3OZE
Crystal Structure of human 5'-deoxy-5'-methyladenosine phosphorylase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004645 | molecular_function | 1,4-alpha-oligoglucan phosphorylase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006139 | biological_process | nucleobase-containing compound metabolic process |
| A | 0006738 | biological_process | nicotinamide riboside catabolic process |
| A | 0009116 | biological_process | nucleoside metabolic process |
| A | 0016763 | molecular_function | pentosyltransferase activity |
| A | 0017061 | molecular_function | S-methyl-5-thioadenosine phosphorylase activity |
| A | 0033353 | biological_process | L-methionine cycle |
| A | 0070062 | cellular_component | extracellular exosome |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004645 | molecular_function | 1,4-alpha-oligoglucan phosphorylase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006139 | biological_process | nucleobase-containing compound metabolic process |
| B | 0006738 | biological_process | nicotinamide riboside catabolic process |
| B | 0009116 | biological_process | nucleoside metabolic process |
| B | 0016763 | molecular_function | pentosyltransferase activity |
| B | 0017061 | molecular_function | S-methyl-5-thioadenosine phosphorylase activity |
| B | 0033353 | biological_process | L-methionine cycle |
| B | 0070062 | cellular_component | extracellular exosome |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0004645 | molecular_function | 1,4-alpha-oligoglucan phosphorylase activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005634 | cellular_component | nucleus |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006139 | biological_process | nucleobase-containing compound metabolic process |
| C | 0006738 | biological_process | nicotinamide riboside catabolic process |
| C | 0009116 | biological_process | nucleoside metabolic process |
| C | 0016763 | molecular_function | pentosyltransferase activity |
| C | 0017061 | molecular_function | S-methyl-5-thioadenosine phosphorylase activity |
| C | 0033353 | biological_process | L-methionine cycle |
| C | 0070062 | cellular_component | extracellular exosome |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0004645 | molecular_function | 1,4-alpha-oligoglucan phosphorylase activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0005634 | cellular_component | nucleus |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0006139 | biological_process | nucleobase-containing compound metabolic process |
| D | 0006738 | biological_process | nicotinamide riboside catabolic process |
| D | 0009116 | biological_process | nucleoside metabolic process |
| D | 0016763 | molecular_function | pentosyltransferase activity |
| D | 0017061 | molecular_function | S-methyl-5-thioadenosine phosphorylase activity |
| D | 0033353 | biological_process | L-methionine cycle |
| D | 0070062 | cellular_component | extracellular exosome |
| E | 0003824 | molecular_function | catalytic activity |
| E | 0004645 | molecular_function | 1,4-alpha-oligoglucan phosphorylase activity |
| E | 0005515 | molecular_function | protein binding |
| E | 0005634 | cellular_component | nucleus |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0005829 | cellular_component | cytosol |
| E | 0006139 | biological_process | nucleobase-containing compound metabolic process |
| E | 0006738 | biological_process | nicotinamide riboside catabolic process |
| E | 0009116 | biological_process | nucleoside metabolic process |
| E | 0016763 | molecular_function | pentosyltransferase activity |
| E | 0017061 | molecular_function | S-methyl-5-thioadenosine phosphorylase activity |
| E | 0033353 | biological_process | L-methionine cycle |
| E | 0070062 | cellular_component | extracellular exosome |
| F | 0003824 | molecular_function | catalytic activity |
| F | 0004645 | molecular_function | 1,4-alpha-oligoglucan phosphorylase activity |
| F | 0005515 | molecular_function | protein binding |
| F | 0005634 | cellular_component | nucleus |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0005829 | cellular_component | cytosol |
| F | 0006139 | biological_process | nucleobase-containing compound metabolic process |
| F | 0006738 | biological_process | nicotinamide riboside catabolic process |
| F | 0009116 | biological_process | nucleoside metabolic process |
| F | 0016763 | molecular_function | pentosyltransferase activity |
| F | 0017061 | molecular_function | S-methyl-5-thioadenosine phosphorylase activity |
| F | 0033353 | biological_process | L-methionine cycle |
| F | 0070062 | cellular_component | extracellular exosome |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE PO4 A 284 |
| Chain | Residue |
| A | GLY17 |
| A | HOH313 |
| A | THR18 |
| A | ARG60 |
| A | HIS61 |
| A | THR93 |
| A | ALA94 |
| A | THR197 |
| A | HOH286 |
| A | HOH294 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE PO4 B 284 |
| Chain | Residue |
| B | GLY17 |
| B | THR18 |
| B | ARG60 |
| B | HIS61 |
| B | THR93 |
| B | ALA94 |
| B | THR197 |
| B | HOH289 |
| B | HOH302 |
| B | HOH313 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE PO4 C 284 |
| Chain | Residue |
| C | GLY17 |
| C | THR18 |
| C | ARG60 |
| C | HIS61 |
| C | THR93 |
| C | ALA94 |
| C | THR197 |
| C | HOH307 |
| C | HOH309 |
| site_id | AC4 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE PO4 D 284 |
| Chain | Residue |
| D | GLY17 |
| D | THR18 |
| D | ARG60 |
| D | HIS61 |
| D | THR93 |
| D | ALA94 |
| D | THR197 |
| D | HOH290 |
| D | HOH298 |
| D | HOH305 |
| D | HOH317 |
| site_id | AC5 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE PO4 E 284 |
| Chain | Residue |
| E | GLY17 |
| E | THR18 |
| E | ARG60 |
| E | HIS61 |
| E | THR93 |
| E | ALA94 |
| E | THR197 |
| E | HOH303 |
| E | HOH325 |
| site_id | AC6 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE PO4 F 284 |
| Chain | Residue |
| F | GLY17 |
| F | THR18 |
| F | ARG60 |
| F | HIS61 |
| F | THR93 |
| F | ALA94 |
| F | THR197 |
| F | HOH303 |
| F | HOH321 |
Functional Information from PROSITE/UniProt
| site_id | PS01240 |
| Number of Residues | 41 |
| Details | PNP_MTAP_2 Purine and other phosphorylases family 2 signature. LarhGrqHtImpskVnyqAn.IwAlkeeGcth.VIvtTAcGSL |
| Chain | Residue | Details |
| A | LEU58-LEU98 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"PubMed","id":"10404592","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1CG6","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 36 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"15122881","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1K27","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"10404592","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1CB0","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | Site: {"description":"Important for substrate specificity","evidences":[{"source":"PubMed","id":"10404592","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 6 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q9CQ65","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 2 |
| Details | M-CSA 244 |
| Chain | Residue | Details |
| A | ASP220 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| A | ASP222 | electrostatic stabiliser |
| site_id | MCSA2 |
| Number of Residues | 2 |
| Details | M-CSA 244 |
| Chain | Residue | Details |
| B | ASP220 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| B | ASP222 | electrostatic stabiliser |
| site_id | MCSA3 |
| Number of Residues | 2 |
| Details | M-CSA 244 |
| Chain | Residue | Details |
| C | ASP220 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| C | ASP222 | electrostatic stabiliser |
| site_id | MCSA4 |
| Number of Residues | 2 |
| Details | M-CSA 244 |
| Chain | Residue | Details |
| D | ASP220 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| D | ASP222 | electrostatic stabiliser |
| site_id | MCSA5 |
| Number of Residues | 2 |
| Details | M-CSA 244 |
| Chain | Residue | Details |
| E | ASP220 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| E | ASP222 | electrostatic stabiliser |
| site_id | MCSA6 |
| Number of Residues | 2 |
| Details | M-CSA 244 |
| Chain | Residue | Details |
| F | ASP220 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| F | ASP222 | electrostatic stabiliser |
