Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004451 | molecular_function | isocitrate lyase activity |
| A | 0006097 | biological_process | glyoxylate cycle |
| A | 0006099 | biological_process | tricarboxylic acid cycle |
| A | 0016829 | molecular_function | lyase activity |
| A | 0019752 | biological_process | carboxylic acid metabolic process |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004451 | molecular_function | isocitrate lyase activity |
| B | 0006097 | biological_process | glyoxylate cycle |
| B | 0006099 | biological_process | tricarboxylic acid cycle |
| B | 0016829 | molecular_function | lyase activity |
| B | 0019752 | biological_process | carboxylic acid metabolic process |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0004451 | molecular_function | isocitrate lyase activity |
| C | 0006097 | biological_process | glyoxylate cycle |
| C | 0006099 | biological_process | tricarboxylic acid cycle |
| C | 0016829 | molecular_function | lyase activity |
| C | 0019752 | biological_process | carboxylic acid metabolic process |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0004451 | molecular_function | isocitrate lyase activity |
| D | 0006097 | biological_process | glyoxylate cycle |
| D | 0006099 | biological_process | tricarboxylic acid cycle |
| D | 0016829 | molecular_function | lyase activity |
| D | 0019752 | biological_process | carboxylic acid metabolic process |
| D | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 440 |
| Chain | Residue |
| A | ALA92 |
| A | HOH562 |
| B | ARG116 |
| B | HOH530 |
| B | HOH666 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 445 |
| Chain | Residue |
| A | HOH475 |
| A | CYS275 |
| A | ASP276 |
| A | LYS304 |
| A | LEU305 |
| site_id | AC3 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE ICT A 450 |
| Chain | Residue |
| A | SER84 |
| A | GLY85 |
| A | TRP86 |
| A | ASP147 |
| A | CYS185 |
| A | GLY186 |
| A | HIS187 |
| A | ARG222 |
| A | GLU281 |
| A | ASN309 |
| A | SER311 |
| A | SER313 |
| A | THR343 |
| A | LEU344 |
| A | MG430 |
| A | HOH585 |
| A | HOH586 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 430 |
| Chain | Residue |
| A | ASP147 |
| A | ICT450 |
| A | HOH584 |
| A | HOH585 |
| A | HOH586 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO B 445 |
| Chain | Residue |
| B | ILE19 |
| B | ASP276 |
| B | LYS304 |
| B | LEU305 |
| B | HOH516 |
| site_id | AC6 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE ICT B 450 |
| Chain | Residue |
| B | TYR82 |
| B | SER84 |
| B | GLY85 |
| B | TRP86 |
| B | ASP147 |
| B | CYS185 |
| B | GLY186 |
| B | HIS187 |
| B | ARG222 |
| B | GLU281 |
| B | ASN309 |
| B | SER311 |
| B | SER313 |
| B | THR343 |
| B | MG430 |
| B | HOH486 |
| B | HOH535 |
| B | HOH536 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG B 430 |
| Chain | Residue |
| B | ASP147 |
| B | ICT450 |
| B | HOH486 |
| B | HOH535 |
| B | HOH536 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO C 445 |
| Chain | Residue |
| C | ILE19 |
| C | CYS275 |
| C | ASP276 |
| C | LYS304 |
| C | LEU305 |
| C | HOH556 |
| site_id | AC9 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE ICT C 450 |
| Chain | Residue |
| C | SER84 |
| C | GLY85 |
| C | TRP86 |
| C | ASP147 |
| C | CYS185 |
| C | GLY186 |
| C | HIS187 |
| C | ARG222 |
| C | GLU281 |
| C | ASN309 |
| C | SER311 |
| C | SER313 |
| C | THR343 |
| C | MG430 |
| C | HOH517 |
| C | HOH570 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG C 430 |
| Chain | Residue |
| C | ASP147 |
| C | ICT450 |
| C | HOH517 |
| C | HOH518 |
| C | HOH570 |
| site_id | BC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO C 440 |
| Chain | Residue |
| C | ARG116 |
| C | HOH612 |
| C | HOH664 |
| D | ARG116 |
| D | HOH484 |
| site_id | BC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO D 445 |
| Chain | Residue |
| D | ASP276 |
| D | LYS304 |
| D | LEU305 |
| D | HOH555 |
| site_id | BC4 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE ICT D 450 |
| Chain | Residue |
| D | TRP86 |
| D | ASP147 |
| D | CYS185 |
| D | GLY186 |
| D | HIS187 |
| D | ARG222 |
| D | GLU281 |
| D | ASN309 |
| D | SER311 |
| D | SER313 |
| D | THR343 |
| D | LEU344 |
| D | MG430 |
| D | HOH551 |
| D | HOH553 |
| D | TYR82 |
| D | SER84 |
| D | GLY85 |
| site_id | BC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG D 430 |
| Chain | Residue |
| D | ASP147 |
| D | ICT450 |
| D | HOH485 |
| D | HOH551 |
| D | HOH553 |
Functional Information from PROSITE/UniProt
| site_id | PS00161 |
| Number of Residues | 6 |
| Details | ISOCITRATE_LYASE Isocitrate lyase signature. KKCGHL |
| Chain | Residue | Details |
| A | LYS183-LEU188 | |
