Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3P50

Structure of propofol bound to a pentameric ligand-gated ion channel, GLIC

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004888	molecular_function	transmembrane signaling receptor activity
A	0005216	molecular_function	monoatomic ion channel activity
A	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
A	0005267	molecular_function	potassium channel activity
A	0005272	molecular_function	sodium channel activity
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0006813	biological_process	potassium ion transport
A	0006814	biological_process	sodium ion transport
A	0016020	cellular_component	membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0035725	biological_process	sodium ion transmembrane transport
A	0042802	molecular_function	identical protein binding
A	0071805	biological_process	potassium ion transmembrane transport
B	0004888	molecular_function	transmembrane signaling receptor activity
B	0005216	molecular_function	monoatomic ion channel activity
B	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
B	0005267	molecular_function	potassium channel activity
B	0005272	molecular_function	sodium channel activity
B	0005886	cellular_component	plasma membrane
B	0006811	biological_process	monoatomic ion transport
B	0006813	biological_process	potassium ion transport
B	0006814	biological_process	sodium ion transport
B	0016020	cellular_component	membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0035725	biological_process	sodium ion transmembrane transport
B	0042802	molecular_function	identical protein binding
B	0071805	biological_process	potassium ion transmembrane transport
C	0004888	molecular_function	transmembrane signaling receptor activity
C	0005216	molecular_function	monoatomic ion channel activity
C	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
C	0005267	molecular_function	potassium channel activity
C	0005272	molecular_function	sodium channel activity
C	0005886	cellular_component	plasma membrane
C	0006811	biological_process	monoatomic ion transport
C	0006813	biological_process	potassium ion transport
C	0006814	biological_process	sodium ion transport
C	0016020	cellular_component	membrane
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0035725	biological_process	sodium ion transmembrane transport
C	0042802	molecular_function	identical protein binding
C	0071805	biological_process	potassium ion transmembrane transport
D	0004888	molecular_function	transmembrane signaling receptor activity
D	0005216	molecular_function	monoatomic ion channel activity
D	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
D	0005267	molecular_function	potassium channel activity
D	0005272	molecular_function	sodium channel activity
D	0005886	cellular_component	plasma membrane
D	0006811	biological_process	monoatomic ion transport
D	0006813	biological_process	potassium ion transport
D	0006814	biological_process	sodium ion transport
D	0016020	cellular_component	membrane
D	0034220	biological_process	monoatomic ion transmembrane transport
D	0035725	biological_process	sodium ion transmembrane transport
D	0042802	molecular_function	identical protein binding
D	0071805	biological_process	potassium ion transmembrane transport
E	0004888	molecular_function	transmembrane signaling receptor activity
E	0005216	molecular_function	monoatomic ion channel activity
E	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
E	0005267	molecular_function	potassium channel activity
E	0005272	molecular_function	sodium channel activity
E	0005886	cellular_component	plasma membrane
E	0006811	biological_process	monoatomic ion transport
E	0006813	biological_process	potassium ion transport
E	0006814	biological_process	sodium ion transport
E	0016020	cellular_component	membrane
E	0034220	biological_process	monoatomic ion transmembrane transport
E	0035725	biological_process	sodium ion transmembrane transport
E	0042802	molecular_function	identical protein binding
E	0071805	biological_process	potassium ion transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE LMT A 501

Chain	Residue
A	ALA237
A	ILE240
A	LMT502

site_id	AC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE LMT A 502

Chain	Residue
B	LMT501
C	THR226
C	SER230
D	SER230
D	ILE233
E	LMT501
A	THR226
A	SER230
A	ILE233
A	LMT501
B	SER230
B	ILE233

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PFL A 319

Chain	Residue
A	ILE202
A	LEU206
A	TYR254
A	THR255
A	ILE258
A	ASN307
A	PLC320

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PLC A 320

Chain	Residue
A	ARG118
A	PHE121
A	TYR194
A	PFL319

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE LMT B 501

Chain	Residue
A	LMT502
B	ILE233
B	ALA237
B	ILE240

site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PFL B 319

Chain	Residue
B	ILE202
B	LEU206
B	TYR254
B	THR255
B	ILE258
B	ASN307
B	PLC320

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PLC B 320

Chain	Residue
B	ARG118
B	PHE121
B	TYR194
B	PFL319

site_id	AC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PFL C 319

Chain	Residue
C	ILE202
C	LEU206
C	TYR254
C	THR255
C	ILE258
C	ASN307
C	PLC320

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PLC C 320

Chain	Residue
C	ARG118
C	PHE121
C	TYR194
C	PFL319

site_id	BC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE LMT D 501

Chain	Residue
C	ALA237
C	ILE240
D	THR244

site_id	BC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE LMT D 319

Chain	Residue
D	ALA237
D	ILE240
E	THR244

site_id	BC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PFL D 320

Chain	Residue
D	ILE202
D	TYR254
D	THR255
D	ILE258
D	ASN307
D	PLC321

site_id	BC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PLC D 321

Chain	Residue
D	ARG118
D	PHE121
D	TYR194
D	PFL320
D	PLC322

site_id	BC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PLC D 322

Chain	Residue
D	LEU304
D	ALA311
D	PLC321

site_id	BC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE LMT E 501

Chain	Residue
A	THR244
A	LMT502
E	ALA237
E	ILE240

site_id	BC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PFL E 319

Chain	Residue
E	ILE202
E	LEU206
E	TYR254
E	THR255
E	ILE258
E	ASN307
E	PLC320

site_id	BC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PLC E 320

Chain	Residue
E	ARG118
E	PHE121
E	TYR194
E	PHE315
E	PFL319

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	370
Details	Transmembrane: {"description":"Helical"}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	20
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	35
Details	Topological domain: {"description":"Periplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)