3OSL
Structure of bovine thrombin-activatable fibrinolysis inhibitor in complex with tick carboxypeptidase inhibitor
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004181 | molecular_function | metallocarboxypeptidase activity |
| A | 0005576 | cellular_component | extracellular region |
| A | 0006508 | biological_process | proteolysis |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0042730 | biological_process | fibrinolysis |
| B | 0004857 | molecular_function | enzyme inhibitor activity |
| B | 0005576 | cellular_component | extracellular region |
| B | 0007596 | biological_process | blood coagulation |
| B | 0008191 | molecular_function | metalloendopeptidase inhibitor activity |
| B | 0010951 | biological_process | negative regulation of endopeptidase activity |
| B | 0044002 | biological_process | acquisition of nutrients from host |
| C | 0004181 | molecular_function | metallocarboxypeptidase activity |
| C | 0005576 | cellular_component | extracellular region |
| C | 0006508 | biological_process | proteolysis |
| C | 0008270 | molecular_function | zinc ion binding |
| C | 0042730 | biological_process | fibrinolysis |
| D | 0004857 | molecular_function | enzyme inhibitor activity |
| D | 0005576 | cellular_component | extracellular region |
| D | 0007596 | biological_process | blood coagulation |
| D | 0008191 | molecular_function | metalloendopeptidase inhibitor activity |
| D | 0010951 | biological_process | negative regulation of endopeptidase activity |
| D | 0044002 | biological_process | acquisition of nutrients from host |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 999 |
| Chain | Residue |
| A | HIS181 |
| A | GLU184 |
| A | HIS310 |
| B | LEU74 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN C 999 |
| Chain | Residue |
| C | HIS181 |
| C | GLU184 |
| C | HIS310 |
| D | LEU74 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU01379","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P00730","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01379","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"18669641","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Site: {"description":"Cleavage; by thrombin","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
