3P5T

CFIm25-CFIm68 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003729	molecular_function	mRNA binding
A	0005849	cellular_component	mRNA cleavage factor complex
A	0031124	biological_process	mRNA 3'-end processing
B	0003729	molecular_function	mRNA binding
B	0005849	cellular_component	mRNA cleavage factor complex
B	0031124	biological_process	mRNA 3'-end processing
C	0003729	molecular_function	mRNA binding
C	0005849	cellular_component	mRNA cleavage factor complex
C	0031124	biological_process	mRNA 3'-end processing
D	0003729	molecular_function	mRNA binding
D	0005849	cellular_component	mRNA cleavage factor complex
D	0031124	biological_process	mRNA 3'-end processing
E	0003729	molecular_function	mRNA binding
E	0005849	cellular_component	mRNA cleavage factor complex
E	0031124	biological_process	mRNA 3'-end processing
F	0003729	molecular_function	mRNA binding
F	0005849	cellular_component	mRNA cleavage factor complex
F	0031124	biological_process	mRNA 3'-end processing
L	0003676	molecular_function	nucleic acid binding
L	0003723	molecular_function	RNA binding
M	0003676	molecular_function	nucleic acid binding
M	0003723	molecular_function	RNA binding
N	0003676	molecular_function	nucleic acid binding
N	0003723	molecular_function	RNA binding
O	0003676	molecular_function	nucleic acid binding
O	0003723	molecular_function	RNA binding
P	0003676	molecular_function	nucleic acid binding
P	0003723	molecular_function	RNA binding
Q	0003676	molecular_function	nucleic acid binding
Q	0003723	molecular_function	RNA binding

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	625
Details	Domain: {"description":"Nudix hydrolase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00794","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	395
Details	Region: {"description":"Necessary for interactions with PAPOLA and PABPN1","evidences":[{"source":"PubMed","id":"15169763","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	12
Details	Region: {"description":"Interaction with RNA","evidences":[{"source":"PubMed","id":"20479262","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21295486","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3MDG","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"3MDI","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"3Q2T","evidenceCode":"ECO:0000312"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	126
Details	Motif: {"description":"Nudix box"}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	12
Details	Site: {"description":"Interaction with RNA","evidences":[{"source":"PubMed","id":"20479262","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3MDG","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"3MDI","evidenceCode":"ECO:0000312"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	6
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"15592455","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI7
Number of Residues	6
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI8
Number of Residues	6
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"30916345","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI9
Number of Residues	80
Details	Domain: {"description":"RRM","evidences":[{"source":"PROSITE-ProRule","id":"PRU00176","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	80
Details	Region: {"description":"Necessary for nuclear paraspeckles localization","evidences":[{"source":"PubMed","id":"17267687","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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