3OXO

Succinyl-CoA:3-ketoacid CoA transferase from pig heart covalently bound to CoA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005739	cellular_component	mitochondrion
A	0008260	molecular_function	succinyl-CoA:3-oxo-acid CoA-transferase activity
A	0008410	molecular_function	CoA-transferase activity
A	0042803	molecular_function	protein homodimerization activity
A	0046952	biological_process	ketone body catabolic process
B	0005739	cellular_component	mitochondrion
B	0008260	molecular_function	succinyl-CoA:3-oxo-acid CoA-transferase activity
B	0008410	molecular_function	CoA-transferase activity
B	0042803	molecular_function	protein homodimerization activity
B	0046952	biological_process	ketone body catabolic process
C	0005739	cellular_component	mitochondrion
C	0008260	molecular_function	succinyl-CoA:3-oxo-acid CoA-transferase activity
C	0008410	molecular_function	CoA-transferase activity
C	0042803	molecular_function	protein homodimerization activity
C	0046952	biological_process	ketone body catabolic process
D	0005739	cellular_component	mitochondrion
D	0008260	molecular_function	succinyl-CoA:3-oxo-acid CoA-transferase activity
D	0008410	molecular_function	CoA-transferase activity
D	0042803	molecular_function	protein homodimerization activity
D	0046952	biological_process	ketone body catabolic process
E	0005739	cellular_component	mitochondrion
E	0008260	molecular_function	succinyl-CoA:3-oxo-acid CoA-transferase activity
E	0008410	molecular_function	CoA-transferase activity
E	0042803	molecular_function	protein homodimerization activity
E	0046952	biological_process	ketone body catabolic process
F	0005739	cellular_component	mitochondrion
F	0008260	molecular_function	succinyl-CoA:3-oxo-acid CoA-transferase activity
F	0008410	molecular_function	CoA-transferase activity
F	0042803	molecular_function	protein homodimerization activity
F	0046952	biological_process	ketone body catabolic process
G	0005739	cellular_component	mitochondrion
G	0008260	molecular_function	succinyl-CoA:3-oxo-acid CoA-transferase activity
G	0008410	molecular_function	CoA-transferase activity
G	0042803	molecular_function	protein homodimerization activity
G	0046952	biological_process	ketone body catabolic process
H	0005739	cellular_component	mitochondrion
H	0008260	molecular_function	succinyl-CoA:3-oxo-acid CoA-transferase activity
H	0008410	molecular_function	CoA-transferase activity
H	0042803	molecular_function	protein homodimerization activity
H	0046952	biological_process	ketone body catabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	BINDING SITE FOR RESIDUE COA E 1305

Chain	Residue
E	TYR76
E	GLY383
E	MET384
E	ALA387
E	GLU403
E	LYS407
E	HOH521
E	HOH536
E	HOH537
E	ILE284
E	GLY285
E	ILE286
E	GLU305
E	GLY361
E	MET363
E	ASN373
E	ILE376

---

site_id	AC2
Number of Residues	18
Details	BINDING SITE FOR RESIDUE COA F 1305

Chain	Residue
F	TYR76
F	ILE284
F	GLY285
F	ILE286
F	GLU305
F	GLY361
F	MET363
F	ASN373
F	ILE376
F	GLY383
F	MET384
F	ALA387
F	GLU403
F	ALA406
F	LYS407
F	LYS412
F	HOH491
F	HOH531

---

site_id	AC3
Number of Residues	19
Details	BINDING SITE FOR RESIDUE COA G 1305

Chain	Residue
G	TYR76
G	ILE284
G	GLY285
G	ILE286
G	GLU305
G	GLY361
G	MET363
G	ASN373
G	ILE376
G	LYS382
G	GLY383
G	MET384
G	GLU403
G	ALA406
G	LYS407
G	LYS412
G	HOH490
G	HOH498
G	HOH513

---

site_id	AC4
Number of Residues	15
Details	BINDING SITE FOR RESIDUE COA H 1305

Chain	Residue
H	TYR76
H	ILE284
H	GLY285
H	ILE286
H	GLU305
H	GLY361
H	MET363
H	ASN373
H	ILE376
H	GLY383
H	MET384
H	GLU403
H	ALA406
H	LYS407
H	HOH512

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CL C 489

Chain	Residue
C	PHE25
C	ASN51
C	ASN52
C	TYR76
C	GLN99
C	LYS329

---

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CL D 489

Chain	Residue
D	PHE25
D	ASN52
D	TYR76
D	GLN99
D	LYS329
D	HOH531

---

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CL B 489

Chain	Residue
B	PHE25
B	ASN51
B	ASN52
B	TYR76
B	GLN99
B	LYS329

---

Functional Information from PROSITE/UniProt

site_id	PS01273
Number of Residues	16
Details	COA_TRANSF_1 Coenzyme A transferases signature 1. NGatVLVGGFglcGiP

Chain	Residue	Details
A	ASN16-PRO31

---

site_id	PS01274
Number of Residues	9
Details	COA_TRANSF_2 Coenzyme A transferases signature 2. LQSENGILG

Chain	Residue	Details
A	LEU302-GLY310

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Active site: {"description":"5-glutamyl coenzyme A thioester intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU10034","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"7915164","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P55809","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	32
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"Q9D0K2","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---