Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3P1M

Crystal structure of human ferredoxin-1 (FDX1) in complex with iron-sulfur cluster

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0051536	molecular_function	iron-sulfur cluster binding
A	0051537	molecular_function	2 iron, 2 sulfur cluster binding
A	0140647	biological_process	P450-containing electron transport chain
B	0051536	molecular_function	iron-sulfur cluster binding
B	0051537	molecular_function	2 iron, 2 sulfur cluster binding
B	0140647	biological_process	P450-containing electron transport chain
C	0051536	molecular_function	iron-sulfur cluster binding
C	0051537	molecular_function	2 iron, 2 sulfur cluster binding
C	0140647	biological_process	P450-containing electron transport chain
D	0051536	molecular_function	iron-sulfur cluster binding
D	0051537	molecular_function	2 iron, 2 sulfur cluster binding
D	0140647	biological_process	P450-containing electron transport chain
E	0051536	molecular_function	iron-sulfur cluster binding
E	0051537	molecular_function	2 iron, 2 sulfur cluster binding
E	0140647	biological_process	P450-containing electron transport chain
F	0051536	molecular_function	iron-sulfur cluster binding
F	0051537	molecular_function	2 iron, 2 sulfur cluster binding
F	0140647	biological_process	P450-containing electron transport chain
G	0051536	molecular_function	iron-sulfur cluster binding
G	0051537	molecular_function	2 iron, 2 sulfur cluster binding
G	0140647	biological_process	P450-containing electron transport chain
H	0051536	molecular_function	iron-sulfur cluster binding
H	0051537	molecular_function	2 iron, 2 sulfur cluster binding
H	0140647	biological_process	P450-containing electron transport chain

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE FES A 2

Chain	Residue
A	GLY104
A	CYS106
A	GLY108
A	LEU110
A	ALA111
A	CYS112
A	CYS115
A	CYS152

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE FLC A 6

Chain	Residue
A	ARG175
A	ASP179
A	K192
G	TYR142
G	GLY143
G	LEU144
A	VAL171

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE K A 192

Chain	Residue
A	FLC6
A	SER177
A	ASP179

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FES B 3

Chain	Residue
B	CYS106
B	GLY108
B	CYS112
B	CYS115
B	CYS152

site_id	AC5
Number of Residues	9
Details	BINDING SITE FOR RESIDUE FLC B 192

Chain	Residue
B	TYR142
B	GLY143
B	LEU144
B	K193
B	HOH201
H	TYR142
H	VAL171
H	ARG175
H	ASP179

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE K B 193

Chain	Residue
B	FLC192
B	HOH201
H	SER177
H	ASP179

site_id	AC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE FES C 4

Chain	Residue
C	GLY104
C	CYS106
C	GLY108
C	LEU110
C	CYS112
C	CYS115
C	CYS152

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE FLC C 5

Chain	Residue
C	ARG175
C	ASP179
C	K192
C	HOH203
F	GLY143
F	LEU144

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE FLC C 8

Chain	Residue
C	GLY143
F	K8
F	TYR142
F	VAL171
F	ARG175
F	ASP179

site_id	BC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE K C 192

Chain	Residue
C	FLC5
C	SER177
C	ASP179

site_id	BC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE FES D 5

Chain	Residue
D	CYS106
D	GLY108
D	LEU110
D	ALA111
D	CYS112
D	CYS115
D	CYS152

site_id	BC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE FLC D 2

Chain	Residue
D	VAL171
D	ARG175
D	ASP179
D	K192
D	HOH205
E	TYR142
E	GLY143
E	LEU144

site_id	BC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE FLC D 9

Chain	Residue
D	LEU79
D	THR80
D	HOH200

site_id	BC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE K D 192

Chain	Residue
D	FLC2
D	SER177
D	ASP179
D	HOH205

site_id	BC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FES E 6

Chain	Residue
E	CYS106
E	GLY108
E	CYS112
E	CYS115
E	CYS152

site_id	BC7
Number of Residues	9
Details	BINDING SITE FOR RESIDUE FLC E 4

Chain	Residue
D	ALA141
D	TYR142
D	GLY143
D	LEU144
E	VAL171
E	ALA174
E	ARG175
E	K192
E	HOH202

site_id	BC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE K E 192

Chain	Residue
E	FLC4
E	SER177
E	ASP179

site_id	BC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE FES F 7

Chain	Residue
F	GLY108
F	CYS112
F	CYS115
F	CYS152
F	GLY104
F	CYS106

site_id	CC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE K F 8

Chain	Residue
C	FLC8
C	HOH222
F	SER177
F	ASP179

site_id	CC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL F 1

Chain	Residue
C	LEU140
C	HOH265
C	HOH266
F	LEU140
F	VAL171
F	HOH216

site_id	CC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE FES G 1

Chain	Residue
G	GLY104
G	CYS106
G	GLY108
G	CYS112
G	CYS115
G	CYS152

site_id	CC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE FLC G 192

Chain	Residue
A	GLY143
G	TYR142
G	VAL171
G	ARG175
G	ASP179
G	K193

site_id	CC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE K G 193

Chain	Residue
A	HOH197
G	SER177
G	ASP179
G	FLC192

site_id	CC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL G 194

Chain	Residue
A	LEU140
G	LEU140
G	VAL171
G	HOH207

site_id	CC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE FES H 8

Chain	Residue
H	CYS106
H	GLY108
H	LEU110
H	CYS112
H	CYS115
H	CYS152

site_id	CC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE FLC H 7

Chain	Residue
B	VAL171
B	ARG175
H	TYR142
H	GLY143
H	LEU144
H	K192

site_id	CC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE K H 192

Chain	Residue
B	SER177
B	ASP179
H	FLC7

Functional Information from PROSITE/UniProt

site_id	PS00814
Number of Residues	11
Details	ADX Adrenodoxin family, iron-sulfur binding region signature. CegTlACSTCH

Chain	Residue	Details
A	CYS106-HIS116

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	32
Details	BINDING:

Chain	Residue	Details
A	CYS106
C	CYS112
C	CYS115
C	CYS152
D	CYS106
D	CYS112
D	CYS115
D	CYS152
E	CYS106
E	CYS112
E	CYS115
A	CYS112
E	CYS152
F	CYS106
F	CYS112
F	CYS115
F	CYS152
G	CYS106
G	CYS112
G	CYS115
G	CYS152
H	CYS106
A	CYS115
H	CYS112
H	CYS115
H	CYS152
A	CYS152
B	CYS106
B	CYS112
B	CYS115
B	CYS152
C	CYS106

site_id	SWS_FT_FI2
Number of Residues	8
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P46656

Chain	Residue	Details
A	SER63
B	SER63
C	SER63
D	SER63
E	SER63
F	SER63
G	SER63
H	SER63

site_id	SWS_FT_FI3
Number of Residues	8
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250\|UniProtKB:P46656

Chain	Residue	Details
A	LYS66
B	LYS66
C	LYS66
D	LYS66
E	LYS66
F	LYS66
G	LYS66
H	LYS66

site_id	SWS_FT_FI4
Number of Residues	8
Details	MOD_RES: N6-succinyllysine => ECO:0000250\|UniProtKB:P46656

Chain	Residue	Details
A	LYS158
B	LYS158
C	LYS158
D	LYS158
E	LYS158
F	LYS158
G	LYS158
H	LYS158

site_id	SWS_FT_FI5
Number of Residues	8
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:23186163

Chain	Residue	Details
A	SER177
B	SER177
C	SER177
D	SER177
E	SER177
F	SER177
G	SER177
H	SER177

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)