3OSU
Crystal structure of the 3-oxoacyl-acyl carrier protein reductase, FabG, from Staphylococcus aureus
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004316 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0006631 | biological_process | fatty acid metabolic process |
| A | 0006633 | biological_process | fatty acid biosynthetic process |
| A | 0008610 | biological_process | lipid biosynthetic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0046394 | biological_process | carboxylic acid biosynthetic process |
| A | 0051287 | molecular_function | NAD binding |
| B | 0004316 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity |
| B | 0006629 | biological_process | lipid metabolic process |
| B | 0006631 | biological_process | fatty acid metabolic process |
| B | 0006633 | biological_process | fatty acid biosynthetic process |
| B | 0008610 | biological_process | lipid biosynthetic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0046394 | biological_process | carboxylic acid biosynthetic process |
| B | 0051287 | molecular_function | NAD binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PEG A 247 |
| Chain | Residue |
| A | THR93 |
| A | GLN151 |
| A | TYR154 |
| A | HOH319 |
| A | HOH348 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PEG A 248 |
| Chain | Residue |
| A | PRO149 |
| A | GLY150 |
| A | HOH345 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PEG A 249 |
| Chain | Residue |
| A | ALA51 |
| A | LYS52 |
| A | HOH362 |
| A | GLU48 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PEG A 250 |
| Chain | Residue |
| A | ASN89 |
| A | ALA90 |
| A | GLY91 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PEG A 251 |
| Chain | Residue |
| A | LYS74 |
| A | GLN127 |
| A | HOH350 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PEG A 252 |
| Chain | Residue |
| A | ARG170 |
| B | VAL146 |
| B | ASN148 |
| B | PHE186 |
| B | GLN206 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PEG A 253 |
| Chain | Residue |
| A | LYS52 |
| A | GLY53 |
| A | PEG254 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PEG A 254 |
| Chain | Residue |
| A | LYS50 |
| A | GLY53 |
| A | PEG253 |
| B | ASP197 |
| B | LEU204 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PEG A 255 |
| Chain | Residue |
| A | ASN62 |
| A | ALA64 |
| A | ASP67 |
| A | THR112 |
| site_id | BC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE MG A 256 |
| Chain | Residue |
| A | ARG14 |
| A | LYS41 |
| site_id | BC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG A 257 |
| Chain | Residue |
| A | ASN89 |
| A | LYS158 |
| A | HOH298 |
| site_id | BC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PO4 A 258 |
| Chain | Residue |
| A | GLN127 |
| A | ARG130 |
| A | GLN131 |
| B | ASP228 |
| B | LYS231 |
| site_id | BC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PO4 A 259 |
| Chain | Residue |
| A | LYS5 |
| A | ASP84 |
| A | GLY134 |
| A | ALA226 |
| A | HOH290 |
| A | HOH292 |
| site_id | BC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PEG B 247 |
| Chain | Residue |
| A | LYS166 |
| A | HOH271 |
| B | HOH310 |
| B | HOH338 |
| site_id | BC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PEG B 248 |
| Chain | Residue |
| A | VAL146 |
| A | ASN148 |
| A | GLN206 |
| A | MSE244 |
| B | ARG170 |
| site_id | BC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PEG B 249 |
| Chain | Residue |
| B | GLN127 |
| B | HOH320 |
| B | HOH331 |
| site_id | BC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PEG B 250 |
| Chain | Residue |
| B | ASN89 |
| B | ALA90 |
| B | GLY91 |
| site_id | BC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE PEG B 251 |
| Chain | Residue |
| B | GLN151 |
| B | TYR154 |
Functional Information from PROSITE/UniProt
| site_id | PS00061 |
| Number of Residues | 29 |
| Details | ADH_SHORT Short-chain dehydrogenases/reductases family signature. SvvgavgnpgQanYVATKAGViGLTkSAA |
| Chain | Residue | Details |
| A | SER141-ALA169 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU10001","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 22 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
