3OX7

The crystal structure of uPA complex with peptide inhibitor MH027 at pH4.6

Functional Information from GO Data

Chain	GOid	namespace	contents
U	0004252	molecular_function	serine-type endopeptidase activity
U	0006508	biological_process	proteolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 U 1

Chain	Residue
U	ASN87
U	PRO170
U	HIS170
U	HOH300

---

site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PG4 U 6112

Chain	Residue
U	ALA184
U	PRO185
U	TRP186
U	LYS161
U	LEU162
U	ILE163
U	GLU167
U	TYR171

---

site_id	AC3
Number of Residues	25
Details	BINDING SITE FOR CHAIN P OF MH027

Chain	Residue
P	HOH39
P	HOH41
P	HOH45
P	HOH132
P	HOH156
U	ARG35
U	PRO49
U	HIS57
U	CYS58
U	ASP60
U	TYR60
U	TYR64
U	HIS99
U	ASP189
U	SER190
U	CYS191
U	GLN192
U	GLY193
U	SER195
U	SER214
U	TRP215
U	GLY216
U	GLY219
U	GLY226
U	HOH364

---

Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. ISATHC

Chain	Residue	Details
U	ILE53-CYS58

---

site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. DScqGDSGGPLV

Chain	Residue	Details
U	ASP189-VAL200

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	Active site: {"description":"Charge relay system"}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"9151681","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","featureId":"CAR_000026"}

Chain

Residue

Details

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