Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3OZB

Crystal Structure of 5'-methylthioinosine phosphorylase from Psedomonas aeruginosa in complex with hypoxanthine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0005829	cellular_component	cytosol
A	0006166	biological_process	purine ribonucleoside salvage
A	0009116	biological_process	nucleoside metabolic process
A	0016757	molecular_function	glycosyltransferase activity
A	0016763	molecular_function	pentosyltransferase activity
A	0017061	molecular_function	S-methyl-5-thioadenosine phosphorylase activity
A	0019509	biological_process	L-methionine salvage from methylthioadenosine
B	0003824	molecular_function	catalytic activity
B	0005829	cellular_component	cytosol
B	0006166	biological_process	purine ribonucleoside salvage
B	0009116	biological_process	nucleoside metabolic process
B	0016757	molecular_function	glycosyltransferase activity
B	0016763	molecular_function	pentosyltransferase activity
B	0017061	molecular_function	S-methyl-5-thioadenosine phosphorylase activity
B	0019509	biological_process	L-methionine salvage from methylthioadenosine
C	0003824	molecular_function	catalytic activity
C	0005829	cellular_component	cytosol
C	0006166	biological_process	purine ribonucleoside salvage
C	0009116	biological_process	nucleoside metabolic process
C	0016757	molecular_function	glycosyltransferase activity
C	0016763	molecular_function	pentosyltransferase activity
C	0017061	molecular_function	S-methyl-5-thioadenosine phosphorylase activity
C	0019509	biological_process	L-methionine salvage from methylthioadenosine
D	0003824	molecular_function	catalytic activity
D	0005829	cellular_component	cytosol
D	0006166	biological_process	purine ribonucleoside salvage
D	0009116	biological_process	nucleoside metabolic process
D	0016757	molecular_function	glycosyltransferase activity
D	0016763	molecular_function	pentosyltransferase activity
D	0017061	molecular_function	S-methyl-5-thioadenosine phosphorylase activity
D	0019509	biological_process	L-methionine salvage from methylthioadenosine
E	0003824	molecular_function	catalytic activity
E	0005829	cellular_component	cytosol
E	0006166	biological_process	purine ribonucleoside salvage
E	0009116	biological_process	nucleoside metabolic process
E	0016757	molecular_function	glycosyltransferase activity
E	0016763	molecular_function	pentosyltransferase activity
E	0017061	molecular_function	S-methyl-5-thioadenosine phosphorylase activity
E	0019509	biological_process	L-methionine salvage from methylthioadenosine
F	0003824	molecular_function	catalytic activity
F	0005829	cellular_component	cytosol
F	0006166	biological_process	purine ribonucleoside salvage
F	0009116	biological_process	nucleoside metabolic process
F	0016757	molecular_function	glycosyltransferase activity
F	0016763	molecular_function	pentosyltransferase activity
F	0017061	molecular_function	S-methyl-5-thioadenosine phosphorylase activity
F	0019509	biological_process	L-methionine salvage from methylthioadenosine

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE HPA A 260

Chain	Residue
A	ALA100
A	VAL101
A	GLY102
A	LEU180
A	GLU181
A	VAL197
A	GLY198
A	MET199
A	ASN223

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 261

Chain	Residue
A	HIS105
A	GLU190
A	GLY193
E	HIS105

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 262

Chain	Residue
A	ARG53
A	GLU60
A	ALA90
D	ALA161
D	LEU162

site_id	AC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE HPA B 260

Chain	Residue
B	ALA100
B	VAL101
B	GLY102
B	GLU181
B	VAL197
B	GLY198
B	MET199
B	VAL222
B	ASN223

site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 B 261

Chain	Residue
B	GLU190
B	ASP195

site_id	AC6
Number of Residues	9
Details	BINDING SITE FOR RESIDUE HPA C 260

Chain	Residue
C	ALA100
C	VAL101
C	GLY102
C	GLU181
C	VAL197
C	GLY198
C	MET199
C	VAL222
C	ASN223

site_id	AC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE SO4 C 261

Chain	Residue
C	ASP195

site_id	AC8
Number of Residues	9
Details	BINDING SITE FOR RESIDUE HPA D 260

Chain	Residue
D	ALA100
D	VAL101
D	GLY102
D	GLU181
D	VAL197
D	GLY198
D	MET199
D	VAL222
D	ASN223

site_id	AC9
Number of Residues	8
Details	BINDING SITE FOR RESIDUE HPA E 260

Chain	Residue
E	ALA100
E	VAL101
E	GLY102
E	GLU181
E	VAL197
E	GLY198
E	VAL222
E	ASN223

site_id	BC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE HPA F 260

Chain	Residue
F	ALA100
F	VAL101
F	GLY102
F	GLU181
F	VAL197
F	GLY198
F	MET199
F	ASN223
F	HOH263

Functional Information from PROSITE/UniProt

site_id	PS01240
Number of Residues	41
Details	PNP_MTAP_2 Purine and other phosphorylases family 2 signature. LarhGhpHrFpphqVnyrAn.LwAlkqaGaea.VIavNAvGGI

Chain	Residue	Details
A	LEU64-ILE104

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	BINDING: BINDING => ECO:0000255\|HAMAP-Rule:MF_01963

Chain	Residue	Details
D	THR24
D	ARG66
D	MET199
D	THR200
E	THR24
E	ARG66
E	MET199
E	THR200
F	THR24
F	ARG66
F	MET199
F	THR200
A	THR24
A	ARG66
A	MET199
A	THR200
B	THR24
B	ARG66
B	MET199
B	THR200
C	THR24
C	ARG66
C	MET199
C	THR200

site_id	SWS_FT_FI2
Number of Residues	6
Details	BINDING:

Chain	Residue	Details
D	ASN223
E	ASN223
F	ASN223
A	ASN223
B	ASN223
C	ASN223

site_id	SWS_FT_FI3
Number of Residues	6
Details	SITE: Important for substrate specificity

Chain	Residue	Details
D	GLU181
E	GLU181
F	GLU181
A	GLU181
B	GLU181
C	GLU181

site_id	SWS_FT_FI4
Number of Residues	6
Details	SITE: Important for substrate specificity => ECO:0000255\|HAMAP-Rule:MF_01963

Chain	Residue	Details
A	MET235
B	MET235
C	MET235
D	MET235
E	MET235
F	MET235

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)