpx family signature. SaDLPFAqkRWC |
| Chain | Residue | Details |
| A | SER82-CYS93 |
