3OVB

How the CCA-adding Enzyme Selects Adenine over Cytosine in Position 76 of tRNA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000049	molecular_function	tRNA binding
A	0000287	molecular_function	magnesium ion binding
A	0001680	biological_process	tRNA 3'-terminal CCA addition
A	0003723	molecular_function	RNA binding
A	0004810	molecular_function	CCA tRNA nucleotidyltransferase activity
A	0005524	molecular_function	ATP binding
A	0008033	biological_process	tRNA processing
A	0016779	molecular_function	nucleotidyltransferase activity
A	0031123	biological_process	RNA 3'-end processing
A	0042245	biological_process	RNA repair
A	0046872	molecular_function	metal ion binding
A	0106354	biological_process	tRNA surveillance
A	0160016	molecular_function	CCACCA tRNA nucleotidyltransferase activity
B	0000049	molecular_function	tRNA binding
B	0000287	molecular_function	magnesium ion binding
B	0001680	biological_process	tRNA 3'-terminal CCA addition
B	0003723	molecular_function	RNA binding
B	0004810	molecular_function	CCA tRNA nucleotidyltransferase activity
B	0005524	molecular_function	ATP binding
B	0008033	biological_process	tRNA processing
B	0016779	molecular_function	nucleotidyltransferase activity
B	0031123	biological_process	RNA 3'-end processing
B	0042245	biological_process	RNA repair
B	0046872	molecular_function	metal ion binding
B	0106354	biological_process	tRNA surveillance
B	0160016	molecular_function	CCACCA tRNA nucleotidyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	23
Details	BINDING SITE FOR RESIDUE ATP A 501

Chain	Residue
A	GLY46
A	ALA163
A	TYR173
A	ARG224
A	HOH448
A	HOH449
A	HOH455
A	HOH462
A	HOH505
A	HOH554
A	HOH565
A	SER47
A	MG901
C	A32
C	C33
C	C34
A	ARG50
A	GLU59
A	ASP61
A	THR130
A	HIS133
A	LYS152
A	TYR161

---

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 701

Chain	Residue
A	ARG299
A	ARG302
A	LYS303

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 801

Chain	Residue
A	TRP397
A	GLU406
A	ARG409
A	GLU410

---

site_id	AC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE EDO A 803

Chain	Residue
A	VAL40
A	GLU41
A	LEU64
A	LEU65
A	PHE66
A	ASP437
A	HOH481
A	HOH729
A	HOH734

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 804

Chain	Residue
A	ARG78
A	LYS436
A	ASP437
B	ARG366
B	EDO802

---

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 805

Chain	Residue
A	HIS398
C	U23
C	U24

---

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 901

Chain	Residue
A	GLU59
A	ASP61
A	ATP501
C	A35
C	POP601

---

site_id	AC8
Number of Residues	14
Details	BINDING SITE FOR RESIDUE ATP B 502

Chain	Residue
B	GLY46
B	SER47
B	ARG50
B	ASP61
B	THR130
B	HIS133
B	LYS152
B	TYR161
B	TYR173
B	ARG224
B	MG902
D	A32
D	C33
D	C34

---

site_id	AC9
Number of Residues	10
Details	BINDING SITE FOR RESIDUE POP B 602

Chain	Residue
B	GLY46
B	SER47
B	LYS152
B	TYR161
B	GLY172
B	TYR173
B	GLU176
B	HOH511
B	MG902
D	A35

---

site_id	BC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 B 702

Chain	Residue
B	ARG299
B	ARG302
B	LYS303

---

site_id	BC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO B 802

Chain	Residue
A	LYS257
A	VAL435
A	ASP437
A	CYS438
A	CYS439
A	EDO804
B	ARG366

---

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG B 902

Chain	Residue
B	GLU59
B	ASP61
B	ATP502
B	POP602
D	A35

---

site_id	BC4
Number of Residues	12
Details	BINDING SITE FOR RESIDUE POP C 601

Chain	Residue
A	MG901
C	A35
C	HOH478
C	HOH485
A	GLY46
A	SER47
A	ASP61
A	TYR161
A	GLY172
A	HOH448
A	HOH554
A	HOH565

---

site_id	BC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ATP C 851

Chain	Residue
C	U14
C	A16
C	A17
C	U19

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:14592988, ECO:0000269|PubMed:14636575, ECO:0000269|PubMed:25640237, ECO:0007744|PDB:1R89, ECO:0007744|PDB:1UEU, ECO:0007744|PDB:4X4O, ECO:0007744|PDB:4X4Q, ECO:0007744|PDB:4X4S

Chain	Residue	Details
A	SER47
B	SER47

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269|PubMed:14592988, ECO:0000269|PubMed:14636575, ECO:0000269|PubMed:25640237, ECO:0007744|PDB:1R89, ECO:0007744|PDB:1UEU, ECO:0007744|PDB:4X4Q, ECO:0007744|PDB:4X4S

Chain	Residue	Details
A	ARG50
A	HIS133
A	LYS152
A	TYR161
B	ARG50
B	HIS133
B	LYS152
B	TYR161

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:14592988, ECO:0007744|PDB:1UEV

Chain	Residue	Details
A	GLU59
B	GLU59

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:14592988, ECO:0007744|PDB:1R89, ECO:0007744|PDB:1UEV

Chain	Residue	Details
A	ASP61
A	ASP110
B	ASP61
B	ASP110

---