3OVQ

Crystal Structure of hRPE and D-Ribulose-5-Phospate Complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004750	molecular_function	D-ribulose-phosphate 3-epimerase activity
A	0005515	molecular_function	protein binding
A	0005829	cellular_component	cytosol
A	0005975	biological_process	carbohydrate metabolic process
A	0006098	biological_process	pentose-phosphate shunt
A	0009052	biological_process	pentose-phosphate shunt, non-oxidative branch
A	0016853	molecular_function	isomerase activity
A	0016857	molecular_function	racemase and epimerase activity, acting on carbohydrates and derivatives
A	0042802	molecular_function	identical protein binding
A	0042803	molecular_function	protein homodimerization activity
A	0046872	molecular_function	metal ion binding
A	0070062	cellular_component	extracellular exosome
B	0004750	molecular_function	D-ribulose-phosphate 3-epimerase activity
B	0005515	molecular_function	protein binding
B	0005829	cellular_component	cytosol
B	0005975	biological_process	carbohydrate metabolic process
B	0006098	biological_process	pentose-phosphate shunt
B	0009052	biological_process	pentose-phosphate shunt, non-oxidative branch
B	0016853	molecular_function	isomerase activity
B	0016857	molecular_function	racemase and epimerase activity, acting on carbohydrates and derivatives
B	0042802	molecular_function	identical protein binding
B	0042803	molecular_function	protein homodimerization activity
B	0046872	molecular_function	metal ion binding
B	0070062	cellular_component	extracellular exosome

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FE2 A 229

Chain	Residue
A	HIS35
A	ASP37
A	HIS70
A	ASP175
A	5RP230

---

site_id	AC2
Number of Residues	20
Details	BINDING SITE FOR RESIDUE 5RP A 230

Chain	Residue
A	MET72
A	PRO145
A	GLY146
A	PHE147
A	GLY148
A	GLY149
A	ASP175
A	GLY176
A	GLY177
A	GLY197
A	SER198
A	FE2229
A	HOH238
A	HOH248
A	HOH251
A	HOH258
A	SER10
A	HIS35
A	ASP37
A	HIS70

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE XPE A 231

Chain	Residue
A	LYS6
A	ASP32
A	PHE66
A	ASP171
A	MET193

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE XPE A 232

Chain	Residue
A	ARG58
A	GLN63
A	PHE66
A	ASN89
A	GLY112

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE XPE A 233

Chain	Residue
A	PRO158
A	HIS161
A	TRP162
A	GLU188

---

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE XPE A 234

Chain	Residue
A	ASN100
A	TRP131

---

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FE2 B 229

Chain	Residue
B	HIS35
B	ASP37
B	HIS70
B	ASP175
B	5RP230

---

site_id	AC8
Number of Residues	20
Details	BINDING SITE FOR RESIDUE 5RP B 230

Chain	Residue
B	SER10
B	HIS35
B	ASP37
B	MET39
B	HIS70
B	MET72
B	PRO145
B	GLY146
B	PHE147
B	GLY148
B	GLY149
B	ASP175
B	GLY176
B	GLY177
B	GLY197
B	SER198
B	FE2229
B	HOH238
B	HOH273
B	HOH293

---

site_id	AC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE XPE B 231

Chain	Residue
B	LYS6
B	ASP32
B	ASP171

---

site_id	BC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE XPE B 232

Chain	Residue
B	THR123

---

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE XPE B 233

Chain	Residue
B	GLY87
B	ALA88
B	ASN89
B	GLY112
B	LYS114

---

Functional Information from PROSITE/UniProt

site_id	PS01085
Number of Residues	15
Details	RIBUL_P_3_EPIMER_1 Ribulose-phosphate 3-epimerase family signature 1. LHLDVmDghFVpNiT

Chain	Residue	Details
A	LEU34-THR48

---

site_id	PS01086
Number of Residues	23
Details	RIBUL_P_3_EPIMER_2 Ribulose-phosphate 3-epimerase family signature 2. AlVMTVePgfgGQkFmedmmpKV

Chain	Residue	Details
A	ALA138-VAL160

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"20923965","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3OVQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3OVR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Active site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"20923965","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3OVQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3OVR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20923965","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3OVR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20923965","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"MAR-2011","submissionDatabase":"PDB data bank","title":"Crystal structure of a D-ribulose-5-phosphate-3-epimerase (NP_954699) from Homo sapiens at 2.20 A resolution.","authoringGroup":["Joint center for structural genomics (JCSG)"]}},{"source":"PDB","id":"3OVP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3OVQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3OVR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3QC3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20923965","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3OVQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3OVR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---