3OZD
Crystal Structure of human 5'-deoxy-5'-methyladenosine phosphorylase in complex with pCl-phenylthioDADMeImmA
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003824 | molecular_function | catalytic activity |
A | 0004645 | molecular_function | 1,4-alpha-oligoglucan phosphorylase activity |
A | 0005515 | molecular_function | protein binding |
A | 0005634 | cellular_component | nucleus |
A | 0005654 | cellular_component | nucleoplasm |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0006139 | biological_process | nucleobase-containing compound metabolic process |
A | 0006166 | biological_process | purine ribonucleoside salvage |
A | 0006738 | biological_process | nicotinamide riboside catabolic process |
A | 0009116 | biological_process | nucleoside metabolic process |
A | 0016757 | molecular_function | glycosyltransferase activity |
A | 0016763 | molecular_function | pentosyltransferase activity |
A | 0017061 | molecular_function | S-methyl-5-thioadenosine phosphorylase activity |
A | 0019509 | biological_process | L-methionine salvage from methylthioadenosine |
A | 0032259 | biological_process | methylation |
A | 0033574 | biological_process | response to testosterone |
A | 0070062 | cellular_component | extracellular exosome |
B | 0003824 | molecular_function | catalytic activity |
B | 0004645 | molecular_function | 1,4-alpha-oligoglucan phosphorylase activity |
B | 0005515 | molecular_function | protein binding |
B | 0005634 | cellular_component | nucleus |
B | 0005654 | cellular_component | nucleoplasm |
B | 0005737 | cellular_component | cytoplasm |
B | 0005829 | cellular_component | cytosol |
B | 0006139 | biological_process | nucleobase-containing compound metabolic process |
B | 0006166 | biological_process | purine ribonucleoside salvage |
B | 0006738 | biological_process | nicotinamide riboside catabolic process |
B | 0009116 | biological_process | nucleoside metabolic process |
B | 0016757 | molecular_function | glycosyltransferase activity |
B | 0016763 | molecular_function | pentosyltransferase activity |
B | 0017061 | molecular_function | S-methyl-5-thioadenosine phosphorylase activity |
B | 0019509 | biological_process | L-methionine salvage from methylthioadenosine |
B | 0032259 | biological_process | methylation |
B | 0033574 | biological_process | response to testosterone |
B | 0070062 | cellular_component | extracellular exosome |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 14 |
Details | BINDING SITE FOR RESIDUE 4CT A 284 |
Chain | Residue |
A | HIS65 |
A | ASP220 |
A | ASP222 |
A | LEU237 |
A | LEU279 |
A | HOH288 |
A | ALA94 |
A | CYS95 |
A | GLY96 |
A | HIS137 |
A | PHE177 |
A | ASN195 |
A | MET196 |
A | THR219 |
site_id | AC2 |
Number of Residues | 15 |
Details | BINDING SITE FOR RESIDUE 4CT B 284 |
Chain | Residue |
B | HIS65 |
B | ALA94 |
B | CYS95 |
B | GLY96 |
B | HIS137 |
B | PHE177 |
B | ILE194 |
B | ASN195 |
B | MET196 |
B | THR219 |
B | ASP220 |
B | ASP222 |
B | VAL236 |
B | LEU240 |
B | LEU279 |
Functional Information from PROSITE/UniProt
site_id | PS01240 |
Number of Residues | 41 |
Details | PNP_MTAP_2 Purine and other phosphorylases family 2 signature. LarhGrqHtImpskVnyqAn.IwAlkeeGcth.VIvtTAcGSL |
Chain | Residue | Details |
A | LEU58-LEU98 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 12 |
Details | BINDING: |
Chain | Residue | Details |
A | THR18 | |
B | MET196 | |
B | THR197 | |
B | ASP220 | |
A | ARG60 | |
A | THR93 | |
A | MET196 | |
A | THR197 | |
A | ASP220 | |
B | THR18 | |
B | ARG60 | |
B | THR93 |
site_id | SWS_FT_FI2 |
Number of Residues | 4 |
Details | SITE: Important for substrate specificity |
Chain | Residue | Details |
A | SER178 | |
A | VAL233 | |
B | SER178 | |
B | VAL233 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q9CQ65 |
Chain | Residue | Details |
A | LYS51 | |
B | LYS51 |
Catalytic Information from CSA
site_id | MCSA1 |
Number of Residues | 2 |
Details | M-CSA 244 |
Chain | Residue | Details |
A | ASP220 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
A | ASP222 | electrostatic stabiliser |
site_id | MCSA2 |
Number of Residues | 2 |
Details | M-CSA 244 |
Chain | Residue | Details |
B | ASP220 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
B | ASP222 | electrostatic stabiliser |