3OV2
Curcumin synthase 1 from Curcuma longa
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0009058 | biological_process | biosynthetic process |
| A | 0009813 | biological_process | flavonoid biosynthetic process |
| A | 0016746 | molecular_function | acyltransferase activity |
| A | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| A | 0030639 | biological_process | polyketide biosynthetic process |
| A | 0102106 | molecular_function | curcumin synthase activity |
| B | 0009058 | biological_process | biosynthetic process |
| B | 0009813 | biological_process | flavonoid biosynthetic process |
| B | 0016746 | molecular_function | acyltransferase activity |
| B | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| B | 0030639 | biological_process | polyketide biosynthetic process |
| B | 0102106 | molecular_function | curcumin synthase activity |
| C | 0009058 | biological_process | biosynthetic process |
| C | 0009813 | biological_process | flavonoid biosynthetic process |
| C | 0016746 | molecular_function | acyltransferase activity |
| C | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| C | 0030639 | biological_process | polyketide biosynthetic process |
| C | 0102106 | molecular_function | curcumin synthase activity |
| D | 0009058 | biological_process | biosynthetic process |
| D | 0009813 | biological_process | flavonoid biosynthetic process |
| D | 0016746 | molecular_function | acyltransferase activity |
| D | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| D | 0030639 | biological_process | polyketide biosynthetic process |
| D | 0102106 | molecular_function | curcumin synthase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MLI A 394 |
| Chain | Residue |
| A | CYS164 |
| A | HIS303 |
| A | ASN336 |
| A | PHE373 |
| A | GLY374 |
| A | HOH480 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE MLI D 394 |
| Chain | Residue |
| D | THR194 |
| D | VAL195 |
| D | LEU196 |
| D | SER197 |
| D | PHE265 |
| D | GLN338 |
| D | HOH534 |
| D | ILE132 |
| D | SER133 |
| D | ILE193 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MLI A 395 |
| Chain | Residue |
| A | THR24 |
| A | TYR334 |
| A | PHE344 |
| A | ASP347 |
| A | GLU348 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE MLI D 395 |
| Chain | Residue |
| C | THR246 |
| D | ALA145 |
| D | THR146 |
| D | LEU150 |
| D | PRO151 |
| D | LEU152 |
| D | VAL154 |
| D | ARG156 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MLI B 394 |
| Chain | Residue |
| B | CYS164 |
| B | LEU271 |
| B | HIS303 |
| B | GLY305 |
| B | ASN336 |
| B | PHE373 |
| B | MLI396 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MLI D 396 |
| Chain | Residue |
| D | CYS164 |
| D | LEU271 |
| D | ASN336 |
| D | EDO402 |
| D | HOH494 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MLI B 395 |
| Chain | Residue |
| B | PRO27 |
| B | PRO28 |
| B | HIS71 |
| B | GLU101 |
| B | HOH483 |
| site_id | AC8 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE MLI A 396 |
| Chain | Residue |
| A | ASP141 |
| A | ARG156 |
| A | LEU157 |
| A | MET158 |
| B | GLN162 |
| B | HIS165 |
| B | MET166 |
| B | ALA169 |
| B | ARG172 |
| B | GLN244 |
| B | GLU380 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MLI B 396 |
| Chain | Residue |
| B | GLY214 |
| B | GLY305 |
| B | ASN306 |
| B | ASN336 |
| B | MLI394 |
| B | HOH532 |
| site_id | BC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MLI A 397 |
| Chain | Residue |
| A | ALA145 |
| A | THR146 |
| A | LEU150 |
| A | PRO151 |
| A | LEU152 |
| A | ARG156 |
| B | THR246 |
| site_id | BC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MLI D 397 |
| Chain | Residue |
| B | GLY252 |
| D | LYS107 |
| D | LEU147 |
| D | HOH417 |
| site_id | BC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MLI B 397 |
| Chain | Residue |
| A | MET243 |
| A | GLN244 |
| A | ARG285 |
| B | THR153 |
| B | ASN155 |
| site_id | BC4 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE MLI A 398 |
| Chain | Residue |
| A | ILE132 |
| A | SER133 |
| A | ILE193 |
| A | THR194 |
| A | VAL195 |
| A | LEU196 |
| A | SER197 |
| A | TRP263 |
| A | PHE265 |
| A | GLN338 |
| A | HOH461 |
| site_id | BC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MLI C 394 |
| Chain | Residue |
| C | CYS164 |
| C | ASN336 |
| C | PHE373 |
| C | GLY374 |
| C | EDO401 |
| C | HOH443 |
| site_id | BC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO B 398 |
| Chain | Residue |
| B | ARG119 |
| B | GLY183 |
| B | HOH476 |
| site_id | BC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO B 399 |
| Chain | Residue |
| B | ALA145 |
| B | THR146 |
| B | LEU150 |
| B | PRO151 |
| site_id | BC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 399 |
| Chain | Residue |
| A | LEU258 |
| A | ARG259 |
| A | EDO412 |
| B | GLN95 |
| B | HOH490 |
| site_id | BC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO B 400 |
| Chain | Residue |
| B | LEU30 |
| B | TYR31 |
| B | GLU32 |
| B | THR35 |
| B | PHE36 |
| site_id | CC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO B 401 |
| Chain | Residue |
| B | THR24 |
| B | PHE344 |
| B | ASP347 |
| B | GLU348 |
| B | HOH525 |
| site_id | CC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO C 395 |
| Chain | Residue |
| C | TYR31 |
| C | GLU32 |
| C | THR35 |
| C | PHE36 |
| site_id | CC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 400 |
| Chain | Residue |
| A | GLU207 |
| A | GLY252 |
| A | TYR266 |
| A | HOH475 |
| site_id | CC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 401 |
| Chain | Residue |
| A | ASP297 |
| A | LEU365 |
| A | GLN366 |
| A | TRP367 |
| site_id | CC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO D 398 |
| Chain | Residue |
| D | THR24 |
| D | PHE344 |
| D | ASP347 |
| D | GLU348 |
| site_id | CC6 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE EDO B 402 |
| Chain | Residue |
| B | ASP277 |
| site_id | CC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO A 402 |
| Chain | Residue |
| A | HIS126 |
| A | ASN155 |
| A | ARG156 |
| A | LEU157 |
| A | LEU177 |
| A | HOH433 |
| B | ARG172 |
| site_id | CC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO D 399 |
| Chain | Residue |
| D | ASP322 |
| D | SER325 |
| D | THR326 |
| D | ARG352 |
| D | ASP363 |
| site_id | CC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO B 403 |
| Chain | Residue |
| B | ASP297 |
| B | GLN366 |
| B | TRP367 |
| site_id | DC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO C 396 |
| Chain | Residue |
| C | GLU249 |
| C | GLN251 |
| C | GLY252 |
| site_id | DC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE EDO A 403 |
| Chain | Residue |
| A | TRP307 |
| A | ASP311 |
| site_id | DC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO D 400 |
| Chain | Residue |
| C | ASP92 |
| D | ARG259 |
| D | PHE261 |
| site_id | DC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO D 401 |
| Chain | Residue |
| D | ASN269 |
| D | GLN270 |
| D | HOH433 |
| site_id | DC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO B 404 |
| Chain | Residue |
| B | THR194 |
| B | SER197 |
| B | GLY211 |
| B | GLN212 |
| B | PHE215 |
| site_id | DC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE EDO C 397 |
| Chain | Residue |
| C | TRP307 |
| C | ASP311 |
| site_id | DC7 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE EDO C 398 |
| Chain | Residue |
| C | GLY139 |
| C | ASP141 |
| C | ARG156 |
| D | GLN162 |
| D | ALA163 |
| D | HIS165 |
| D | PRO375 |
| D | EDO410 |
| site_id | DC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO C 399 |
| Chain | Residue |
| C | GLN33 |
| C | CYS60 |
| C | GLU61 |
| C | HOH553 |
| site_id | DC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO C 400 |
| Chain | Residue |
| C | GLU32 |
| C | GLN33 |
| C | SER34 |
| C | LYS66 |
| site_id | EC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO D 402 |
| Chain | Residue |
| D | GLY305 |
| D | ASN306 |
| D | MLI396 |
| site_id | EC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO C 401 |
| Chain | Residue |
| C | GLY305 |
| C | ASN306 |
| C | MLI394 |
| C | HOH453 |
| site_id | EC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 404 |
| Chain | Residue |
| A | LYS53 |
| A | LYS54 |
| A | ARG57 |
| A | HOH526 |
| site_id | EC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE EDO B 405 |
| Chain | Residue |
| B | GLU356 |
| D | SER325 |
| site_id | EC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO B 406 |
| Chain | Residue |
| B | ARG182 |
| B | GLY183 |
| B | ASP227 |
| site_id | EC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO C 402 |
| Chain | Residue |
| C | ALA145 |
| C | LEU150 |
| C | PRO151 |
| C | LEU152 |
| C | ARG156 |
| C | HOH516 |
| D | THR246 |
| site_id | EC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO C 403 |
| Chain | Residue |
| C | HIS126 |
| C | ASN155 |
| C | LEU157 |
| C | LEU177 |
| D | ARG172 |
| D | HOH515 |
| site_id | EC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 405 |
| Chain | Residue |
| A | LYS234 |
| A | PRO235 |
| A | THR361 |
| A | HOH435 |
| A | HOH524 |
| site_id | EC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO D 403 |
| Chain | Residue |
| D | ARG182 |
| D | GLY183 |
| D | ALA184 |
| site_id | FC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE EDO B 407 |
| Chain | Residue |
| B | GLU88 |
| B | ALA89 |
| site_id | FC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 406 |
| Chain | Residue |
| A | GLN95 |
| A | ILE132 |
| A | GLY134 |
| A | ILE135 |
| A | SER161 |
| A | TRP263 |
| site_id | FC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO B 408 |
| Chain | Residue |
| B | GLN95 |
| B | ILE132 |
| B | GLY134 |
| B | ILE135 |
| B | SER161 |
| B | LEU196 |
| B | TRP263 |
| site_id | FC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE EDO D 404 |
| Chain | Residue |
| D | GLN95 |
| D | ILE132 |
| D | SER133 |
| D | GLY134 |
| D | ILE135 |
| D | SER161 |
| D | LEU196 |
| D | TRP263 |
| site_id | FC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO D 405 |
| Chain | Residue |
| D | HIS71 |
| D | ILE97 |
| D | GLU101 |
| D | EDO406 |
| site_id | FC6 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE EDO B 409 |
| Chain | Residue |
| B | SER133 |
| B | ILE193 |
| B | THR194 |
| B | VAL195 |
| B | LEU196 |
| B | SER197 |
| B | GLN338 |
| B | HOH491 |
| site_id | FC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO C 404 |
| Chain | Residue |
| C | ARG80 |
| C | PRO81 |
| C | LYS82 |
| C | ASP93 |
| site_id | FC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO A 407 |
| Chain | Residue |
| A | SER197 |
| A | ARG199 |
| A | GLN212 |
| A | TRP263 |
| A | THR264 |
| A | PHE265 |
| A | HOH459 |
| site_id | FC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 408 |
| Chain | Residue |
| A | ASP277 |
| A | HOH481 |
| C | GLN50 |
| C | GLU51 |
| site_id | GC1 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE EDO B 410 |
| Chain | Residue |
| B | GLU123 |
| site_id | GC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO B 411 |
| Chain | Residue |
| A | ASP48 |
| A | GLN50 |
| B | ILE114 |
| B | GLY118 |
| B | ARG119 |
| B | HOH455 |
| site_id | GC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 409 |
| Chain | Residue |
| A | GLU249 |
| A | SER250 |
| A | GLN251 |
| A | GLY252 |
| A | ALA253 |
| C | LYS54 |
| site_id | GC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE EDO C 405 |
| Chain | Residue |
| C | GLN95 |
| C | ILE132 |
| C | SER133 |
| C | GLY134 |
| C | ILE135 |
| C | SER161 |
| C | LEU196 |
| C | TRP263 |
| site_id | GC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE EDO B 412 |
| Chain | Residue |
| A | ARG172 |
| B | HIS126 |
| B | LEU127 |
| B | ASN155 |
| B | ARG156 |
| B | LEU157 |
| B | LEU177 |
| B | HOH459 |
| site_id | GC6 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE EDO A 410 |
| Chain | Residue |
| A | GLN162 |
| A | HIS165 |
| A | MET166 |
| A | GLN244 |
| B | ASP141 |
| B | ARG156 |
| B | LEU157 |
| B | MET158 |
| site_id | GC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO D 406 |
| Chain | Residue |
| B | GLU203 |
| D | ILE76 |
| D | GLU79 |
| D | ARG80 |
| D | EDO405 |
| site_id | GC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 411 |
| Chain | Residue |
| A | LEU30 |
| A | TYR31 |
| A | GLU32 |
| A | THR35 |
| A | PHE36 |
| site_id | GC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO D 407 |
| Chain | Residue |
| D | LEU30 |
| D | TYR31 |
| D | GLU32 |
| D | THR35 |
| D | PHE39 |
| D | HOH504 |
| site_id | HC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO B 413 |
| Chain | Residue |
| B | LYS55 |
| B | PHE206 |
| D | GLU79 |
| site_id | HC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO A 412 |
| Chain | Residue |
| A | HIS257 |
| A | EDO399 |
| B | ASP136 |
| site_id | HC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO D 408 |
| Chain | Residue |
| D | SER197 |
| D | ARG199 |
| D | GLN212 |
| D | TRP263 |
| D | THR264 |
| D | PHE265 |
| site_id | HC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO D 409 |
| Chain | Residue |
| D | GLY183 |
| D | ASP227 |
| D | LEU229 |
| site_id | HC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO C 406 |
| Chain | Residue |
| A | GLU79 |
| C | VAL247 |
| C | ALA248 |
| C | GLU249 |
| site_id | HC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 413 |
| Chain | Residue |
| A | THR194 |
| A | SER197 |
| A | GLY211 |
| A | GLN212 |
| site_id | HC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 414 |
| Chain | Residue |
| A | GLU294 |
| A | TRP295 |
| A | ASN296 |
| A | LEU317 |
| site_id | HC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO A 415 |
| Chain | Residue |
| A | LYS175 |
| A | ALA241 |
| A | ALA242 |
| site_id | HC9 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO D 410 |
| Chain | Residue |
| C | ASP141 |
| C | ARG156 |
| C | MET158 |
| C | EDO398 |
| D | GLN162 |
| D | HIS165 |
| D | GLN244 |
| site_id | IC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO A 416 |
| Chain | Residue |
| A | LYS112 |
| A | LYS115 |
| A | HOH509 |
| site_id | IC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO D 411 |
| Chain | Residue |
| D | ASP297 |
| D | LEU365 |
| D | GLN366 |
| D | TRP367 |
| site_id | IC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO A 417 |
| Chain | Residue |
| A | ALA248 |
| A | ILE274 |
| C | LYS54 |
| site_id | IC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO C 407 |
| Chain | Residue |
| C | GLU207 |
| C | GLY252 |
| C | PHE267 |
| C | HOH550 |
| site_id | IC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO B 414 |
| Chain | Residue |
| B | SER197 |
| B | ARG199 |
| B | ALA208 |
| B | TRP263 |
| B | THR264 |
| B | PHE265 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: ACT_SITE => ECO:0000250 |
| Chain | Residue | Details |
| A | CYS164 | |
| B | CYS164 | |
| C | CYS164 | |
| D | CYS164 |
