3P3E

Crystal Structure of the PSEUDOMONAS AERUGINOSA LpxC/LPC-009 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0005737	cellular_component	cytoplasm
A	0006629	biological_process	lipid metabolic process
A	0009245	biological_process	lipid A biosynthetic process
A	0016020	cellular_component	membrane
A	0016787	molecular_function	hydrolase activity
A	0046872	molecular_function	metal ion binding
A	0103117	molecular_function	UDP-3-O-acyl-N-acetylglucosamine deacetylase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 400

Chain	Residue
A	HIS78
A	HIS237
A	ASP241
A	3P3501

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 401

Chain	Residue
A	HIS162
A	GLU219
A	ASP277
A	ASP279

---

site_id	AC3
Number of Residues	19
Details	BINDING SITE FOR RESIDUE 3P3 A 501

Chain	Residue
A	GLU77
A	HIS78
A	PHE112
A	GLN115
A	THR190
A	PHE191
A	ILE197
A	ARG201
A	GLY209
A	SER210
A	VAL211
A	HIS237
A	ASP241
A	HIS264
A	ZN400
A	NO3709
A	HOH1274
A	HOH1406
A	MET62

---

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NA A 601

Chain	Residue
A	MET194
A	ARG195
A	ASP218

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NO3 A 701

Chain	Residue
A	ILE10
A	ARG12
A	ARG143
A	ARG258
A	PHE260
A	HOH1304

---

site_id	AC6
Number of Residues	9
Details	BINDING SITE FOR RESIDUE NO3 A 702

Chain	Residue
A	ILE158
A	ARG168
A	THR169
A	GLN170
A	ASP232
A	GLU233
A	PHE234
A	VAL235
A	HOH1072

---

site_id	AC7
Number of Residues	8
Details	BINDING SITE FOR RESIDUE NO3 A 703

Chain	Residue
A	ARG189
A	SER202
A	GLN203
A	ASN204
A	ARG229
A	HOH1017
A	HOH1166
A	HOH1261

---

site_id	AC8
Number of Residues	8
Details	BINDING SITE FOR RESIDUE NO3 A 704

Chain	Residue
A	TYR25
A	SER96
A	PRO148
A	PHE149
A	ASP150
A	HOH1015
A	HOH1037
A	HOH1116

---

site_id	AC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NO3 A 705

Chain	Residue
A	SER180
A	HOH1076
A	HOH1390

---

site_id	BC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NO3 A 706

Chain	Residue
A	ILE158
A	ASP159
A	PHE160
A	LYS261
A	HOH1203
A	HOH1303

---

site_id	BC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE NO3 A 707

Chain	Residue
A	THR14
A	TYR25
A	ARG133
A	GLU134
A	PRO148
A	HOH1014
A	HOH1093
A	HOH1140
A	HOH1238

---

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NO3 A 708

Chain	Residue
A	TYR230
A	GLU231
A	ASP232
A	LYS236
A	NO3714

---

site_id	BC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE NO3 A 709

Chain	Residue
A	MET62
A	LYS238
A	GLY263
A	HIS264
A	3P3501
A	NO3716
A	HOH1035

---

site_id	BC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE NO3 A 710

Chain	Residue
A	VAL137
A	GLU138
A	GLN269
A	HOH1050
A	HOH1106
A	HOH1218
A	HOH1348
A	HOH1379

---

site_id	BC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NO3 A 711

Chain	Residue
A	THR14
A	GLY15
A	VAL16
A	LYS23
A	HOH1356

---

site_id	BC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NO3 A 712

Chain	Residue
A	SER173
A	VAL174
A	THR179
A	LYS236
A	HOH1107
A	HOH1411

---

site_id	BC8
Number of Residues	10
Details	BINDING SITE FOR RESIDUE NO3 A 713

Chain	Residue
A	LYS8
A	ASN9
A	ALA117
A	GLY118
A	LEU223
A	GLU225
A	HOH1019
A	HOH1152
A	HOH1281
A	HOH1375

---

site_id	BC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NO3 A 714

Chain	Residue
A	GLU184
A	TYR230
A	NO3708
A	HOH1052
A	HOH1378

---

site_id	CC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NO3 A 715

Chain	Residue
A	PRO30
A	HOH1158
A	HOH1180
A	HOH1271

---

site_id	CC2
Number of Residues	10
Details	BINDING SITE FOR RESIDUE NO3 A 716

Chain	Residue
A	THR60
A	THR61
A	MET62
A	SER63
A	GLY263
A	HIS264
A	ALA265
A	NO3709
A	NO3717
A	HOH1318

---

site_id	CC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE NO3 A 717

Chain	Residue
A	GLU139
A	LYS142
A	GLY263
A	ALA265
A	LEU266
A	NO3716
A	HOH1144
A	HOH1360

---

site_id	CC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NO3 A 718

Chain	Residue
A	HIS19
A	LEU200
A	LEU205
A	ALA206
A	HOH1308

---

site_id	CC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NO3 A 719

Chain	Residue
A	ILE2
A	TYR296
A	MET297
A	HOH1089

---

site_id	CC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NO3 A 720

Chain	Residue
A	ARG166
A	GLN269
A	ARG272
A	HOH1122
A	HOH1188
A	HOH1221

---

site_id	CC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NO3 A 721

Chain	Residue
A	ARG41
A	ASP70
A	VAL71
A	LYS72
A	HOH1299
A	HOH1332

---

site_id	CC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NO3 A 722

Chain	Residue
A	LYS23
A	LYS132
A	ARG133
A	HOH1197
A	HOH1222

---

site_id	CC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NO3 A 723

Chain	Residue
A	SER136
A	VAL137
A	ARG143
A	ARG221
A	HOH1050

---

site_id	DC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE NO3 A 724

Chain	Residue
A	PHE152
A	PHE176
A	SER177
A	PRO293
A	ILE294
A	SER295
A	HOH1045
A	HOH1090
A	HOH1161
A	HOH1309

---

site_id	DC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE NO3 A 725

Chain	Residue
A	MET103
A	ASP104
A	PRO109
A	GLU198
A	HOH1131
A	HOH1157
A	HOH1301
A	HOH1386

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Proton donor","evidences":[{"source":"HAMAP-Rule","id":"MF_00388","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00388","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---