3OZB
Crystal Structure of 5'-methylthioinosine phosphorylase from Psedomonas aeruginosa in complex with hypoxanthine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0006166 | biological_process | purine ribonucleoside salvage |
| A | 0009116 | biological_process | nucleoside metabolic process |
| A | 0016763 | molecular_function | pentosyltransferase activity |
| A | 0017061 | molecular_function | S-methyl-5-thioadenosine phosphorylase activity |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0006166 | biological_process | purine ribonucleoside salvage |
| B | 0009116 | biological_process | nucleoside metabolic process |
| B | 0016763 | molecular_function | pentosyltransferase activity |
| B | 0017061 | molecular_function | S-methyl-5-thioadenosine phosphorylase activity |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0005829 | cellular_component | cytosol |
| C | 0006166 | biological_process | purine ribonucleoside salvage |
| C | 0009116 | biological_process | nucleoside metabolic process |
| C | 0016763 | molecular_function | pentosyltransferase activity |
| C | 0017061 | molecular_function | S-methyl-5-thioadenosine phosphorylase activity |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0005829 | cellular_component | cytosol |
| D | 0006166 | biological_process | purine ribonucleoside salvage |
| D | 0009116 | biological_process | nucleoside metabolic process |
| D | 0016763 | molecular_function | pentosyltransferase activity |
| D | 0017061 | molecular_function | S-methyl-5-thioadenosine phosphorylase activity |
| E | 0003824 | molecular_function | catalytic activity |
| E | 0005829 | cellular_component | cytosol |
| E | 0006166 | biological_process | purine ribonucleoside salvage |
| E | 0009116 | biological_process | nucleoside metabolic process |
| E | 0016763 | molecular_function | pentosyltransferase activity |
| E | 0017061 | molecular_function | S-methyl-5-thioadenosine phosphorylase activity |
| F | 0003824 | molecular_function | catalytic activity |
| F | 0005829 | cellular_component | cytosol |
| F | 0006166 | biological_process | purine ribonucleoside salvage |
| F | 0009116 | biological_process | nucleoside metabolic process |
| F | 0016763 | molecular_function | pentosyltransferase activity |
| F | 0017061 | molecular_function | S-methyl-5-thioadenosine phosphorylase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE HPA A 260 |
| Chain | Residue |
| A | ALA100 |
| A | VAL101 |
| A | GLY102 |
| A | LEU180 |
| A | GLU181 |
| A | VAL197 |
| A | GLY198 |
| A | MET199 |
| A | ASN223 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 261 |
| Chain | Residue |
| A | HIS105 |
| A | GLU190 |
| A | GLY193 |
| E | HIS105 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 262 |
| Chain | Residue |
| A | ARG53 |
| A | GLU60 |
| A | ALA90 |
| D | ALA161 |
| D | LEU162 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE HPA B 260 |
| Chain | Residue |
| B | ALA100 |
| B | VAL101 |
| B | GLY102 |
| B | GLU181 |
| B | VAL197 |
| B | GLY198 |
| B | MET199 |
| B | VAL222 |
| B | ASN223 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 B 261 |
| Chain | Residue |
| B | GLU190 |
| B | ASP195 |
| site_id | AC6 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE HPA C 260 |
| Chain | Residue |
| C | ALA100 |
| C | VAL101 |
| C | GLY102 |
| C | GLU181 |
| C | VAL197 |
| C | GLY198 |
| C | MET199 |
| C | VAL222 |
| C | ASN223 |
| site_id | AC7 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE SO4 C 261 |
| Chain | Residue |
| C | ASP195 |
| site_id | AC8 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE HPA D 260 |
| Chain | Residue |
| D | ALA100 |
| D | VAL101 |
| D | GLY102 |
| D | GLU181 |
| D | VAL197 |
| D | GLY198 |
| D | MET199 |
| D | VAL222 |
| D | ASN223 |
| site_id | AC9 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE HPA E 260 |
| Chain | Residue |
| E | ALA100 |
| E | VAL101 |
| E | GLY102 |
| E | GLU181 |
| E | VAL197 |
| E | GLY198 |
| E | VAL222 |
| E | ASN223 |
| site_id | BC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE HPA F 260 |
| Chain | Residue |
| F | ALA100 |
| F | VAL101 |
| F | GLY102 |
| F | GLU181 |
| F | VAL197 |
| F | GLY198 |
| F | MET199 |
| F | ASN223 |
| F | HOH263 |
Functional Information from PROSITE/UniProt
| site_id | PS01240 |
| Number of Residues | 41 |
| Details | PNP_MTAP_2 Purine and other phosphorylases family 2 signature. LarhGhpHrFpphqVnyrAn.LwAlkqaGaea.VIavNAvGGI |
| Chain | Residue | Details |
| A | LEU64-ILE104 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 24 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01963","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Site: {"description":"Important for substrate specificity"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | Site: {"description":"Important for substrate specificity","evidences":[{"source":"HAMAP-Rule","id":"MF_01963","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
