3OVA

How the CCA-adding Enzyme Selects Adenine over Cytosine in Position 76 of tRNA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000049	molecular_function	tRNA binding
A	0000166	molecular_function	nucleotide binding
A	0000287	molecular_function	magnesium ion binding
A	0001680	biological_process	tRNA 3'-terminal CCA addition
A	0003723	molecular_function	RNA binding
A	0004810	molecular_function	CCA tRNA nucleotidyltransferase activity
A	0005524	molecular_function	ATP binding
A	0008033	biological_process	tRNA processing
A	0016740	molecular_function	transferase activity
A	0016779	molecular_function	nucleotidyltransferase activity
A	0031123	biological_process	RNA 3'-end processing
A	0042245	biological_process	RNA repair
A	0046872	molecular_function	metal ion binding
A	0106354	biological_process	tRNA surveillance
A	0160016	molecular_function	CCACCA tRNA nucleotidyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	22
Details	BINDING SITE FOR RESIDUE APC A 501

Chain	Residue
A	HOH1
A	LYS152
A	TYR161
A	ARG224
A	HOH448
A	HOH519
A	HOH543
A	HOH561
A	HOH567
A	HOH572
A	MG601
A	HOH2
C	A32
C	C33
C	C34
A	GLY46
A	SER47
A	ARG50
A	GLU59
A	ASP61
A	THR130
A	HIS133

---

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 503

Chain	Residue
A	ARG299
A	ARG302
A	LYS303

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site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG A 601

Chain	Residue
A	SER47
A	GLU59
A	ASP61
A	APC501

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 701

Chain	Residue
A	VAL40
A	GLU41
A	LEU64
A	LEU65
A	PHE66

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 702

Chain	Residue
A	ARG140
A	ILE408
A	ARG409
A	TYR411
A	PHE412

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 703

Chain	Residue
A	ILE123
A	LYS124
A	SER125
A	ALA126
A	HOH545

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI4
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"14592988","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14636575","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25640237","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1R89","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1UEU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4X4O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4X4Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4X4S","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"14592988","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14636575","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25640237","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1R89","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1UEU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4X4Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4X4S","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI6
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"14592988","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1UEV","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI7
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"14592988","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1R89","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1UEV","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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