3OSL

Structure of bovine thrombin-activatable fibrinolysis inhibitor in complex with tick carboxypeptidase inhibitor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004180	molecular_function	carboxypeptidase activity
A	0004181	molecular_function	metallocarboxypeptidase activity
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0006508	biological_process	proteolysis
A	0007596	biological_process	blood coagulation
A	0007599	biological_process	hemostasis
A	0008233	molecular_function	peptidase activity
A	0008237	molecular_function	metallopeptidase activity
A	0008270	molecular_function	zinc ion binding
A	0016787	molecular_function	hydrolase activity
A	0042730	biological_process	fibrinolysis
A	0046872	molecular_function	metal ion binding
B	0004857	molecular_function	enzyme inhibitor activity
B	0005576	cellular_component	extracellular region
B	0007596	biological_process	blood coagulation
B	0008191	molecular_function	metalloendopeptidase inhibitor activity
B	0010951	biological_process	negative regulation of endopeptidase activity
B	0030414	molecular_function	peptidase inhibitor activity
B	0035821	biological_process	modulation of process of another organism
B	0044002	biological_process	acquisition of nutrients from host
B	0090729	molecular_function	toxin activity
C	0004180	molecular_function	carboxypeptidase activity
C	0004181	molecular_function	metallocarboxypeptidase activity
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0006508	biological_process	proteolysis
C	0007596	biological_process	blood coagulation
C	0007599	biological_process	hemostasis
C	0008233	molecular_function	peptidase activity
C	0008237	molecular_function	metallopeptidase activity
C	0008270	molecular_function	zinc ion binding
C	0016787	molecular_function	hydrolase activity
C	0042730	biological_process	fibrinolysis
C	0046872	molecular_function	metal ion binding
D	0004857	molecular_function	enzyme inhibitor activity
D	0005576	cellular_component	extracellular region
D	0007596	biological_process	blood coagulation
D	0008191	molecular_function	metalloendopeptidase inhibitor activity
D	0010951	biological_process	negative regulation of endopeptidase activity
D	0030414	molecular_function	peptidase inhibitor activity
D	0035821	biological_process	modulation of process of another organism
D	0044002	biological_process	acquisition of nutrients from host
D	0090729	molecular_function	toxin activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 999

Chain	Residue
A	HIS181
A	GLU184
A	HIS310
B	LEU74

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 999

Chain	Residue
C	HIS181
C	GLU184
C	HIS310
D	LEU74

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU01379","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P00730","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01379","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"18669641","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Site: {"description":"Cleavage; by thrombin","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---