3P0E

Structure of hUPP2 in an active conformation with bound 5-benzylacyclouridine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004850	molecular_function	uridine phosphorylase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006218	biological_process	uridine catabolic process
A	0006248	biological_process	CMP catabolic process
A	0006249	biological_process	dCMP catabolic process
A	0009032	molecular_function	thymidine phosphorylase activity
A	0009116	biological_process	nucleoside metabolic process
A	0009166	biological_process	nucleotide catabolic process
A	0016154	molecular_function	pyrimidine-nucleoside phosphorylase activity
A	0016740	molecular_function	transferase activity
A	0016757	molecular_function	glycosyltransferase activity
A	0016763	molecular_function	pentosyltransferase activity
A	0042178	biological_process	xenobiotic catabolic process
A	0042802	molecular_function	identical protein binding
A	0044206	biological_process	UMP salvage
A	0045098	cellular_component	type III intermediate filament
A	0046050	biological_process	UMP catabolic process
A	0046074	biological_process	dTMP catabolic process
A	0046079	biological_process	dUMP catabolic process
A	0046108	biological_process	uridine metabolic process
A	0047847	molecular_function	deoxyuridine phosphorylase activity
B	0003824	molecular_function	catalytic activity
B	0004850	molecular_function	uridine phosphorylase activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006218	biological_process	uridine catabolic process
B	0006248	biological_process	CMP catabolic process
B	0006249	biological_process	dCMP catabolic process
B	0009032	molecular_function	thymidine phosphorylase activity
B	0009116	biological_process	nucleoside metabolic process
B	0009166	biological_process	nucleotide catabolic process
B	0016154	molecular_function	pyrimidine-nucleoside phosphorylase activity
B	0016740	molecular_function	transferase activity
B	0016757	molecular_function	glycosyltransferase activity
B	0016763	molecular_function	pentosyltransferase activity
B	0042178	biological_process	xenobiotic catabolic process
B	0042802	molecular_function	identical protein binding
B	0044206	biological_process	UMP salvage
B	0045098	cellular_component	type III intermediate filament
B	0046050	biological_process	UMP catabolic process
B	0046074	biological_process	dTMP catabolic process
B	0046079	biological_process	dUMP catabolic process
B	0046108	biological_process	uridine metabolic process
B	0047847	molecular_function	deoxyuridine phosphorylase activity
C	0003824	molecular_function	catalytic activity
C	0004850	molecular_function	uridine phosphorylase activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006218	biological_process	uridine catabolic process
C	0006248	biological_process	CMP catabolic process
C	0006249	biological_process	dCMP catabolic process
C	0009032	molecular_function	thymidine phosphorylase activity
C	0009116	biological_process	nucleoside metabolic process
C	0009166	biological_process	nucleotide catabolic process
C	0016154	molecular_function	pyrimidine-nucleoside phosphorylase activity
C	0016740	molecular_function	transferase activity
C	0016757	molecular_function	glycosyltransferase activity
C	0016763	molecular_function	pentosyltransferase activity
C	0042178	biological_process	xenobiotic catabolic process
C	0042802	molecular_function	identical protein binding
C	0044206	biological_process	UMP salvage
C	0045098	cellular_component	type III intermediate filament
C	0046050	biological_process	UMP catabolic process
C	0046074	biological_process	dTMP catabolic process
C	0046079	biological_process	dUMP catabolic process
C	0046108	biological_process	uridine metabolic process
C	0047847	molecular_function	deoxyuridine phosphorylase activity
D	0003824	molecular_function	catalytic activity
D	0004850	molecular_function	uridine phosphorylase activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006218	biological_process	uridine catabolic process
D	0006248	biological_process	CMP catabolic process
D	0006249	biological_process	dCMP catabolic process
D	0009032	molecular_function	thymidine phosphorylase activity
D	0009116	biological_process	nucleoside metabolic process
D	0009166	biological_process	nucleotide catabolic process
D	0016154	molecular_function	pyrimidine-nucleoside phosphorylase activity
D	0016740	molecular_function	transferase activity
D	0016757	molecular_function	glycosyltransferase activity
D	0016763	molecular_function	pentosyltransferase activity
D	0042178	biological_process	xenobiotic catabolic process
D	0042802	molecular_function	identical protein binding
D	0044206	biological_process	UMP salvage
D	0045098	cellular_component	type III intermediate filament
D	0046050	biological_process	UMP catabolic process
D	0046074	biological_process	dTMP catabolic process
D	0046079	biological_process	dUMP catabolic process
D	0046108	biological_process	uridine metabolic process
D	0047847	molecular_function	deoxyuridine phosphorylase activity
E	0003824	molecular_function	catalytic activity
E	0004850	molecular_function	uridine phosphorylase activity
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006218	biological_process	uridine catabolic process
E	0006248	biological_process	CMP catabolic process
E	0006249	biological_process	dCMP catabolic process
E	0009032	molecular_function	thymidine phosphorylase activity
E	0009116	biological_process	nucleoside metabolic process
E	0009166	biological_process	nucleotide catabolic process
E	0016154	molecular_function	pyrimidine-nucleoside phosphorylase activity
E	0016740	molecular_function	transferase activity
E	0016757	molecular_function	glycosyltransferase activity
E	0016763	molecular_function	pentosyltransferase activity
E	0042178	biological_process	xenobiotic catabolic process
E	0042802	molecular_function	identical protein binding
E	0044206	biological_process	UMP salvage
E	0045098	cellular_component	type III intermediate filament
E	0046050	biological_process	UMP catabolic process
E	0046074	biological_process	dTMP catabolic process
E	0046079	biological_process	dUMP catabolic process
E	0046108	biological_process	uridine metabolic process
E	0047847	molecular_function	deoxyuridine phosphorylase activity
F	0003824	molecular_function	catalytic activity
F	0004850	molecular_function	uridine phosphorylase activity
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006218	biological_process	uridine catabolic process
F	0006248	biological_process	CMP catabolic process
F	0006249	biological_process	dCMP catabolic process
F	0009032	molecular_function	thymidine phosphorylase activity
F	0009116	biological_process	nucleoside metabolic process
F	0009166	biological_process	nucleotide catabolic process
F	0016154	molecular_function	pyrimidine-nucleoside phosphorylase activity
F	0016740	molecular_function	transferase activity
F	0016757	molecular_function	glycosyltransferase activity
F	0016763	molecular_function	pentosyltransferase activity
F	0042178	biological_process	xenobiotic catabolic process
F	0042802	molecular_function	identical protein binding
F	0044206	biological_process	UMP salvage
F	0045098	cellular_component	type III intermediate filament
F	0046050	biological_process	UMP catabolic process
F	0046074	biological_process	dTMP catabolic process
F	0046079	biological_process	dUMP catabolic process
F	0046108	biological_process	uridine metabolic process
F	0047847	molecular_function	deoxyuridine phosphorylase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	BINDING SITE FOR RESIDUE BAU A 400

Chain	Residue
A	MET116
A	MET255
A	HOH319
A	HOH346
A	PO4401
B	TYR41
B	HIS42
A	THR147
A	SER148
A	GLY149
A	PHE219
A	GLN223
A	ARG225
A	ILE253
A	GLU254

---

site_id	AC2
Number of Residues	10
Details	BINDING SITE FOR RESIDUE PO4 A 401

Chain	Residue
A	GLY66
A	ARG70
A	ARG144
A	ILE145
A	GLY146
A	THR147
A	HOH319
A	HOH366
A	BAU400
B	ARG100

---

site_id	AC3
Number of Residues	12
Details	BINDING SITE FOR RESIDUE BAU B 400

Chain	Residue
A	HIS42
B	THR147
B	SER148
B	GLY149
B	PHE219
B	GLN223
B	ARG225
B	ILE253
B	GLU254
B	MET255
B	ILE287
B	PO4401

---

site_id	AC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PO4 B 401

Chain	Residue
A	ARG100
B	GLY66
B	ARG70
B	ARG144
B	ILE145
B	GLY146
B	THR147
B	BAU400

---

site_id	AC5
Number of Residues	18
Details	BINDING SITE FOR RESIDUE BAU C 400

Chain	Residue
C	MET116
C	THR147
C	SER148
C	GLY149
C	PHE219
C	GLN223
C	ARG225
C	ILE253
C	GLU254
C	MET255
C	LEU279
C	ASP285
C	HOH332
C	HOH341
C	PO4401
D	TYR41
D	HIS42
D	ARG100

---

site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PO4 C 401

Chain	Residue
C	GLY66
C	ARG144
C	GLY146
C	THR147
C	HOH332
C	BAU400
D	ARG100

---

site_id	AC7
Number of Residues	16
Details	BINDING SITE FOR RESIDUE BAU D 400

Chain	Residue
C	TYR41
C	HIS42
D	MET116
D	THR147
D	SER148
D	GLY149
D	PHE219
D	GLN223
D	ARG225
D	ILE253
D	GLU254
D	ASP285
D	ILE287
D	HOH329
D	HOH350
D	PO4401

---

site_id	AC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PO4 D 401

Chain	Residue
C	ARG100
D	GLY66
D	ARG144
D	GLY146
D	THR147
D	HOH329
D	BAU400

---

site_id	AC9
Number of Residues	14
Details	BINDING SITE FOR RESIDUE BAU E 400

Chain	Residue
E	ARG225
E	ILE253
E	GLU254
E	MET255
E	HOH335
E	PO4401
F	TYR41
F	HIS42
E	MET116
E	THR147
E	SER148
E	GLY149
E	PHE219
E	GLN223

---

site_id	BC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PO4 E 401

Chain	Residue
E	GLY66
E	ARG144
E	ILE145
E	GLY146
E	THR147
E	BAU400
F	ARG100

---

site_id	BC2
Number of Residues	15
Details	BINDING SITE FOR RESIDUE BAU F 400

Chain	Residue
E	TYR41
E	HIS42
F	MET116
F	THR147
F	SER148
F	GLY149
F	PHE219
F	GLN223
F	ARG225
F	ILE253
F	GLU254
F	MET255
F	LEU279
F	HOH335
F	PO4401

---

site_id	BC3
Number of Residues	10
Details	BINDING SITE FOR RESIDUE PO4 F 401

Chain	Residue
E	ARG100
F	GLY66
F	ARG70
F	ARG144
F	ILE145
F	GLY146
F	THR147
F	HOH321
F	HOH350
F	BAU400

---

Functional Information from PROSITE/UniProt

site_id	PS01232
Number of Residues	16
Details	PNP_UDP_1 Purine and other phosphorylases family 1 signature. ShGMGiPSiSImlhEL

Chain	Residue	Details
A	SER113-LEU128

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	30
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21855639","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3P0E","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	18
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21855639","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2XRF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3P0E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3P0F","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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